Sulfotransferase 1C3
Details
- Name
- Sulfotransferase 1C3
- Synonyms
- 2.8.2.2
- ST1C3
- Gene Name
- SULT1C3
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0052140|Sulfotransferase 1C3 MAKIEKNAPTMEKKPELFNIMEVDGVPTLILSKEWWEKVCNFQAKPDDLILATYPKSGTT WMHEILDMILNDGDVEKCKRAQTLDRHAFLELKFPHKEKPDLEFVLEMSSPQLIKTHLPS HLIPPSIWKENCKIVYVARNPKDCLVSYYHFHRMASFMPDPQNLEEFYEKFMSGKVVGGS WFDHVKGWWAAKDMHRILYLFYEDIKKDPKREIEKILKFLEKDISEEILNKIIYHTSFDV MKQNPMTNYTTLPTSIMDHSISPFMRKGMPGDWKNYFTVAQNEEFDKDYQKKMAGSTLTF RTEI
- Number of residues
- 304
- Molecular Weight
- 35888.345
- Theoretical pI
- Not Available
- GO Classification
- Functionsalcohol sulfotransferase activity / aryl sulfotransferase activityProcessessulfur compound metabolic processComponentscytoplasm
- General Function
- Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor and has low sulphotransferase activity towards various substrates with alcohol groups (in vitro). May catalyze the sulfate conjugation of xenobiotic compounds and endogenous substrates.
- Specific Function
- Alcohol sulfotransferase activity
- Pfam Domain Function
- Sulfotransfer_1 (PF00685)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0052141|Sulfotransferase 1C3 (SULT1C3) ATGGCGAAGATTGAGAAAAACGCTCCCACGATGGAAAAAAAGCCAGAACTGTTTAACATC ATGGAAGTAGATGGAGTCCCTACGTTGATATTATCAAAAGAATGGTGGGAAAAAGTATGT AATTTCCAAGCCAAGCCTGATGATCTTATTCTGGCAACTTACCCAAAGTCAGGTACAACA TGGATGCATGAAATTTTAGACATGATTCTAAATGATGGTGATGTGGAGAAATGCAAAAGA GCCCAGACTCTAGATAGACACGCTTTCCTTGAACTGAAATTTCCCCATAAAGAAAAACCA GATTTGGAGTTCGTTCTTGAAATGTCCTCACCACAACTGATAAAAACACATCTCCCTTCA CATCTGATTCCACCATCTATCTGGAAAGAAAACTGCAAGATTGTCTATGTGGCCAGAAAT CCCAAGGATTGCCTGGTGTCCTACTACCACTTTCACAGGATGGCTTCCTTTATGCCTGAT CCTCAGAACTTAGAGGAATTTTATGAGAAATTCATGTCCGGAAAAGTTGTTGGCGGGTCC TGGTTTGACCATGTGAAAGGATGGTGGGCTGCAAAAGACATGCACCGGATCCTCTACCTC TTCTACGAGGATATTAAAAAAGACCCAAAGCGGGAAATTGAGAAGATACTGAAGTTCCTG GAAAAAGACATATCAGAGGAAATTCTGAATAAAATCATCTATCACACCTCCTTTGATGTA ATGAAGCAAAACCCAATGACCAACTATACCACTTTGCCCACCAGCATTATGGACCACTCC ATCTCCCCTTTTATGAGGAAAGGGATGCCTGGAGACTGGAAGAACTATTTTACTGTGGCC CAAAATGAAGAATTTGACAAGGACTACCAGAAGAAGATGGCAGGAAGCACCCTAACCTTC CGCACAGAGATCTGA
- Chromosome Location
- 2
- Locus
- 2q12.3
- External Identifiers
Resource Link UniProtKB ID Q6IMI6 UniProtKB Entry Name ST1C3_HUMAN HGNC ID HGNC:33543 - General References
- Hillier LW, Graves TA, Fulton RS, Fulton LA, Pepin KH, Minx P, Wagner-McPherson C, Layman D, Wylie K, Sekhon M, Becker MC, Fewell GA, Delehaunty KD, Miner TL, Nash WE, Kremitzki C, Oddy L, Du H, Sun H, Bradshaw-Cordum H, Ali J, Carter J, Cordes M, Harris A, Isak A, van Brunt A, Nguyen C, Du F, Courtney L, Kalicki J, Ozersky P, Abbott S, Armstrong J, Belter EA, Caruso L, Cedroni M, Cotton M, Davidson T, Desai A, Elliott G, Erb T, Fronick C, Gaige T, Haakenson W, Haglund K, Holmes A, Harkins R, Kim K, Kruchowski SS, Strong CM, Grewal N, Goyea E, Hou S, Levy A, Martinka S, Mead K, McLellan MD, Meyer R, Randall-Maher J, Tomlinson C, Dauphin-Kohlberg S, Kozlowicz-Reilly A, Shah N, Swearengen-Shahid S, Snider J, Strong JT, Thompson J, Yoakum M, Leonard S, Pearman C, Trani L, Radionenko M, Waligorski JE, Wang C, Rock SM, Tin-Wollam AM, Maupin R, Latreille P, Wendl MC, Yang SP, Pohl C, Wallis JW, Spieth J, Bieri TA, Berkowicz N, Nelson JO, Osborne J, Ding L, Meyer R, Sabo A, Shotland Y, Sinha P, Wohldmann PE, Cook LL, Hickenbotham MT, Eldred J, Williams D, Jones TA, She X, Ciccarelli FD, Izaurralde E, Taylor J, Schmutz J, Myers RM, Cox DR, Huang X, McPherson JD, Mardis ER, Clifton SW, Warren WC, Chinwalla AT, Eddy SR, Marra MA, Ovcharenko I, Furey TS, Miller W, Eichler EE, Bork P, Suyama M, Torrents D, Waterston RH, Wilson RK: Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Nature. 2005 Apr 7;434(7034):724-31. [Article]
- Freimuth RR, Wiepert M, Chute CG, Wieben ED, Weinshilboum RM: Human cytosolic sulfotransferase database mining: identification of seven novel genes and pseudogenes. Pharmacogenomics J. 2004;4(1):54-65. doi: 10.1038/sj.tpj.6500223. [Article]
- Meinl W, Donath C, Schneider H, Sommer Y, Glatt H: SULT1C3, an orphan sequence of the human genome, encodes an enzyme activating various promutagens. Food Chem Toxicol. 2008 Apr;46(4):1249-56. doi: 10.1016/j.fct.2007.08.040. Epub 2007 Sep 6. [Article]
- Duniec-Dmuchowski Z, Rondini EA, Tibbs ZE, Falany CN, Runge-Morris M, Kocarek TA: Expression of the orphan cytosolic sulfotransferase SULT1C3 in human intestine: characterization of the transcript variant and implications for function. Drug Metab Dispos. 2014 Mar;42(3):352-60. doi: 10.1124/dmd.113.055665. Epub 2013 Dec 11. [Article]
- Allali-Hassani A, Pan PW, Dombrovski L, Najmanovich R, Tempel W, Dong A, Loppnau P, Martin F, Thornton J, Edwards AM, Bochkarev A, Plotnikov AN, Vedadi M, Arrowsmith CH: Structural and chemical profiling of the human cytosolic sulfotransferases. PLoS Biol. 2007 May;5(5):e97. doi: 10.1371/journal.pbio.0050097. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB00871 Terbutaline approved unknown substrate Details DB00960 Pindolol approved, investigational unknown substrate Details DB00968 Methyldopa approved no substrate Details DB12471 Ibrexafungerp approved, investigational unknown substrate Details DB00867 Ritodrine approved, investigational no substrate Details DB12243 Edaravone approved, investigational no substrate Details