All-trans-retinol 13,14-reductase

Details

Name
All-trans-retinol 13,14-reductase
Synonyms
  • 1.3.99.23
  • All-trans-13,14-dihydroretinol saturase
  • PPAR-alpha-regulated and starvation-induced gene protein
  • PPSIG
  • RetSat
Gene Name
RETSAT
Organism
Humans
Amino acid sequence
>lcl|BSEQ0004556|All-trans-retinol 13,14-reductase
MWLPLVLLLAVLLLAVLCKVYLGLFSGSSPNPFSEDVKRPPAPLVTDKEARKKVLKQAFS
ANQVPEKLDVVVIGSGFGGLAAAAILAKAGKRVLVLEQHTKAGGCCHTFGKNGLEFDTGI
HYIGRMEEGSIGRFILDQITEGQLDWAPLSSPFDIMVLEGPNGRKEYPMYSGEKAYIQGL
KEKFPQEEAIIDKYIKLVKVVSSGAPHAILLKFLPLPVVQLLDRCGLLTRFSPFLQASTQ
SLAEVLQQLGASSELQAVLSYIFPTYGVTPNHSAFSMHALLVNHYMKGGFYPRGGSSEIA
FHTIPVIQRAGGAVLTKATVQSVLLDSAGKACGVSVKKGHELVNIYCPIVVSNAGLFNTY
EHLLPGNARCLPGVKQQLGTVRPGLGMTSVFICLRGTKEDLHLPSTNYYVYYDTDMDQAM
ERYVSMPREEAAEHIPLLFFAFPSAKDPTWEDRFPGRSTMIMLIPTAYEWFEEWQAELKG
KRGSDYETFKNSFVEASMSVVLKLFPQLEGKVESVTAGSPLTNQFYLAAPRGACYGADHD
LGRLHPCVMASLRAQSPIPNLYLTGQDIFTCGLVGALQGALLCSSAILKRNLYSDLKNLD
SRIRAQKKKN
Number of residues
610
Molecular Weight
66818.935
Theoretical pI
8.39
GO Classification
Functions
all-trans-retinol 13,14-reductase activity / oxidoreductase activity
Processes
oxidation-reduction process / retinol metabolic process
Components
endoplasmic reticulum membrane / membrane / nuclear membrane / nuclear outer membrane
General Function
Oxidoreductase activity
Specific Function
Retinol saturase carrying out the saturation of the 13-14 double bond of all-trans-retinol to produce all-trans-13,14-dihydroretinol. Has activity toward all-trans-retinol as substrate. Does not use all-trans-retinoic acid nor 9-cis, 11-cis or 13-cis-retinol isomers as substrates. May play a role in the metabolism of vitamin A (By similarity).
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Endoplasmic reticulum membrane
Gene sequence
>lcl|BSEQ0011670|All-trans-retinol 13,14-reductase (RETSAT)
ATGTGGCTTCCGCTGGTGCTGCTCCTGGCTGTGCTGCTGCTGGCCGTCCTCTGCAAAGTT
TACTTGGGACTATTCTCTGGCAGCTCCCCGAATCCTTTCTCCGAAGATGTCAAACGGCCC
CCAGCGCCCCTGGTAACTGACAAGGAGGCCAGGAAGAAGGTTCTCAAACAAGCTTTTTCA
GCCAACCAAGTGCCGGAGAAGCTGGATGTGGTGGTAATTGGCAGTGGCTTTGGGGGCCTG
GCTGCAGCTGCAATTCTAGCTAAAGCTGGCAAGCGAGTCCTGGTGCTGGAACAACATACC
AAGGCAGGGGGCTGCTGTCATACCTTTGGAAAGAATGGCCTTGAATTTGACACAGGAATC
CATTACATTGGGCGTATGGAAGAGGGCAGCATTGGCCGTTTTATCTTGGACCAGATCACT
GAAGGGCAGCTGGACTGGGCTCCCCTGTCCTCTCCTTTTGACATCATGGTACTGGAAGGG
CCCAATGGCCGAAAGGAGTACCCCATGTACAGTGGAGAGAAAGCCTACATTCAGGGCCTC
AAGGAGAAGTTTCCACAGGAGGAAGCTATCATTGACAAGTATATAAAGCTGGTTAAGGTG
GTATCCAGTGGAGCCCCTCATGCCATCCTGTTGAAATTCCTCCCATTGCCCGTGGTTCAG
CTCCTCGACAGGTGTGGGCTGCTGACTCGTTTCTCTCCATTCCTTCAAGCATCCACCCAG
AGCCTGGCTGAGGTCCTGCAGCAGCTGGGGGCCTCCTCTGAGCTCCAGGCAGTACTCAGC
TACATCTTCCCCACTTACGGTGTCACCCCCAACCACAGTGCCTTTTCCATGCACGCCCTG
CTGGTCAACCACTACATGAAAGGAGGCTTTTATCCCCGAGGGGGTTCCAGTGAAATTGCC
TTCCACACCATCCCTGTGATTCAGCGGGCTGGGGGCGCTGTCCTCACAAAGGCCACTGTG
CAGAGTGTGTTGCTGGACTCAGCTGGGAAAGCCTGTGGTGTCAGTGTGAAGAAGGGGCAT
GAGCTGGTGAACATCTATTGCCCCATCGTGGTCTCCAACGCAGGACTGTTCAACACCTAT
GAACACCTACTGCCGGGGAACGCCCGCTGCCTGCCAGGTGTGAAGCAGCAACTGGGGACG
GTGCGGCCCGGCTTAGGCATGACCTCTGTTTTCATCTGCCTGCGAGGCACCAAGGAAGAC
CTGCATCTGCCGTCCACCAACTACTATGTTTACTATGACACGGACATGGACCAGGCGATG
GAGCGCTACGTCTCCATGCCCAGGGAAGAGGCTGCGGAACACATCCCTCTTCTCTTCTTC
GCTTTCCCATCAGCCAAAGATCCGACCTGGGAGGACCGATTCCCAGGCCGGTCCACCATG
ATCATGCTCATACCCACTGCCTACGAGTGGTTTGAGGAGTGGCAGGCGGAGCTGAAGGGA
AAGCGGGGCAGTGACTATGAGACCTTCAAAAACTCCTTTGTGGAAGCCTCTATGTCAGTG
GTCCTGAAACTGTTCCCACAGCTGGAGGGGAAGGTGGAGAGTGTGACTGCAGGATCCCCA
CTCACCAACCAGTTCTATCTGGCTGCTCCCCGAGGTGCCTGCTACGGGGCTGACCATGAC
CTGGGCCGCCTGCACCCTTGTGTGATGGCCTCCTTGAGGGCCCAGAGCCCCATCCCCAAC
CTCTATCTGACAGGCCAGGATATCTTCACCTGTGGACTGGTCGGGGCCCTGCAAGGTGCC
CTGCTGTGCAGCAGCGCCATCCTGAAGCGGAACTTGTACTCAGACCTTAAGAATCTTGAT
TCTAGGATCCGGGCACAGAAGAAAAAGAATTAG
Chromosome Location
2
Locus
2p11.2
External Identifiers
ResourceLink
UniProtKB IDQ6NUM9
UniProtKB Entry NameRETST_HUMAN
GenBank Protein ID37182258
GenBank Gene IDAY358568
GenAtlas IDRETSAT
HGNC IDHGNC:25991
General References
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  2. Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T: Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. DNA Res. 2005;12(2):117-26. [Article]
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00162Vitamin Aapproved, nutraceutical, vet_approvedunknownsubstrateDetails