Zinc transporter ZIP5
Details
- Name
- Zinc transporter ZIP5
- Synonyms
- Solute carrier family 39 member 5
- ZIP-5
- ZIP5
- Zrt- and Irt-like protein 5
- Gene Name
- SLC39A5
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0052339|Zinc transporter ZIP5 MMGSPVSHLLAGFCVWVVLGWVGGSVPNLGPAEQEQNHYLAQLFGLYGENGTLTAGGLAR LLHSLGLGRVQGLRLGQHGPLTGRAASPAADNSTHRPQNPELSVDVWAGMPLGPSGWGDL EESKAPHLPRGPAPSGLDLLHRLLLLDHSLADHLNEDCLNGSQLLVNFGLSPAAPLTPRQ FALLCPALLYQIDSRVCIGAPAPAPPGDLLSALLQSALAVLLLSLPSPLSLLLLRLLGPR LLRPLLGFLGALAVGTLCGDALLHLLPHAQEGRHAGPGGLPEKDLGPGLSVLGGLFLLFV LENMLGLLRHRGLRPRCCRRKRRNLETRNLDPENGSGMALQPLQAAPEPGAQGQREKNSQ HPPALAPPGHQGHSHGHQGGTDITWMVLLGDGLHNLTDGLAIGAAFSDGFSSGLSTTLAV FCHELPHELGDFAMLLQSGLSFRRLLLLSLVSGALGLGGAVLGVGLSLGPVPLTPWVFGV TAGVFLYVALVDMLPALLRPPEPLPTPHVLLQGLGLLLGGGLMLAITLLEERLLPVTTEG
- Number of residues
- 540
- Molecular Weight
- 56460.165
- Theoretical pI
- Not Available
- GO Classification
- Functionszinc ion transmembrane transporter activityProcessesBMP signaling pathway / cellular response to zinc ion starvation / cellular zinc ion homeostasis / eye development / G1 to G0 transition involved in cell differentiation / neural precursor cell proliferation / positive regulation of mRNA splicing, via spliceosome / zinc ion import across plasma membraneComponentsbasolateral plasma membrane / cell / extracellular exosome / integral component of plasma membrane
- General Function
- May play a role in polarized cells by carrying out serosal-to-mucosal zinc transport. Plays a role in eye development. Could regulate the BMP/TGF-beta (bone morphogenetic protein/transforming growth factor-beta) signaling pathway and modulates extracellular matrix (ECM) proteins of the sclera (PubMed:24891338). Seems to play a central role in controlling organismal zinc status (By similarity).
- Specific Function
- Zinc ion transmembrane transporter activity
- Pfam Domain Function
- Zip (PF02535)
- Transmembrane Regions
- 213-233 245-265 288-308 445-465 471-491 509-529
- Cellular Location
- Basolateral cell membrane
- Gene sequence
>lcl|BSEQ0052340|Zinc transporter ZIP5 (SLC39A5) ATGATGGGGTCCCCAGTGAGTCATCTGCTGGCCGGCTTCTGTGTGTGGGTCGTCTTGGGC TGGGTAGGGGGCTCAGTCCCCAACCTGGGCCCTGCTGAGCAGGAGCAGAACCATTACCTG GCCCAGCTGTTTGGCCTGTACGGCGAGAATGGGACGCTGACTGCAGGGGGCTTGGCGCGG CTTCTCCACAGCCTGGGGCTAGGCCGAGTTCAGGGGCTTCGCCTGGGACAGCATGGGCCT CTGACTGGACGGGCTGCATCCCCAGCTGCAGACAATTCCACACACAGGCCACAGAACCCT GAGCTGAGTGTGGATGTCTGGGCAGGGATGCCTCTGGGTCCCTCAGGGTGGGGTGACCTG GAAGAGTCAAAGGCCCCTCACCTACCCCGTGGGCCAGCCCCCTCGGGCCTGGACCTCCTT CACAGGCTTCTGTTGCTGGACCACTCATTGGCTGACCACCTGAATGAGGATTGTCTGAAC GGCTCCCAGCTGCTGGTCAATTTTGGCTTGAGCCCCGCTGCTCCTCTGACCCCTCGTCAG TTTGCTCTGCTGTGCCCAGCCCTGCTTTATCAGATCGACAGCCGCGTCTGCATCGGCGCT CCGGCCCCTGCACCCCCAGGGGATCTACTATCTGCCCTGCTTCAGAGTGCCCTGGCAGTC CTGTTGCTCAGCCTCCCTTCTCCCCTATCCCTGCTGCTGCTGCGGCTCCTGGGACCTCGT CTACTACGGCCCTTGCTGGGCTTCCTGGGGGCCCTGGCGGTGGGCACTCTTTGTGGGGAT GCACTGCTACATCTGCTACCGCATGCACAAGAAGGGCGGCACGCAGGACCTGGCGGACTA CCAGAGAAGGACCTGGGCCCGGGGCTGTCAGTGCTCGGAGGCCTCTTCCTGCTCTTTGTG CTGGAGAACATGCTGGGGCTTTTGCGGCACCGAGGGCTCAGGCCAAGATGCTGCAGGCGA AAACGAAGGAATCTCGAAACACGCAACTTGGATCCGGAGAATGGCAGTGGGATGGCCCTT CAGCCCCTACAGGCAGCTCCAGAGCCAGGGGCTCAGGGCCAGAGGGAGAAGAACAGCCAG CACCCACCAGCTCTGGCCCCTCCTGGGCACCAAGGCCACAGTCATGGGCACCAGGGTGGC ACTGATATCACGTGGATGGTCCTCCTGGGAGATGGTCTACACAACCTCACTGATGGGCTG GCCATAGGTGCTGCCTTCTCTGATGGCTTCTCCAGCGGCCTCAGTACCACCTTAGCGGTC TTCTGCCATGAGCTGCCCCACGAACTGGGTGACTTTGCCATGCTGCTCCAGTCAGGGCTG TCCTTTCGGCGGCTGCTGCTGCTGAGCCTCGTGTCTGGAGCCCTGGGATTGGGGGGTGCA GTCCTGGGGGTGGGGCTCAGCCTGGGCCCTGTCCCCCTCACTCCCTGGGTGTTTGGGGTC ACTGCTGGGGTCTTCCTCTATGTGGCCCTTGTGGACATGCTACCAGCCCTGCTTCGTCCT CCGGAGCCCCTGCCTACGCCCCATGTGCTCCTGCAGGGGCTGGGGCTGCTGCTGGGGGGC GGCCTCATGCTTGCCATAACCCTGCTGGAGGAGCGGCTACTGCCCGTGACCACTGAGGGC TGA
- Chromosome Location
- 12
- Locus
- 12q13.3
- External Identifiers
Resource Link UniProtKB ID Q6ZMH5 UniProtKB Entry Name S39A5_HUMAN HGNC ID HGNC:20502 - General References
- Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
- Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
- Wang F, Kim BE, Petris MJ, Eide DJ: The mammalian Zip5 protein is a zinc transporter that localizes to the basolateral surface of polarized cells. J Biol Chem. 2004 Dec 3;279(49):51433-41. doi: 10.1074/jbc.M408361200. Epub 2004 Aug 20. [Article]
- Guo H, Jin X, Zhu T, Wang T, Tong P, Tian L, Peng Y, Sun L, Wan A, Chen J, Liu Y, Li Y, Tian Q, Xia L, Zhang L, Pan Y, Lu L, Liu Q, Shen L, Li Y, Xiong W, Li J, Tang B, Feng Y, Zhang X, Zhang Z, Pan Q, Hu Z, Xia K: SLC39A5 mutations interfering with the BMP/TGF-beta pathway in non-syndromic high myopia. J Med Genet. 2014 Aug;51(8):518-25. doi: 10.1136/jmedgenet-2014-102351. Epub 2014 Jun 2. [Article]
- Jiang D, Li J, Xiao X, Li S, Jia X, Sun W, Guo X, Zhang Q: Detection of mutations in LRPAP1, CTSH, LEPREL1, ZNF644, SLC39A5, and SCO2 in 298 families with early-onset high myopia by exome sequencing. Invest Ophthalmol Vis Sci. 2014 Dec 18;56(1):339-45. doi: 10.1167/iovs.14-14850. [Article]