Adhesion G-protein coupled receptor F1

Details

Name

Adhesion G-protein coupled receptor F1

Synonyms

• G-protein coupled receptor 110
• G-protein coupled receptor KPG_012
• G-protein coupled receptor PGR19
• GPR110
• PGR19

Gene Name

ADGRF1

Organism

Humans

Amino acid sequence

>lcl|BSEQ0037203|Adhesion G-protein coupled receptor F1
MKVGVLWLISFFTFTDGHGGFLGKNDGIKTKKELIVNKKKHLGPVEEYQLLLQVTYRDSK
EKRDLRNFLKLLKPPLLWSHGLIRIIRAKATTDCNSLNGVLQCTCEDSYTWFPPSCLDPQ
NCYLHTAGALPSCECHLNNLSQSVNFCERTKIWGTFKINERFTNDLLNSSSAIYSKYANG
IEIQLKKAYERIQGFESVQVTQFRNGSIVAGYEVVGSSSASELLSAIEHVAEKAKTALHK
LFPLEDGSFRVFGKAQCNDIVFGFGSKDDEYTLPCSSGYRGNITAKCESSGWQVIRETCV
LSLLEELNKNFSMIVGNATEAAVSSFVQNLSVIIRQNPSTTVGNLASVVSILSNISSLSL
ASHFRVSNSTMEDVISIADNILNSASVTNWTVLLREEKYASSRLLETLENISTLVPPTAL
PLNFSRKFIDWKGIPVNKSQLKRGYSYQIKMCPQNTSIPIRGRVLIGSDQFQRSLPETII
SMASLTLGNILPVSKNGNAQVNGPVISTVIQNYSINEVFLFFSKIESNLSQPHCVFWDFS
HLQWNDAGCHLVNETQDIVTCQCTHLTSFSILMSPFVPSTIFPVVKWITYVGLGISIGSL
ILCLIIEALFWKQIKKSQTSHTRRICMVNIALSLLIADVWFIVGATVDTTVNPSGVCTAA
VFFTHFFYLSLFFWMLMLGILLAYRIILVFHHMAQHLMMAVGFCLGYGCPLIISVITIAV
TQPSNTYKRKDVCWLNWSNGSKPLLAFVVPALAIVAVNFVVVLLVLTKLWRPTVGERLSR
DDKATIIRVGKSLLILTPLLGLTWGFGIGTIVDSQNLAWHVIFALLNAFQGFFILCFGIL
LDSKLRQLLFNKLSALSSWKQTEKQNSSDLSAKPKFSKPFNPLQNKGHYAFSHTGDSSDN
IMLTQFVSNE

Number of residues

910

Molecular Weight

101363.665

Theoretical pI

8.74

GO Classification

Functions

G-protein coupled receptor activity

Processes

cell surface receptor signaling pathway / G-protein coupled receptor signaling pathway

Components

extracellular region / integral component of membrane / plasma membrane

General Function

G-protein coupled receptor activity

Specific Function

Orphan receptor.

Pfam Domain Function

• 7tm_2 (PF00002)
• SEA (PF01390)
• GPS (PF01825)

Transmembrane Regions

591-611 625-645 661-681 700-720 745-765 792-812 821-841

Cellular Location

Cell membrane

Gene sequence

>lcl|BSEQ0011725|Adhesion G-protein coupled receptor F1 (ADGRF1)
ATGAAAGTTGGAGTGCTGTGGCTCATTTCTTTCTTCACCTTCACTGACGGCCACGGTGGC
TTCCTGGGGAAAAATGATGGCATCAAAACAAAAAAAGAACTCATTGTGAATAAGAAAAAA
CATCTAGGCCCAGTCGAAGAATATCAGCTGCTGCTTCAGGTGACCTATAGAGATTCCAAG
GAGAAAAGAGATTTGAGAAATTTTCTGAAGCTCTTGAAGCCTCCATTATTATGGTCACAT
GGGCTAATTAGAATTATCAGAGCAAAGGCTACCACAGACTGCAACAGCCTGAATGGAGTC
CTGCAGTGTACCTGTGAAGACAGCTACACCTGGTTTCCTCCCTCATGCCTTGATCCCCAG
AACTGCTACCTTCACACGGCTGGAGCACTCCCAAGCTGTGAATGTCATCTCAACAACCTC
AGCCAGAGTGTCAATTTCTGTGAGAGAACAAAGATTTGGGGCACTTTCAAAATTAATGAA
AGGTTTACAAATGACCTTTTGAATTCATCTTCTGCTATATACTCCAAATATGCAAATGGA
ATTGAAATTCAACTTAAAAAAGCATATGAAAGAATTCAAGGTTTTGAGTCGGTTCAGGTC
ACCCAATTTCGAATGTCACTCTTGTCGCCCAAGTTGGAGTGCAATGGCACAATCTAG

Chromosome Location

6

Locus

6p12.3

External Identifiers

Resource	Link
UniProtKB ID	Q5T601
UniProtKB Entry Name	AGRF1_HUMAN
GenBank Gene ID	AB045123
GenAtlas ID	GPR110
HGNC ID	HGNC:18990

General References

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4. Fredriksson R, Lagerstrom MC, Hoglund PJ, Schioth HB: Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions. FEBS Lett. 2002 Nov 20;531(3):407-14. [Article]
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Drug Relations

Drug Relations

DrugBank ID	Name	Drug group	Pharmacological action?	Actions	Details