Iodotyrosine deiodinase 1
Details
- Name
- Iodotyrosine deiodinase 1
- Synonyms
- 1.21.1.1
- C6orf71
- DEHAL1
- Iodotyrosine dehalogenase 1
- IYD-1
- Gene Name
- IYD
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0008302|Iodotyrosine deiodinase 1 MYFLTPILVAILCILVVWIFKNADRSMEKKKGEPRTRAEARPWVDEDLKDSSDLHQAEED ADEWQESEENVEHIPFSHNHYPEKEMVKRSQEFYELLNKRRSVRFISNEQVPMEVIDNVI RTAGTAPSGAHTEPWTFVVVKDPDVKHKIRKIIEEEEEINYMKRMGHRWVTDLKKLRTNW IKEYLDTAPILILIFKQVHGFAANGKKKVHYYNEISVSIACGILLAALQNAGLVTVTTTP LNCGPRLRVLLGRPAHEKLLMLLPVGYPSKEATVPDLKRKPLDQIMVTV
- Number of residues
- 289
- Molecular Weight
- 33359.41
- Theoretical pI
- 7.71
- GO Classification
- Functionsiodide peroxidase activity / oxidoreductase activityProcessescellular nitrogen compound metabolic process / small molecule metabolic process / thyroid hormone generationComponentsintegral component of membrane / plasma membrane
- General Function
- Oxidoreductase activity
- Specific Function
- Catalyzes the oxidative NADPH-dependent deiodination of monoiodotyrosine (L-MIT) or diiodotyrosine (L-DIT). Acts during the hydrolysis of thyroglobulin to liberate iodide, which can then reenter the hormone-producing pathways. Acts more efficiently on monoiodotyrosine than on diiodotyrosine.
- Pfam Domain Function
- Nitroreductase (PF00881)
- Transmembrane Regions
- 215-235
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0019568|Iodotyrosine deiodinase 1 (IYD) ATGTATTTCCTGACTCCCATCTTGGTAGCCATTCTCTGCATTTTGGTTGTGTGGATCTTT AAAAATGCCGACAGAAGCATGGAGAAAAAGAAGGGGGAGCCTAGAACCAGGGCCGAAGCT CGCCCCTGGGTGGATGAAGACTTAAAAGACAGCAGTGACCTGCACCAAGCAGAAGAAGAT GCTGATGAATGGCAAGAATCAGAAGAAAATGTTGAACACATCCCCTTCTCTCATAACCAC TATCCTGAGAAGGAAATGGTTAAGAGGTCTCAGGAATTTTATGAACTTCTCAATAAGAGA CGGTCAGTCAGGTTCATAAGTAATGAGCAAGTCCCAATGGAAGTCATTGATAATGTCATC AGAACGGCAGGAACAGCCCCGAGTGGGGCTCACACAGAGCCCTGGACCTTCGTGGTTGTG AAGGACCCAGACGTGAAGCACAAGATTCGAAAGATCATTGAGGAGGAAGAGGAGATCAAC TACATGAAAAGGATGGGACATCGCTGGGTCACAGACCTCAAGAAACTGAGAACCAACTGG ATTAAAGAGTACTTGGATACTGCCCCTATTTTGATTCTCATTTTCAAACAAGTACATGGT TTCGCCGCAAATGGCAAGAAAAAAGTCCACTACTACAATGAGATCAGTGTTTCCATCGCT TGTGGCATCCTGCTAGCTGCCCTGCAGGTAAATAATGGAATCACCATGCGGCATCAGACT GCGAGGCACCGCCACCTGATTGAGGGTCCTGGAAGAAGCAGCGAAGCCTGCAGCAAGCTC AGCTCACAAGGCTGCCCAGAATGCAGGTCTGGTGACTGTCACTACCACTCCTCTCAACTG TGGCCCTCGACTGAGGGTGCTCCTGGGCCGCCCCGCACATGA
- Chromosome Location
- 6
- Locus
- 6q25.1
- External Identifiers
Resource Link UniProtKB ID Q6PHW0 UniProtKB Entry Name IYD1_HUMAN GenBank Protein ID 31322698 GenBank Gene ID AY259176 HGNC ID HGNC:21071 - General References
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