Peptidyl-prolyl cis-trans isomerase

Details

Name
Peptidyl-prolyl cis-trans isomerase
Synonyms
  • 5.2.1.8
  • PPIase
Gene Name
Not Available
Organism
Plasmodium falciparum (isolate 3D7)
Amino acid sequence
>lcl|BSEQ0051442|Peptidyl-prolyl cis-trans isomerase
MSKRSKVFFDISIDNSNAGRIIFELFSDITPRTCENFRALCTGEKIGSRGKNLHYKNSIF
HRIIPQFMCQGGDITNGNGSGGESIYGRSFTDENFNMKHDQPGLLSMANAGPNTNSSQFF
ITLVPCPWLDGKHVVFGKVIEGMNVVREMEKEGAKSGYVKRSVVITDCGEL
Number of residues
171
Molecular Weight
18952.44
Theoretical pI
Not Available
GO Classification
Functions
cyclosporin A binding / peptidyl-prolyl cis-trans isomerase activity
Processes
protein folding
Components
cytosol
General Function
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Specific Function
Cyclosporin a binding
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0051443|Peptidyl-prolyl cis-trans isomerase
ATGAGTAAGAGGAGTAAAGTTTTTTTTGATATATCTATTGACAATAGTAATGCTGGAAGA
ATAATTTTTGAATTATTCAGTGATATAACTCCTAGAACCTGTGAAAACTTTAGAGCTTTA
TGTACAGGTGAAAAAATAGGATCAAGAGGTAAAAACTTACATTACAAAAATTCAATATTC
CATAGAATTATTCCTCAATTTATGTGTCAAGGAGGTGATATTACAAATGGAAATGGATCA
GGAGGAGAATCAATATATGGAAGATCTTTTACGGATGAAAATTTTAATATGAAACATGAT
CAACCAGGATTATTATCTATGGCAAATGCTGGACCAAATACCAACTCATCACAATTCTTT
ATCACCTTAGTACCTTGCCCATGGTTAGATGGTAAACATGTTGTTTTTGGAAAAGTTATC
GAAGGTATGAATGTTGTTAGAGAAATGGAAAAGGAAGGAGCAAAAAGTGGATACGTCAAA
AGATCTGTAGTAATAACTGATTGTGGTGAATTGTAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ76NN7
UniProtKB Entry NameQ76NN7_PLAF7
General References
  1. Bowman S, Lawson D, Basham D, Brown D, Chillingworth T, Churcher CM, Craig A, Davies RM, Devlin K, Feltwell T, Gentles S, Gwilliam R, Hamlin N, Harris D, Holroyd S, Hornsby T, Horrocks P, Jagels K, Jassal B, Kyes S, McLean J, Moule S, Mungall K, Murphy L, Oliver K, Quail MA, Rajandream MA, Rutter S, Skelton J, Squares R, Squares S, Sulston JE, Whitehead S, Woodward JR, Newbold C, Barrell BG: The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. Nature. 1999 Aug 5;400(6744):532-8. doi: 10.1038/22964. [Article]
  2. Gardner MJ, Hall N, Fung E, White O, Berriman M, Hyman RW, Carlton JM, Pain A, Nelson KE, Bowman S, Paulsen IT, James K, Eisen JA, Rutherford K, Salzberg SL, Craig A, Kyes S, Chan MS, Nene V, Shallom SJ, Suh B, Peterson J, Angiuoli S, Pertea M, Allen J, Selengut J, Haft D, Mather MW, Vaidya AB, Martin DM, Fairlamb AH, Fraunholz MJ, Roos DS, Ralph SA, McFadden GI, Cummings LM, Subramanian GM, Mungall C, Venter JC, Carucci DJ, Hoffman SL, Newbold C, Davis RW, Fraser CM, Barrell B: Genome sequence of the human malaria parasite Plasmodium falciparum. Nature. 2002 Oct 3;419(6906):498-511. [Article]
  3. Hall N, Pain A, Berriman M, Churcher C, Harris B, Harris D, Mungall K, Bowman S, Atkin R, Baker S, Barron A, Brooks K, Buckee CO, Burrows C, Cherevach I, Chillingworth C, Chillingworth T, Christodoulou Z, Clark L, Clark R, Corton C, Cronin A, Davies R, Davis P, Dear P, Dearden F, Doggett J, Feltwell T, Goble A, Goodhead I, Gwilliam R, Hamlin N, Hance Z, Harper D, Hauser H, Hornsby T, Holroyd S, Horrocks P, Humphray S, Jagels K, James KD, Johnson D, Kerhornou A, Knights A, Konfortov B, Kyes S, Larke N, Lawson D, Lennard N, Line A, Maddison M, McLean J, Mooney P, Moule S, Murphy L, Oliver K, Ormond D, Price C, Quail MA, Rabbinowitsch E, Rajandream MA, Rutter S, Rutherford KM, Sanders M, Simmonds M, Seeger K, Sharp S, Smith R, Squares R, Squares S, Stevens K, Taylor K, Tivey A, Unwin L, Whitehead S, Woodward J, Sulston JE, Craig A, Newbold C, Barrell BG: Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Nature. 2002 Oct 3;419(6906):527-31. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB11638Artenimolapproved, experimental, investigationalunknownligandDetails