Mitogen-activated protein kinase kinase kinase 15

Details

Name
Mitogen-activated protein kinase kinase kinase 15
Synonyms
  • 2.7.11.25
  • Apoptosis signal-regulating kinase 3
  • ASK3
  • MAPK/ERK kinase kinase 15
  • MEK kinase 15
  • MEKK 15
Gene Name
MAP3K15
Organism
Humans
Amino acid sequence
>lcl|BSEQ0051810|Mitogen-activated protein kinase kinase kinase 15
MESGGGNAPAGALGAASESPQCPPPPGVEGAAGPAEPDGAAEGAAGGSGEGESGGGPRRA
LRAVYVRSESSQGGAAGGPEAGARQCLLRACEAEGAHLTSVPFGELDFGETAVLDAFYDA
DVAVVDMSDVSRQPSLFYHLGVRESFDMANNVILYHDTDADTALSLKDMVTQKNTASSGN
YYFIPYIVTPCADYFCCESDAQRRASEYMQPNWDNILGPLCMPLVDRFISLLKDIHVTSC
VYYKETLLNDIRKAREKYQGEELAKELARIKLRMDNTEVLTSDIIINLLLSYRDIQDYDA
MVKLVETLEMLPTCDLADQHNIKFHYAFALNRRNSTGDREKALQIMLQVLQSCDHPGPDM
FCLCGRIYKDIFLDSDCKDDTSRDSAIEWYRKGFELQSSLYSGINLAVLLIVAGQQFETS
LELRKIGVRLNSLLGRKGSLEKMNNYWDVGQFFSVSMLAHDVGKAVQAAERLFKLKPPVW
YLRSLVQNLLLIRRFKKTIIEHSPRQERLNFWLDIIFEATNEVTNGLRFPVLVIEPTKVY
QPSYVSINNEAEERTVSLWHVSPTEMKQMHEWNFTASSIKGISLSKFDERCCFLYVHDNS
DDFQIYFSTEEQCSRFFSLVKEMITNTAGSTVELEGETDGDTLEYEYDHDANGERVVLGK
GTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKYLKHRNIVQYLGSVSENG
YIKIFMEQVPGGSLSALLRSKWGPMKEPTIKFYTKQILEGLKYLHENQIVHRDIKGDNVL
VNTYSGVVKISDFGTSKRLAGVNPCTETFTGTLQYMAPEIIDQGPRGYGAPADIWSLGCT
IIEMATSKPPFHELGEPQAAMFKVGMFKIHPEIPEALSAEARAFILSCFEPDPHKRATTA
ELLREGFLRQVNKGKKNRIAFKPSEGPRGVVLALPTQGEPMATSSSEHGSVSPDSDAQPD
ALFERTRAPRHHLGHLLSVPDESSALEDRGLASSPEDRDQGLFLLRKDSERRAILYKILW
EEQNQVASNLQECVAQSSEELHLSVGHIKQIIGILRDFIRSPEHRVMATTISKLKVDLDF
DSSSISQIHLVLFGFQDAVNKILRNHLIRPHWMFAMDNIIRRAVQAAVTILIPELRAHFE
PTCETEGVDKDMDEAEEGYPPATGPGQEAQPHQQHLSLQLGELRQETNRLLEHLVEKERE
YQNLLRQTLEQKTQELYHLQLKLKSNCITENPAGPYGQRTDKELIDWLRLQGADAKTIEK
IVEEGYTLSDILNEITKEDLRYLRLRGGLLCRLWSAVSQYRRAQEASETKDKA
Number of residues
1313
Molecular Weight
147435.68
Theoretical pI
Not Available
GO Classification
Functions
ATP binding / MAP kinase kinase kinase activity / metal ion binding
Processes
activation of MAPKK activity
Components
intracellular
General Function
May function in a signal transduction pathway that is activated by various cell stresses and leads to apoptosis.
Specific Function
Atp binding
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0051811|Mitogen-activated protein kinase kinase kinase 15 (MAP3K15)
ATGGAGAGCGGCGGTGGGAATGCTCCGGCCGGGGCCCTCGGGGCGGCGAGCGAGTCCCCT
CAGTGCCCGCCGCCGCCGGGGGTGGAGGGCGCGGCCGGGCCGGCGGAGCCCGACGGGGCG
GCGGAGGGCGCGGCAGGCGGCAGCGGCGAGGGCGAGAGTGGGGGCGGGCCGCGGCGGGCT
CTGCGGGCAGTATACGTGCGCAGTGAGAGCTCCCAGGGCGGCGCGGCCGGCGGCCCGGAG
GCTGGGGCGCGGCAGTGCCTGCTGCGGGCCTGCGAGGCCGAGGGCGCTCACCTCACCTCC
GTGCCCTTCGGGGAGCTGGACTTCGGGGAGACGGCCGTGCTCGACGCCTTCTACGACGCA
GATGTTGCTGTGGTAGACATGAGCGATGTCTCCAGACAGCCTTCCCTCTTCTACCATCTT
GGAGTCCGAGAAAGCTTTGACATGGCCAATAATGTGATCTTGTACCATGACACCGATGCC
GACACTGCTCTCTCTTTGAAGGACATGGTAACTCAAAAAAACACAGCATCCAGTGGAAAT
TATTATTTCATCCCATACATCGTGACACCGTGCGCTGATTATTTTTGCTGCGAGAGTGAT
GCCCAGAGACGAGCCTCCGAGTACATGCAGCCCAACTGGGACAACATCCTGGGCCCGCTG
TGCATGCCTTTGGTGGACAGGTTCATTAGCCTCCTTAAGGACATCCACGTGACCTCATGT
GTTTATTACAAAGAAACCTTGTTAAATGACATCCGGAAAGCCAGAGAGAAATACCAAGGT
GAGGAACTGGCGAAGGAGCTAGCTCGGATCAAGCTCCGCATGGATAATACTGAGGTTCTG
ACCTCAGACATCATCATTAACTTACTCCTGTCCTACCGTGATATCCAGGACTATGATGCG
ATGGTGAAGCTGGTGGAAACACTGGAGATGCTGCCTACGTGTGATTTGGCCGATCAGCAT
AACATTAAATTCCACTATGCGTTTGCACTGAATAGGAGAAACAGCACAGGTGACCGTGAG
AAGGCTCTGCAGATCATGCTCCAGGTTCTGCAGAGCTGTGATCACCCGGGCCCCGACATG
TTCTGCCTGTGTGGGAGGATCTACAAGGACATCTTCTTGGATTCAGACTGCAAAGATGAC
ACCAGCCGCGACAGCGCCATTGAGTGGTATCGCAAAGGGTTTGAACTCCAGTCATCCCTC
TATTCGGGAATTAATCTTGCAGTTTTGCTGATTGTTGCTGGACAACAATTTGAAACTTCC
TTGGAACTAAGGAAAATAGGTGTCCGGCTGAACAGTTTGTTGGGAAGAAAAGGGAGCTTG
GAGAAAATGAACAATTACTGGGATGTGGGTCAGTTCTTCAGCGTCAGCATGCTGGCCCAT
GATGTCGGGAAAGCCGTCCAGGCAGCAGAGAGGTTGTTCAAACTGAAACCTCCAGTCTGG
TACCTGCGATCATTAGTTCAGAACTTGTTACTAATTCGGCGCTTCAAGAAAACCATTATT
GAACACTCGCCCAGGCAAGAGCGGCTGAACTTCTGGTTAGATATAATTTTTGAGGCAACA
AATGAAGTCACTAATGGACTCAGATTTCCAGTTCTGGTCATAGAGCCAACCAAAGTGTAC
CAGCCTTCTTATGTTTCCATAAACAATGAAGCCGAGGAGAGAACAGTTTCTTTATGGCAT
GTCTCACCCACAGAAATGAAACAGATGCACGAATGGAATTTTACAGCCTCTTCCATAAAG
GGAATAAGCCTATCAAAGTTTGATGAAAGGTGTTGTTTTCTTTATGTCCATGATAATTCT
GATGACTTTCAAATCTACTTTTCCACCGAAGAGCAGTGCAGTAGATTTTTCTCTTTGGTC
AAAGAGATGATAACCAATACAGCAGGCAGTACGGTGGAGCTGGAGGGAGAGACCGATGGA
GACACCTTGGAGTATGAGTATGACCATGATGCAAATGGTGAGAGAGTTGTCTTGGGGAAA
GGCACGTATGGGATTGTGTATGCTGGCCGAGATCTGAGCAATCAAGTGCGAATAGCCATC
AAAGAAATCCCGGAGAGAGATAGCAGGTATTCTCAGCCTCTGCACGAGGAGATAGCCCTG
CACAAGTACCTTAAGCACCGCAATATCGTTCAGTACCTGGGCTCTGTTTCAGAGAACGGC
TACATTAAGATATTTATGGAGCAGGTGCCTGGAGGAAGCCTTTCTGCTCTTCTGCGATCC
AAATGGGGGCCGATGAAGGAACCGACAATCAAGTTTTACACCAAACAGATCCTGGAGGGC
CTTAAGTATCTTCATGAAAACCAGATCGTGCACAGAGACATAAAGGGCGATAATGTTCTG
GTGAACACCTACAGCGGAGTGGTGAAAATCTCCGATTTTGGAACCTCGAAACGTCTTGCG
GGTGTGAACCCCTGCACAGAGACTTTTACTGGCACCCTGCAGTACATGGCACCTGAGATA
ATTGACCAAGGGCCTCGCGGATATGGTGCCCCAGCCGATATCTGGTCCCTGGGCTGCACC
ATCATTGAGATGGCCACCAGCAAGCCTCCGTTCCATGAGCTTGGTGAGCCGCAGGCAGCC
ATGTTCAAAGTGGGCATGTTTAAGATCCACCCTGAGATTCCAGAAGCCCTTTCAGCTGAA
GCCCGAGCCTTCATTTTATCCTGTTTCGAGCCTGACCCCCACAAACGTGCCACCACTGCT
GAGCTACTGAGAGAGGGTTTCTTAAGGCAGGTGAACAAGGGCAAGAAGAACCGAATTGCC
TTCAAGCCCTCAGAAGGTCCCCGCGGTGTCGTCCTGGCCCTGCCCACACAGGGAGAGCCC
ATGGCCACCAGCAGCAGCGAGCACGGCTCTGTCTCCCCAGACTCCGACGCCCAGCCTGAC
GCACTCTTTGAGAGGACCCGGGCGCCCAGGCACCACCTTGGCCACCTCCTCAGTGTTCCA
GACGAGAGCTCAGCCTTGGAAGACCGGGGCTTGGCCTCGTCCCCGGAGGACAGGGACCAG
GGCCTCTTCCTGCTACGCAAGGACAGTGAGCGCCGTGCCATCCTGTACAAAATCCTCTGG
GAGGAGCAGAACCAGGTGGCTTCCAACCTGCAGGAGTGTGTGGCCCAGAGTTCCGAAGAG
TTGCATCTCTCAGTTGGACACATCAAGCAAATCATTGGGATCCTGAGGGACTTCATCCGC
TCCCCAGAGCACCGGGTGATGGCGACCACAATATCAAAGCTCAAGGTGGACCTGGACTTT
GACAGCTCGTCCATCAGTCAGATTCACCTGGTGCTGTTCGGATTTCAGGATGCCGTAAAT
AAAATTTTGAGGAACCACTTAATTAGGCCCCACTGGATGTTCGCGATGGACAACATCATC
CGCCGAGCGGTGCAGGCCGCGGTCACCATTCTCATCCCAGAGCTCCGAGCCCACTTTGAG
CCTACCTGTGAGACTGAAGGGGTAGATAAGGACATGGATGAAGCGGAAGAGGGCTATCCC
CCAGCCACCGGACCTGGCCAGGAGGCCCAGCCCCACCAGCAGCACCTGAGCCTCCAGCTG
GGTGAGCTCAGACAGGAGACCAACAGACTTTTGGAACACCTAGTTGAAAAAGAGAGAGAG
TACCAGAATCTTCTGCGGCAAACTCTAGAACAGAAAACTCAAGAATTGTATCACCTTCAG
TTAAAATTAAAATCGAATTGTATTACAGAGAACCCAGCAGGCCCCTACGGGCAGAGAACA
GATAAAGAGCTTATAGACTGGTTGCGGCTGCAAGGAGCTGATGCAAAGACAATTGAAAAG
ATTGTTGAAGAGGGTTATACACTTTCGGATATTCTTAATGAGATCACTAAGGAAGATCTA
AGATACCTTCGACTACGGGGTGGTCTCCTCTGCAGACTCTGGAGTGCGGTCTCCCAGTAC
AGAAGGGCTCAGGAGGCCTCAGAAACCAAAGACAAGGCTTGA
Chromosome Location
X
Locus
Xp22.12
External Identifiers
ResourceLink
UniProtKB IDQ6ZN16
UniProtKB Entry NameM3K15_HUMAN
HGNC IDHGNC:31689
General References
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB12010Fostamatinibapproved, investigationalunknowninhibitorDetails