3-dehydroquinate dehydratase

Details

Name
3-dehydroquinate dehydratase
Synonyms
  • 3-dehydroquinase
  • 4.2.1.10
  • DHQ1
  • Type I dehydroquinase
  • Type I DHQase
Gene Name
aroD
Organism
Staphylococcus aureus (strain MRSA252)
Amino acid sequence
>lcl|BSEQ0011205|3-dehydroquinate dehydratase
MTHVEVVATITPQLYIEETLIQKINHRIDAIDVLELRIDQFENVTVDQVAEMITKLKVMQ
DSFKLLVTYRTKLQGGYGQFTNDSYLNLISDLANINGIDMIDIEWQADIDIEKHQRIITH
LQQYNKEVIISHHNFESTPPLDELQFIFFKMQKFNPEYVKLAVMPHNKNDVLNLLQAMST
FSDTMDCKVVGISMSKLGLISRTAQGVFGGALTYGCIGEPQAPGQIDVTDLKAQVTLY
Number of residues
238
Molecular Weight
27052.965
Theoretical pI
4.8
GO Classification
Functions
3-dehydroquinate dehydratase activity
Processes
aromatic amino acid family biosynthetic process / chorismate biosynthetic process
General Function
3-dehydroquinate dehydratase activity
Specific Function
Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0011206|3-dehydroquinate dehydratase (aroD)
ATGACACATGTGGAAGTAGTAGCGACTATCACGCCACAATTATATATCGAAGAAACTTTA
ATTCAAAAAATTAATCATCGTATTGATGCAATAGACGTATTAGAATTACGAATTGATCAA
TTTGAAAATGTCACAGTTGATCAAGTGGCAGAAATGATTACAAAGCTGAAGGTTATGCAA
GATTCATTCAAATTATTGGTTACGTATCGTACAAAGTTACAAGGTGGCTATGGGCAATTT
ACAAATGACTCGTATCTTAATTTAATATCAGACTTAGCAAATATCAATGGCATAGATATG
ATTGATATAGAATGGCAAGCAGATATTGACATTGAAAAACATCAACGAATCATTACACAT
TTGCAACAGTATAATAAAGAGGTGATTATATCACATCATAATTTCGAAAGTACGCCTCCA
TTAGATGAATTGCAATTTATATTTTTTAAAATGCAAAAATTCAACCCAGAATACGTTAAA
TTAGCAGTAATGCCACATAATAAAAATGATGTGCTAAATTTATTGCAGGCAATGTCTACA
TTTTCAGATACTATGGACTGCAAAGTTGTTGGTATTTCAATGTCTAAACTTGGACTAATA
AGTAGAACGGCTCAAGGCGTTTTTGGTGGTGCGTTGACTTATGGTTGTATCGGAGAACCA
CAAGCTCCAGGACAGATTGATGTTACTGATTTAAAAGCACAAGTGACTTTATACTAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ6GII7
UniProtKB Entry NameAROD_STAAR
GenBank Protein ID49241190
GenBank Gene IDBX571856
General References
  1. Holden MT, Feil EJ, Lindsay JA, Peacock SJ, Day NP, Enright MC, Foster TJ, Moore CE, Hurst L, Atkin R, Barron A, Bason N, Bentley SD, Chillingworth C, Chillingworth T, Churcher C, Clark L, Corton C, Cronin A, Doggett J, Dowd L, Feltwell T, Hance Z, Harris B, Hauser H, Holroyd S, Jagels K, James KD, Lennard N, Line A, Mayes R, Moule S, Mungall K, Ormond D, Quail MA, Rabbinowitsch E, Rutherford K, Sanders M, Sharp S, Simmonds M, Stevens K, Whitehead S, Barrell BG, Spratt BG, Parkhill J: Complete genomes of two clinical Staphylococcus aureus strains: evidence for the rapid evolution of virulence and drug resistance. Proc Natl Acad Sci U S A. 2004 Jun 29;101(26):9786-91. Epub 2004 Jun 22. [Article]
  2. Nichols CE, Lockyer M, Hawkins AR, Stammers DK: Crystal structures of Staphylococcus aureus type I dehydroquinase from enzyme turnover experiments. Proteins. 2004 Aug 15;56(3):625-8. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB043473-DehydroshikimateexperimentalunknownDetails