MecA

Details

Name
MecA
Synonyms
  • ftsI_1
  • ftsI_2
  • ftsI_3
  • mecA_1
  • Pencillin binding protein 2a (PBP 2a)
  • Penicilin-binding protein 2
  • Penicillin binding protein 2 prime
  • Penicillin binding protein 2'
  • Penicillin-binding protein 2
  • Penicillin-binding protein 2 prime
  • Penicillin-binding protein 2'
  • Penicillin-binding protein 2a
  • Peptidase
Gene Name
mecA
Organism
Staphylococcus aureus
Amino acid sequence
>lcl|BSEQ0022278|MecA
MKKIKIVPLILIVVVVGFGIYFYASKDKEINNTIDAIEDKNFKQVYKDSSYISKSDNGEV
EMTERPIKIYNSLGVKDINIQDRKIKKVSKNKKRVDAQYKIKTNYGNIDRNVQFNFVKED
GMWKLDWDHSVIIPGMQKDQSIHIENLKSERGKILDRNNVELANTGTAYEIGIVPKNVSK
KDYKAIAKELSISEDYIKQQMDQNWVQDDTFVPLKTVKKMDEYLSDFAKKFHLTTNETES
RNYPLGKATSHLLGYVGPINSEELKQKEYKGYKDDAVIGKKGLEKLYDKKLQHEDGYRVT
IVDDNSNTIAHTLIEKKKKDGKDIQLTIDAKVQKSIYNNMKNDYGSGTAIHPQTGELLAL
VSTPSYDVYPFMYGMSNEEYNKLTEDKKEPLLNKFQITTSPGSTQKILTAMIGLNNKTLD
DKTSYKIDGKGWQKDKSWGGYNVTRYEVVNGNIDLKQAIESSDNIFFARVALELGSKKFE
KGMKKLGVGEDIPSDYPFYNAQISNKNLDNEILLADSGYGQGEILINPVQILSIYSALEN
NGNINAPHLLKDTKNKVWKKNIISKENINLLTDGMQQVVNKTHKEDIYRSYANLIGKSGT
AELKMKQGETGRQIGWFISYDKDNPNMMMAINVKDVQDKGMASYNAKISGKVYDELYENG
NKKYDIDE
Number of residues
668
Molecular Weight
76102.075
Theoretical pI
9.19
GO Classification
Functions
penicillin binding / transferase activity, transferring glycosyl groups
Processes
response to antibiotic
Components
integral component of membrane
General Function
Transferase activity, transferring glycosyl groups
Specific Function
Not Available
Pfam Domain Function
Transmembrane Regions
7-24
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0004695|2007 bp
ATGAAAAAGATAAAAATTGTTCCACTTATTTTAATAGTTGTAGTTGTCGGGTTTGGTATA
TATTTTTATGCTTCAAAAGATAAAGAAATTAATAATACTATTGATGCAATTGAAGATAAA
AATTTCAAACAAGTTTATAAAGATAGCAGTTATATTTCTAAAAGCGATAATGGTGAAGTA
GAAATGACTGAACGTCCGATAAAAATATATAATAGTTTAGGCGTTAAAGATATAAACATT
CAGGATCGTAAAATAAAAAAAGTATCTAAAAATAAAAAACGAGTAGATGCTCAATATAAA
ATTAAAACAAACTACGGTAACATTGATCGCAACGTTCAATTTAATTTTGTTAAAGAAGAT
GGTATGTGGAAGTTAGATTGGGATCATAGCGTCATTATTCCAGGAATGCAGAAAGACCAA
AGCATACATATTGAAAATTTAAAATCAGAACGTGGTAAAATTTTAGACCGAAACAATGTG
GAATTGGCCAATACAGGAACAGCATATGAGATAGGCATCGTTCCAAAGAATGTATCTAAA
AAAGATTATAAAGCAATCGCTAAAGAACTAAGTATTTCTGAAGACTATATCAAACAACAA
ATGGATCAAAATTGGGTACAAGATGATACCTTCGTTCCACTTAAAACCGTTAAAAAAATG
GATGAATATTTAAGTGATTTCGCAAAAAAATTTCATCTTACAACTAATGAAACAGAAAGT
CGTAACTATCCTCTAGGAAAAGCGACTTCACATCTATTAGGTTATGTTGGTCCCATTAAC
TCTGAAGAATTAAAACAAAAAGAATATAAAGGCTATAAAGATGATGCAGTTATTGGTAAA
AAGGGACTCGAAAAACTTTACGATAAAAAGCTCCAACATGAAGATGGCTATCGTGTCACA
ATCGTTGACGATAATAGCAATACAATCGCACATACATTAATAGAGAAAAAGAAAAAAGAT
GGCAAAGATATTCAACTAACTATTGATGCTAAAGTTCAAAAGAGTATTTATAACAACATG
AAAAATGATTATGGCTCAGGTACTGCTATCCACCCTCAAACAGGTGAATTATTAGCACTT
GTAAGCACACCTTCATATGACGTCTATCCATTTATGTATGGCATGAGTAACGAAGAATAT
AATAAATTAACCGAAGATAAAAAAGAACCTCTGCTCAACAAGTTCCAGATTACAACTTCA
CCAGGTTCAACTCAAAAAATATTAACAGCAATGATTGGGTTAAATAACAAAACATTAGAC
GATAAAACAAGTTATAAAATCGATGGTAAAGGTTGGCAAAAAGATAAATCTTGGGGTGGT
TACAACGTTACAAGATATGAAGTGGTAAATGGTAATATCGACTTAAAACAAGCAATAGAA
TCATCAGATAACATTTTCTTTGCTAGAGTAGCACTCGAATTAGGCAGTAAGAAATTTGAA
AAAGGCATGAAAAAACTAGGTGTTGGTGAAGATATACCAAGTGATTATCCATTTTATAAT
GCTCAAATTTCAAACAAAAATTTAGATAATGAAATATTATTAGCTGATTCAGGTTACGGA
CAAGGTGAAATACTGATTAACCCAGTACAGATCCTTTCAATCTATAGCGCATTAGAAAAT
AATGGCAATATTAACGCACCTCACTTATTAAAAGACACGAAAAACAAAGTTTGGAAGAAA
AATATTATTTCCAAAGAAAATATCAATCTATTAACTGATGGTATGCAACAAGTCGTAAAT
AAAACACATAAAGAAGATATTTATAGATCTTATGCAAACTTAATTGGCAAATCCGGTACT
GCAGAACTCAAAATGAAACAAGGAGAAACTGGCAGACAAATTGGGTGGTTTATATCATAT
GATAAAGATAATCCAAACATGATGATGGCTATTAATGTTAAAGATGTACAAGATAAAGGA
ATGGCTAGCTACAATGCCAAAATCTCAGGTAAAGTGTATGATGAGCTATATGAGAACGGT
AATAAAAAATACGATATAGATGAATAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ7DHH4
UniProtKB Entry NameQ7DHH4_STAAU
GenBank Gene IDAB063172
General References
  1. Hiramatsu K, Asada K, Suzuki E, Okonogi K, Yokota T: Molecular cloning and nucleotide sequence determination of the regulator region of mecA gene in methicillin-resistant Staphylococcus aureus (MRSA). FEBS Lett. 1992 Feb 24;298(2-3):133-6. [Article]
  2. Ito T, Katayama Y, Hiramatsu K: Cloning and nucleotide sequence determination of the entire mec DNA of pre-methicillin-resistant Staphylococcus aureus N315. Antimicrob Agents Chemother. 1999 Jun;43(6):1449-58. [Article]
  3. Ito T, Katayama Y, Asada K, Mori N, Tsutsumimoto K, Tiensasitorn C, Hiramatsu K: Structural comparison of three types of staphylococcal cassette chromosome mec integrated in the chromosome in methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother. 2001 May;45(5):1323-36. [Article]
  4. Hiramatsu K, Cui L, Kuroda M, Ito T: The emergence and evolution of methicillin-resistant Staphylococcus aureus. Trends Microbiol. 2001 Oct;9(10):486-93. [Article]
  5. Ma XX, Ito T, Tiensasitorn C, Jamklang M, Chongtrakool P, Boyle-Vavra S, Daum RS, Hiramatsu K: Novel type of staphylococcal cassette chromosome mec identified in community-acquired methicillin-resistant Staphylococcus aureus strains. Antimicrob Agents Chemother. 2002 Apr;46(4):1147-52. [Article]
  6. Shore A, Rossney AS, Keane CT, Enright MC, Coleman DC: Seven novel variants of the staphylococcal chromosomal cassette mec in methicillin-resistant Staphylococcus aureus isolates from Ireland. Antimicrob Agents Chemother. 2005 May;49(5):2070-83. [Article]
  7. Taneike I, Otsuka T, Dohmae S, Saito K, Ozaki K, Takano M, Higuchi W, Takano T, Yamamoto T: Molecular nature of methicillin-resistant Staphylococcus aureus derived from explosive nosocomial outbreaks of the 1980s in Japan. FEBS Lett. 2006 Apr 17;580(9):2323-34. Epub 2006 Mar 29. [Article]
  8. Park C, Lee DG, Kim SW, Choi SM, Park SH, Chun HS, Choi JH, Yoo JH, Shin WS, Kang JH, Kim JH, Lee SY, Kim SM, Pyun BY: Predominance of community-associated methicillin-resistant Staphylococcus aureus strains carrying staphylococcal chromosome cassette mec type IVA in South Korea. J Clin Microbiol. 2007 Dec;45(12):4021-6. Epub 2007 Oct 17. [Article]
  9. Kishii K, Ito T, Watanabe S, Okuzumi K, Hiramatsu K: Recurrence of heterogeneous methicillin-resistant Staphylococcus aureus (MRSA) among the MRSA clinical isolates in a Japanese university hospital. J Antimicrob Chemother. 2008 Aug;62(2):324-8. doi: 10.1093/jac/dkn186. Epub 2008 May 7. [Article]
  10. Zhang K, McClure JA, Elsayed S, Conly JM: Novel staphylococcal cassette chromosome mec type, tentatively designated type VIII, harboring class A mec and type 4 ccr gene complexes in a Canadian epidemic strain of methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother. 2009 Feb;53(2):531-40. doi: 10.1128/AAC.01118-08. Epub 2008 Dec 8. [Article]
  11. Berglund C, Ito T, Ma XX, Ikeda M, Watanabe S, Soderquist B, Hiramatsu K: Genetic diversity of methicillin-resistant Staphylococcus aureus carrying type IV SCCmec in Orebro County and the western region of Sweden. J Antimicrob Chemother. 2009 Jan;63(1):32-41. doi: 10.1093/jac/dkn435. Epub 2008 Nov 11. [Article]
  12. Chen L, Mediavilla JR, Oliveira DC, Willey BM, de Lencastre H, Kreiswirth BN: Multiplex real-time PCR for rapid Staphylococcal cassette chromosome mec typing. J Clin Microbiol. 2009 Nov;47(11):3692-706. doi: 10.1128/JCM.00766-09. Epub 2009 Sep 2. [Article]
  13. Park C, Shin HH, Kwon EY, Choi SM, Kim SH, Park SH, Choi JH, Yoo JH, Lee DG, Shin WS: Two variants of staphylococcal cassette chromosome mec type IVA in community-associated meticillin-resistant Staphylococcus aureus strains in South Korea. J Med Microbiol. 2009 Oct;58(Pt 10):1314-21. doi: 10.1099/jmm.0.009688-0. Epub 2009 Jul 2. [Article]
  14. Jones RN, Mendes RE, Sader HS: Ceftaroline activity against pathogens associated with complicated skin and skin structure infections: results from an international surveillance study. J Antimicrob Chemother. 2010 Nov;65 Suppl 4:iv17-31. doi: 10.1093/jac/dkq252. [Article]
  15. Bartels MD, Hansen LH, Boye K, Sorensen SJ, Westh H: An unexpected location of the arginine catabolic mobile element (ACME) in a USA300-related MRSA strain. PLoS One. 2011 Jan 25;6(1):e16193. doi: 10.1371/journal.pone.0016193. [Article]
  16. Mendes RE, Tsakris A, Sader HS, Jones RN, Biek D, McGhee P, Appelbaum PC, Kosowska-Shick K: Characterization of methicillin-resistant Staphylococcus aureus displaying increased MICs of ceftaroline. J Antimicrob Chemother. 2012 Jun;67(6):1321-4. doi: 10.1093/jac/dks069. Epub 2012 Mar 7. [Article]
  17. Sabat AJ, Kock R, Akkerboom V, Hendrix R, Skov RL, Becker K, Friedrich AW: Novel organization of the arginine catabolic mobile element and staphylococcal cassette chromosome mec composite island and its horizontal transfer between distinct Staphylococcus aureus genotypes. Antimicrob Agents Chemother. 2013 Nov;57(11):5774-7. doi: 10.1128/AAC.01321-13. Epub 2013 Sep 3. [Article]
  18. Monecke S, Coombs GW, Pearson J, Hotzel H, Slickers P, Ehricht R: A clonal complex 12 methicillin-resistant Staphylococcus aureus strain, West Australian MRSA-59, harbors a novel pseudo-SCCmec element. Antimicrob Agents Chemother. 2015 Nov;59(11):7142-4. doi: 10.1128/AAC.01745-15. Epub 2015 Sep 8. [Article]
  19. Planet PJ, Diaz L, Kolokotronis SO, Narechania A, Reyes J, Xing G, Rincon S, Smith H, Panesso D, Ryan C, Smith DP, Guzman M, Zurita J, Sebra R, Deikus G, Nolan RL, Tenover FC, Weinstock GM, Robinson DA, Arias CA: Parallel Epidemics of Community-Associated Methicillin-Resistant Staphylococcus aureus USA300 Infection in North and South America. J Infect Dis. 2015 Dec 15;212(12):1874-82. doi: 10.1093/infdis/jiv320. Epub 2015 Jun 5. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB04918Ceftobiproleapproved, investigationalyesinhibitorDetails
DB14733Ceftobiprole medocarilapproved, experimental, investigationalyesinhibitorDetails