RNA polymerase sigma factor SigA
Details
- Name
- RNA polymerase sigma factor SigA
- Synonyms
- RpoD
- Gene Name
- sigA
- Organism
- Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
- Amino acid sequence
>lcl|BSEQ0012357|RNA polymerase sigma factor SigA MKKSKRKNAQAQEAQETEVLVQEEAEELPEFPEGEPDPDLEDPDLTLEDDLLDLPEEGEG LDLEEEEEDLPIPKISTSDPVRQYLHEIGQVPLLTLEEEVELARKVEEGMEAIKKLSEIT GLDPDLIREVVRAKILGSARVRHIPGLKETLDPKTVEEIDQKLKSLPKEHKRYLHIAREG EAARQHLIEANLRLVVSIAKKYTGRGLSFLDLIQEGNQGLIRAVEKFEYKRRFKFSTYAT WWIRQAINRAIADQARTIRIPVHMVETINKLSRTARQLQQELGREPTYEEIAEAMGPGWD AKRVEETLKIAQEPVSLETPIGDEKDSFYGDFIPDEHLPSPVDAATQSLLSEELEKALSK LSEREAMVLKLRKGLIDGREHTLEEVGAFFGVTRERIRQIENKALRKLKYHESRTRKLRD FLD
- Number of residues
- 423
- Molecular Weight
- 48523.59
- Theoretical pI
- 4.77
- GO Classification
- FunctionsDNA binding / metal ion binding / sigma factor activity / transcription factor activity, sequence-specific DNA bindingProcessestranscription initiation from bacterial-type RNA polymerase promoterComponentscytoplasm
- General Function
- Transcription factor activity, sequence-specific dna binding
- Specific Function
- Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0012358|RNA polymerase sigma factor SigA (sigA) TTGAAGAAGAGCAAGCGCAAGAACGCCCAGGCCCAGGAGGCCCAGGAGACCGAGGTCCTG GTCCAGGAGGAGGCGGAGGAACTCCCCGAGTTCCCCGAGGGGGAGCCCGACCCCGACCTC GAGGACCCGGACCTCACCCTGGAGGACGACCTCCTGGACCTGCCCGAGGAGGGCGAGGGG CTGGACCTGGAGGAGGAGGAAGAAGACCTCCCCATCCCCAAGATCTCCACCTCCGACCCC GTGCGCCAGTACCTGCACGAGATCGGCCAGGTCCCCCTCCTCACCCTGGAGGAGGAGGTG GAGCTCGCCCGGAAGGTGGAGGAGGGGATGGAGGCCATCAAGAAGCTCTCCGAGATCACC GGCCTTGACCCCGACCTCATCCGGGAGGTGGTCCGGGCCAAGATTCTGGGCTCGGCCCGG GTGCGGCACATCCCCGGCCTCAAGGAGACCCTGGACCCCAAGACCGTGGAGGAGATTGAC CAGAAGCTCAAAAGCCTCCCCAAGGAGCACAAGCGCTACCTCCACATCGCCCGGGAAGGG GAGGCGGCCCGGCAGCACCTCATTGAGGCCAACCTCCGGCTCGTGGTCTCCATCGCCAAG AAGTACACGGGGCGGGGCCTCTCCTTCCTGGACCTCATCCAGGAGGGAAACCAGGGCCTG ATCCGGGCGGTGGAGAAGTTTGAGTACAAGCGGCGCTTCAAGTTCTCCACCTACGCCACC TGGTGGATCCGGCAGGCCATCAACCGGGCCATCGCCGACCAGGCCCGCACCATCCGCATC CCGGTCCACATGGTGGAGACCATCAACAAGCTCTCCCGCACCGCAAGGCAGCTGCAGCAG GAGCTCGGCCGGGAACCCACCTACGAGGAGATCGCCGAGGCCATGGGGCCGGGCTGGGAC GCCAAGCGGGTGGAGGAAACCCTCAAGATCGCCCAGGAGCCCGTCTCCCTGGAGACCCCC ATCGGCGACGAGAAGGACAGCTTCTACGGGGACTTCATCCCCGACGAGCACCTCCCCTCC CCGGTGGACGCCGCCACCCAGAGCCTCCTCTCCGAGGAGCTGGAGAAGGCCCTGTCCAAG CTCTCCGAGCGCGAGGCCATGGTCCTGAAGCTCCGGAAAGGGCTCATTGACGGGCGGGAG CACACCCTGGAGGAGGTGGGGGCCTTCTTCGGCGTCACCCGGGAAAGGATCCGGCAGATT GAGAACAAGGCCCTCCGCAAGCTCAAGTACCACGAGTCCCGCACGCGGAAGCTCAGGGAC TTCCTGGACTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q5SKW1 UniProtKB Entry Name Q5SKW1_THET8 GenBank Gene ID AP008226 - General References
- Artsimovitch I, Vassylyeva MN, Svetlov D, Svetlov V, Perederina A, Igarashi N, Matsugaki N, Wakatsuki S, Tahirov TH, Vassylyev DG: Allosteric modulation of the RNA polymerase catalytic reaction is an essential component of transcription control by rifamycins. Cell. 2005 Aug 12;122(3):351-63. [Article]
- Tuske S, Sarafianos SG, Wang X, Hudson B, Sineva E, Mukhopadhyay J, Birktoft JJ, Leroy O, Ismail S, Clark AD Jr, Dharia C, Napoli A, Laptenko O, Lee J, Borukhov S, Ebright RH, Arnold E: Inhibition of bacterial RNA polymerase by streptolydigin: stabilization of a straight-bridge-helix active-center conformation. Cell. 2005 Aug 26;122(4):541-52. [Article]
- Temiakov D, Zenkin N, Vassylyeva MN, Perederina A, Tahirov TH, Kashkina E, Savkina M, Zorov S, Nikiforov V, Igarashi N, Matsugaki N, Wakatsuki S, Severinov K, Vassylyev DG: Structural basis of transcription inhibition by antibiotic streptolydigin. Mol Cell. 2005 Sep 2;19(5):655-66. [Article]
- Vassylyev DG, Svetlov V, Vassylyeva MN, Perederina A, Igarashi N, Matsugaki N, Wakatsuki S, Artsimovitch I: Structural basis for transcription inhibition by tagetitoxin. Nat Struct Mol Biol. 2005 Dec;12(12):1086-93. Epub 2005 Nov 6. [Article]
- Mukhopadhyay J, Das K, Ismail S, Koppstein D, Jang M, Hudson B, Sarafianos S, Tuske S, Patel J, Jansen R, Irschik H, Arnold E, Ebright RH: The RNA polymerase "switch region" is a target for inhibitors. Cell. 2008 Oct 17;135(2):295-307. doi: 10.1016/j.cell.2008.09.033. [Article]
- Belogurov GA, Vassylyeva MN, Sevostyanova A, Appleman JR, Xiang AX, Lira R, Webber SE, Klyuyev S, Nudler E, Artsimovitch I, Vassylyev DG: Transcription inactivation through local refolding of the RNA polymerase structure. Nature. 2009 Jan 15;457(7227):332-5. doi: 10.1038/nature07510. Epub 2008 Oct 22. [Article]
- Zhang Y, Feng Y, Chatterjee S, Tuske S, Ho MX, Arnold E, Ebright RH: Structural basis of transcription initiation. Science. 2012 Nov 23;338(6110):1076-80. doi: 10.1126/science.1227786. Epub 2012 Oct 18. [Article]
- Zhang Y, Degen D, Ho MX, Sineva E, Ebright KY, Ebright YW, Mekler V, Vahedian-Movahed H, Feng Y, Yin R, Tuske S, Irschik H, Jansen R, Maffioli S, Donadio S, Arnold E, Ebright RH: GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides. Elife. 2014 Apr 22;3:e02450. doi: 10.7554/eLife.02450. [Article]
- Tagami S, Sekine S, Minakhin L, Esyunina D, Akasaka R, Shirouzu M, Kulbachinskiy A, Severinov K, Yokoyama S: Structural basis for promoter specificity switching of RNA polymerase by a phage factor. Genes Dev. 2014 Mar 1;28(5):521-31. doi: 10.1101/gad.233916.113. [Article]
- Basu RS, Warner BA, Molodtsov V, Pupov D, Esyunina D, Fernandez-Tornero C, Kulbachinskiy A, Murakami KS: Structural basis of transcription initiation by bacterial RNA polymerase holoenzyme. J Biol Chem. 2014 Aug 29;289(35):24549-59. doi: 10.1074/jbc.M114.584037. Epub 2014 Jun 27. [Article]