3-dehydroquinate dehydratase
Details
- Name
- 3-dehydroquinate dehydratase
- Synonyms
- 3-dehydroquinase
- 4.2.1.10
- DHQ1
- Type I dehydroquinase
- Type I DHQase
- Gene Name
- aroD
- Organism
- Staphylococcus aureus (strain MRSA252)
- Amino acid sequence
>lcl|BSEQ0011205|3-dehydroquinate dehydratase MTHVEVVATITPQLYIEETLIQKINHRIDAIDVLELRIDQFENVTVDQVAEMITKLKVMQ DSFKLLVTYRTKLQGGYGQFTNDSYLNLISDLANINGIDMIDIEWQADIDIEKHQRIITH LQQYNKEVIISHHNFESTPPLDELQFIFFKMQKFNPEYVKLAVMPHNKNDVLNLLQAMST FSDTMDCKVVGISMSKLGLISRTAQGVFGGALTYGCIGEPQAPGQIDVTDLKAQVTLY
- Number of residues
- 238
- Molecular Weight
- 27052.965
- Theoretical pI
- 4.8
- GO Classification
- Functions3-dehydroquinate dehydratase activityProcessesaromatic amino acid family biosynthetic process / chorismate biosynthetic process
- General Function
- 3-dehydroquinate dehydratase activity
- Specific Function
- Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.
- Pfam Domain Function
- DHquinase_I (PF01487)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0011206|3-dehydroquinate dehydratase (aroD) ATGACACATGTGGAAGTAGTAGCGACTATCACGCCACAATTATATATCGAAGAAACTTTA ATTCAAAAAATTAATCATCGTATTGATGCAATAGACGTATTAGAATTACGAATTGATCAA TTTGAAAATGTCACAGTTGATCAAGTGGCAGAAATGATTACAAAGCTGAAGGTTATGCAA GATTCATTCAAATTATTGGTTACGTATCGTACAAAGTTACAAGGTGGCTATGGGCAATTT ACAAATGACTCGTATCTTAATTTAATATCAGACTTAGCAAATATCAATGGCATAGATATG ATTGATATAGAATGGCAAGCAGATATTGACATTGAAAAACATCAACGAATCATTACACAT TTGCAACAGTATAATAAAGAGGTGATTATATCACATCATAATTTCGAAAGTACGCCTCCA TTAGATGAATTGCAATTTATATTTTTTAAAATGCAAAAATTCAACCCAGAATACGTTAAA TTAGCAGTAATGCCACATAATAAAAATGATGTGCTAAATTTATTGCAGGCAATGTCTACA TTTTCAGATACTATGGACTGCAAAGTTGTTGGTATTTCAATGTCTAAACTTGGACTAATA AGTAGAACGGCTCAAGGCGTTTTTGGTGGTGCGTTGACTTATGGTTGTATCGGAGAACCA CAAGCTCCAGGACAGATTGATGTTACTGATTTAAAAGCACAAGTGACTTTATACTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q6GII7 UniProtKB Entry Name AROD_STAAR GenBank Protein ID 49241190 GenBank Gene ID BX571856 - General References
- Holden MT, Feil EJ, Lindsay JA, Peacock SJ, Day NP, Enright MC, Foster TJ, Moore CE, Hurst L, Atkin R, Barron A, Bason N, Bentley SD, Chillingworth C, Chillingworth T, Churcher C, Clark L, Corton C, Cronin A, Doggett J, Dowd L, Feltwell T, Hance Z, Harris B, Hauser H, Holroyd S, Jagels K, James KD, Lennard N, Line A, Mayes R, Moule S, Mungall K, Ormond D, Quail MA, Rabbinowitsch E, Rutherford K, Sanders M, Sharp S, Simmonds M, Stevens K, Whitehead S, Barrell BG, Spratt BG, Parkhill J: Complete genomes of two clinical Staphylococcus aureus strains: evidence for the rapid evolution of virulence and drug resistance. Proc Natl Acad Sci U S A. 2004 Jun 29;101(26):9786-91. Epub 2004 Jun 22. [Article]
- Nichols CE, Lockyer M, Hawkins AR, Stammers DK: Crystal structures of Staphylococcus aureus type I dehydroquinase from enzyme turnover experiments. Proteins. 2004 Aug 15;56(3):625-8. [Article]