Hydroxyquinol 1,2-dioxygenase

Details

Name
Hydroxyquinol 1,2-dioxygenase
Synonyms
  • 1,2-HQD
  • 1.13.11.37
Gene Name
chqB
Organism
Nocardioides simplex
Amino acid sequence
>lcl|BSEQ0012217|Hydroxyquinol 1,2-dioxygenase
MSTPVSAEQQAREQDLVERVLRSFDATADPRLKQVMQALTRHLHAFLREVRLTEAEWETG
IGFLTDAGHVTNERRQEFILLSDVLGASMQTIAMNNEAHGDATEATVFGPFFVEGSPRIE
SGGDIAGGAAGEPCWVEGTVTDTDGNPVPDARIEVWEADDDGFYDVQYDDDRTAARAHLL
SGPDGGYAFWAITPTPYPIPHDGPVGRMLAATGRSPMRASHLHFMVTAPGRRTLVTHIFV
EGDELLDRDSVFGVKDSLVKSFERQPAGAPTPGGREIDGPWSRVRFDIVLAPA
Number of residues
293
Molecular Weight
31966.33
Theoretical pI
4.5
GO Classification
Functions
catechol 1,2-dioxygenase activity / ferric iron binding / hydroxyquinol 1,2-dioxygenase activity
Processes
beta-ketoadipate pathway / catechol-containing compound metabolic process
General Function
Hydroxyquinol 1,2-dioxygenase activity
Specific Function
Catalyzes the ortho-cleavage of the aromatic ring of hydroxyquinol.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0006199|882 bp
ATGAGCACGCCCGTCTCCGCCGAGCAGCAGGCCCGCGAGCAGGACCTGGTCGAGCGCGTG
CTGCGCTCCTTCGACGCCACCGCCGACCCGCGCCTGAAGCAGGTGATGCAGGCGCTGACC
CGGCACCTGCACGCCTTCCTGCGCGAGGTGCGGCTGACCGAGGCGGAGTGGGAGACCGGG
ATCGGCTTCCTGACCGACGCCGGTCACGTCACCAACGAGCGACGCCAGGAGTTCATCCTG
CTCTCCGACGTCCTCGGCGCGTCGATGCAGACGATCGCGATGAACAACGAGGCCCACGGC
GACGCCACCGAGGCCACCGTCTTCGGACCGTTCTTCGTCGAGGGGTCGCCGCGGATCGAG
TCCGGCGGTGACATCGCCGGTGGCGCGGCCGGCGAGCCGTGCTGGGTCGAGGGCACGGTC
ACCGACACCGACGGCAACCCCGTGCCCGATGCGCGGATCGAGGTGTGGGAGGCCGACGAC
GACGGCTTCTACGACGTCCAGTACGACGACGACCGCACCGCCGCGCGCGCCCACCTGCTC
AGCGGCCCGGACGGAGGCTATGCGTTCTGGGCGATCACGCCGACCCCCTACCCGATCCCC
CACGACGGGCCGGTCGGCCGGATGCTCGCCGCCACCGGCCGCTCCCCCATGCGCGCCTCG
CACCTGCACTTCATGGTCACCGCGCCCGGGCGGCGCACGTTGGTCACGCACATCTTCGTC
GAGGGCGACGAGCTGCTCGACCGCGACTCGGTGTTCGGCGTGAAGGACTCGCTTGTCAAG
AGCTTCGAGCGGCAGCCGGCCGGCGCGCCCACTCCCGGCGGCCGCGAGATCGACGGCCCC
TGGTCGCGGGTGCGCTTCGACATCGTCCTCGCTCCCGCCTGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ5PXQ6
UniProtKB Entry NameCHQB_NOCSI
GenBank Gene IDAY822041
General References
  1. Ferraroni M, Seifert J, Travkin VM, Thiel M, Kaschabek S, Scozzafava A, Golovleva L, Schlomann M, Briganti F: Crystal structure of the hydroxyquinol 1,2-dioxygenase from Nocardioides simplex 3E, a key enzyme involved in polychlorinated aromatics biodegradation. J Biol Chem. 2005 Jun 3;280(22):21144-54. Epub 2005 Mar 16. [Article]
  2. Travkin VM, Jadan AP, Briganti F, Scozzafava A, Golovleva LA: Characterization of an intradiol dioxygenase involved in the biodegradation of the chlorophenoxy herbicides 2,4-D and 2,4,5-T. FEBS Lett. 1997 Apr 21;407(1):69-72. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB03793Benzoic acidapproved, investigationalunknownDetails