Sulfotransferase 1C3

Details

Name
Sulfotransferase 1C3
Synonyms
  • 2.8.2.2
  • ST1C3
Gene Name
SULT1C3
Organism
Humans
Amino acid sequence
>lcl|BSEQ0052140|Sulfotransferase 1C3
MAKIEKNAPTMEKKPELFNIMEVDGVPTLILSKEWWEKVCNFQAKPDDLILATYPKSGTT
WMHEILDMILNDGDVEKCKRAQTLDRHAFLELKFPHKEKPDLEFVLEMSSPQLIKTHLPS
HLIPPSIWKENCKIVYVARNPKDCLVSYYHFHRMASFMPDPQNLEEFYEKFMSGKVVGGS
WFDHVKGWWAAKDMHRILYLFYEDIKKDPKREIEKILKFLEKDISEEILNKIIYHTSFDV
MKQNPMTNYTTLPTSIMDHSISPFMRKGMPGDWKNYFTVAQNEEFDKDYQKKMAGSTLTF
RTEI
Number of residues
304
Molecular Weight
35888.345
Theoretical pI
Not Available
GO Classification
Functions
alcohol sulfotransferase activity / aryl sulfotransferase activity
Processes
sulfur compound metabolic process
Components
cytoplasm
General Function
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor and has low sulphotransferase activity towards various substrates with alcohol groups (in vitro). May catalyze the sulfate conjugation of xenobiotic compounds and endogenous substrates.
Specific Function
Alcohol sulfotransferase activity
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0052141|Sulfotransferase 1C3 (SULT1C3)
ATGGCGAAGATTGAGAAAAACGCTCCCACGATGGAAAAAAAGCCAGAACTGTTTAACATC
ATGGAAGTAGATGGAGTCCCTACGTTGATATTATCAAAAGAATGGTGGGAAAAAGTATGT
AATTTCCAAGCCAAGCCTGATGATCTTATTCTGGCAACTTACCCAAAGTCAGGTACAACA
TGGATGCATGAAATTTTAGACATGATTCTAAATGATGGTGATGTGGAGAAATGCAAAAGA
GCCCAGACTCTAGATAGACACGCTTTCCTTGAACTGAAATTTCCCCATAAAGAAAAACCA
GATTTGGAGTTCGTTCTTGAAATGTCCTCACCACAACTGATAAAAACACATCTCCCTTCA
CATCTGATTCCACCATCTATCTGGAAAGAAAACTGCAAGATTGTCTATGTGGCCAGAAAT
CCCAAGGATTGCCTGGTGTCCTACTACCACTTTCACAGGATGGCTTCCTTTATGCCTGAT
CCTCAGAACTTAGAGGAATTTTATGAGAAATTCATGTCCGGAAAAGTTGTTGGCGGGTCC
TGGTTTGACCATGTGAAAGGATGGTGGGCTGCAAAAGACATGCACCGGATCCTCTACCTC
TTCTACGAGGATATTAAAAAAGACCCAAAGCGGGAAATTGAGAAGATACTGAAGTTCCTG
GAAAAAGACATATCAGAGGAAATTCTGAATAAAATCATCTATCACACCTCCTTTGATGTA
ATGAAGCAAAACCCAATGACCAACTATACCACTTTGCCCACCAGCATTATGGACCACTCC
ATCTCCCCTTTTATGAGGAAAGGGATGCCTGGAGACTGGAAGAACTATTTTACTGTGGCC
CAAAATGAAGAATTTGACAAGGACTACCAGAAGAAGATGGCAGGAAGCACCCTAACCTTC
CGCACAGAGATCTGA
Chromosome Location
2
Locus
2q12.3
External Identifiers
ResourceLink
UniProtKB IDQ6IMI6
UniProtKB Entry NameST1C3_HUMAN
HGNC IDHGNC:33543
General References
  1. Hillier LW, Graves TA, Fulton RS, Fulton LA, Pepin KH, Minx P, Wagner-McPherson C, Layman D, Wylie K, Sekhon M, Becker MC, Fewell GA, Delehaunty KD, Miner TL, Nash WE, Kremitzki C, Oddy L, Du H, Sun H, Bradshaw-Cordum H, Ali J, Carter J, Cordes M, Harris A, Isak A, van Brunt A, Nguyen C, Du F, Courtney L, Kalicki J, Ozersky P, Abbott S, Armstrong J, Belter EA, Caruso L, Cedroni M, Cotton M, Davidson T, Desai A, Elliott G, Erb T, Fronick C, Gaige T, Haakenson W, Haglund K, Holmes A, Harkins R, Kim K, Kruchowski SS, Strong CM, Grewal N, Goyea E, Hou S, Levy A, Martinka S, Mead K, McLellan MD, Meyer R, Randall-Maher J, Tomlinson C, Dauphin-Kohlberg S, Kozlowicz-Reilly A, Shah N, Swearengen-Shahid S, Snider J, Strong JT, Thompson J, Yoakum M, Leonard S, Pearman C, Trani L, Radionenko M, Waligorski JE, Wang C, Rock SM, Tin-Wollam AM, Maupin R, Latreille P, Wendl MC, Yang SP, Pohl C, Wallis JW, Spieth J, Bieri TA, Berkowicz N, Nelson JO, Osborne J, Ding L, Meyer R, Sabo A, Shotland Y, Sinha P, Wohldmann PE, Cook LL, Hickenbotham MT, Eldred J, Williams D, Jones TA, She X, Ciccarelli FD, Izaurralde E, Taylor J, Schmutz J, Myers RM, Cox DR, Huang X, McPherson JD, Mardis ER, Clifton SW, Warren WC, Chinwalla AT, Eddy SR, Marra MA, Ovcharenko I, Furey TS, Miller W, Eichler EE, Bork P, Suyama M, Torrents D, Waterston RH, Wilson RK: Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Nature. 2005 Apr 7;434(7034):724-31. [Article]
  2. Freimuth RR, Wiepert M, Chute CG, Wieben ED, Weinshilboum RM: Human cytosolic sulfotransferase database mining: identification of seven novel genes and pseudogenes. Pharmacogenomics J. 2004;4(1):54-65. doi: 10.1038/sj.tpj.6500223. [Article]
  3. Meinl W, Donath C, Schneider H, Sommer Y, Glatt H: SULT1C3, an orphan sequence of the human genome, encodes an enzyme activating various promutagens. Food Chem Toxicol. 2008 Apr;46(4):1249-56. doi: 10.1016/j.fct.2007.08.040. Epub 2007 Sep 6. [Article]
  4. Duniec-Dmuchowski Z, Rondini EA, Tibbs ZE, Falany CN, Runge-Morris M, Kocarek TA: Expression of the orphan cytosolic sulfotransferase SULT1C3 in human intestine: characterization of the transcript variant and implications for function. Drug Metab Dispos. 2014 Mar;42(3):352-60. doi: 10.1124/dmd.113.055665. Epub 2013 Dec 11. [Article]
  5. Allali-Hassani A, Pan PW, Dombrovski L, Najmanovich R, Tempel W, Dong A, Loppnau P, Martin F, Thornton J, Edwards AM, Bochkarev A, Plotnikov AN, Vedadi M, Arrowsmith CH: Structural and chemical profiling of the human cytosolic sulfotransferases. PLoS Biol. 2007 May;5(5):e97. doi: 10.1371/journal.pbio.0050097. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00871TerbutalineapprovedunknownsubstrateDetails
DB00960Pindololapproved, investigationalunknownsubstrateDetails
DB00968MethyldopaapprovednosubstrateDetails
DB12471Ibrexafungerpapproved, investigationalunknownsubstrateDetails
DB00867Ritodrineapproved, investigationalnosubstrateDetails
DB12243Edaravoneapproved, investigationalnosubstrateDetails