Cytochrome c oxidase subunit 2

Details

Name
Cytochrome c oxidase subunit 2
Synonyms
  • 1.9.3.1
  • ctaC
  • Cytochrome c ba(3) subunit II
  • Cytochrome c oxidase polypeptide II
  • Cytochrome cba3 subunit 2
Gene Name
cbaB
Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Amino acid sequence
>lcl|BSEQ0019491|Cytochrome c oxidase subunit 2
MVDEHKAHKAILAYEKGWLAFSLAMLFVFIALIAYTLATHTAGVIPAGKLERVDPTTVRQ
EGPWADPAQAVVQTGPNQYTVYVLAFAFGYQPNPIEVPQGAEIVFKITSPDVIHGFHVEG
TNINVEVLPGEVSTVRYTFKRPGEYRIICNQYCGLGHQNMFGTIVVKE
Number of residues
168
Molecular Weight
18563.305
Theoretical pI
6.51
GO Classification
Functions
copper ion binding / cytochrome-c oxidase activity
Processes
electron transport chain
Components
integral component of membrane / plasma membrane / respiratory chain
General Function
Cytochrome-c oxidase activity
Specific Function
Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).
Pfam Domain Function
Transmembrane Regions
4-38
Cellular Location
Cell membrane
Gene sequence
>lcl|BSEQ0019492|Cytochrome c oxidase subunit 2 (cbaB)
ATGGTGGACGAGCACAAGGCCCACAAGGCGATCCTGGCCTACGAGAAGGGGTGGCTCGCC
TTCTCCTTGGCGATGCTCTTCGTCTTCATCGCCCTCATCGCCTACACCCTGGCCACCCAC
ACCGCCGGGGTCATTCCCGCCGGAAAGCTTGAGCGCGTGGACCCCACCACGGTAAGGCAG
GAAGGCCCCTGGGCCGACCCGGCCCAAGCGGTGGTGCAGACCGGCCCCAACCAGTACACG
GTCTACGTCCTGGCCTTCGCCTTCGGCTACCAGCCGAACCCCATTGAGGTGCCCCAAGGG
GCGGAGATCGTCTTCAAGATCACGAGCCCGGACGTGATCCACGGCTTTCACGTGGAGGGC
ACCAACATCAACGTGGAGGTGCTCCCGGGCGAGGTCTCCACCGTGCGCTACACCTTCAAA
AGGCCCGGGGAGTACCGCATCATCTGCAACCAGTACTGCGGCCTAGGCCACCAGAACATG
TTCGGCACGATCGTGGTGAAGGAGTGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ5SJ80
UniProtKB Entry NameCOX2_THET8
GenBank Protein ID5053134
GenBank Gene IDL09121
General References
  1. Keightley JA, Zimmermann BH, Mather MW, Springer P, Pastuszyn A, Lawrence DM, Fee JA: Molecular genetic and protein chemical characterization of the cytochrome ba3 from Thermus thermophilus HB8. J Biol Chem. 1995 Sep 1;270(35):20345-58. [Article]
  2. Soulimane T, Buse G, Bourenkov GP, Bartunik HD, Huber R, Than ME: Structure and mechanism of the aberrant ba(3)-cytochrome c oxidase from thermus thermophilus. EMBO J. 2000 Apr 17;19(8):1766-76. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB02451B-nonylglucosideexperimentalunknownDetails