Serine/threonine-protein kinase TAO1

Details

Name
Serine/threonine-protein kinase TAO1
Synonyms
  • 2.7.11.1
  • hKFC-B
  • hTAOK1
  • KIAA1361
  • Kinase from chicken homolog B
  • MAP3K16
  • MARK Kinase
  • MARKK
  • Prostate-derived STE20-like kinase 2
  • Prostate-derived sterile 20-like kinase 2
  • PSK-2
  • PSK2
  • TAOK1
  • Thousand and one amino acid protein kinase 1
Gene Name
TAOK1
Organism
Humans
Amino acid sequence
>lcl|BSEQ0051662|Serine/threonine-protein kinase TAO1
MPSTNRAGSLKDPEIAELFFKEDPEKLFTDLREIGHGSFGAVYFARDVRTNEVVAIKKMS
YSGKQSTEKWQDIIKEVKFLQRIKHPNSIEYKGCYLREHTAWLVMEYCLGSASDLLEVHK
KPLQEVEIAAITHGALQGLAYLHSHTMIHRDIKAGNILLTEPGQVKLADFGSASMASPAN
SFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQN
ESPTLQSNEWSDYFRNFVDSCLQKIPQDRPTSEELLKHIFVLRERPETVLIDLIQRTKDA
VRELDNLQYRKMKKLLFQEAHNGPAVEAQEEEEEQDHGVGRTGTVNSVGSNQSIPSMSIS
ASSQSSSVNSLPDVSDDKSELDMMEGDHTVMSNSSVIHLKPEEENYREEGDPRTRASDPQ
SPPQVSRHKSHYRNREHFATIRTASLVTRQMQEHEQDSELREQMSGYKRMRRQHQKQLMT
LENKLKAEMDEHRLRLDKDLETQRNNFAAEMEKLIKKHQAAMEKEAKVMSNEEKKFQQHI
QAQQKKELNSFLESQKREYKLRKEQLKEELNENQSTPKKEKQEWLSKQKENIQHFQAEEE
ANLLRRQRQYLELECRRFKRRMLLGRHNLEQDLVREELNKRQTQKDLEHAMLLRQHESMQ
ELEFRHLNTIQKMRCELIRLQHQTELTNQLEYNKRRERELRRKHVMEVRQQPKSLKSKEL
QIKKQFQDTCKIQTRQYKALRNHLLETTPKSEHKAVLKRLKEEQTRKLAILAEQYDHSIN
EMLSTQALRLDEAQEAECQVLKMQLQQELELLNAYQSKIKMQAEAQHDRELRELEQRVSL
RRALLEQKIEEEMLALQNERTERIRSLLERQAREIEAFDSESMRLGFSNMVLSNLSPEAF
SHSYPGASGWSHNPTGGPGPHWGHPMGGPPQAWGHPMQGGPQPWGHPSGPMQGVPRGSSM
GVRNSPQALRRTASGGRTEQGMSRSTSVTSQISNGSHMSYT
Number of residues
1001
Molecular Weight
116069.56
Theoretical pI
Not Available
GO Classification
Functions
ATP binding / kinase activity / MAP kinase kinase kinase activity / protein kinase activity / protein serine/threonine kinase activator activity / protein serine/threonine kinase activity / transferase activity
Processes
activation of JUN kinase activity / activation of MAPK activity / cellular response to DNA damage stimulus / DNA repair / execution phase of apoptosis / mitotic G2 DNA damage checkpoint / nervous system development / positive regulation of JNK cascade / positive regulation of stress-activated MAPK cascade / protein autophosphorylation / protein phosphorylation / regulation of actin cytoskeleton organization / regulation of apoptotic process / regulation of cytoskeleton organization / regulation of microtubule cytoskeleton organization / regulation of mitotic cell cycle / sister chromatid cohesion
Components
cytoplasm / cytosol / extracellular exosome
General Function
Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade.
Specific Function
Atp binding
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0051663|Serine/threonine-protein kinase TAO1 (TAOK1)
ATGCCATCAACTAACAGAGCAGGCAGCCTGAAGGACCCTGAAATTGCAGAGCTCTTCTTC
AAAGAAGATCCAGAGAAGCTCTTCACAGATCTCAGAGAAATTGGCCATGGAAGCTTTGGA
GCAGTGTATTTTGCACGAGATGTGCGTACCAATGAAGTGGTGGCCATCAAGAAAATGTCT
TATAGTGGAAAGCAGTCTACTGAGAAATGGCAGGATATTATTAAGGAAGTCAAGTTTCTA
CAAAGAATAAAACATCCCAACAGTATAGAATACAAAGGCTGTTATTTACGTGAACACACA
GCATGGCTTGTAATGGAATATTGTTTAGGATCTGCTTCGGATTTACTAGAAGTTCACAAA
AAGCCATTACAAGAAGTGGAAATAGCAGCAATTACACATGGTGCTCTTCAGGGATTAGCC
TACTTACATTCTCATACTATGATTCATAGAGATATCAAAGCAGGAAATATCCTTCTGACA
GAACCAGGCCAGGTGAAACTTGCTGACTTTGGCTCTGCTTCCATGGCATCACCTGCCAAT
TCCTTTGTGGGAACGCCGTATTGGATGGCCCCAGAAGTAATTTTAGCCATGGATGAAGGA
CAATATGATGGCAAAGTAGATGTGTGGTCTCTTGGAATAACATGTATTGAACTAGCGGAA
AGGAAGCCTCCTTTATTTAATATGAATGCAATGAGTGCCTTATATCACATAGCCCAAAAT
GAATCCCCTACACTACAGTCTAATGAATGGTCTGATTATTTTCGCAACTTTGTAGATTCT
TGCCTCCAGAAAATCCCTCAAGATCGACCTACATCAGAGGAACTTTTAAAGCACATATTT
GTTCTTCGGGAGCGCCCTGAAACCGTGTTAATAGATCTCATTCAGAGGACAAAGGATGCA
GTAAGAGAGCTGGACAATCTGCAGTATCGAAAGATGAAGAAACTCCTTTTCCAGGAGGCA
CATAATGGACCAGCAGTAGAAGCACAGGAAGAAGAAGAGGAACAAGATCATGGTGTTGGC
CGGACAGGAACAGTTAATAGTGTTGGAAGTAATCAATCCATTCCCAGCATGTCCATCAGT
GCCAGCAGCCAAAGCAGTAGTGTTAACAGTCTTCCAGATGTCTCAGATGACAAGAGTGAG
CTAGACATGATGGAGGGAGACCACACAGTGATGTCTAACAGTTCTGTTATCCATTTAAAA
CCAGAGGAAGAAAATTACAGAGAAGAGGGAGATCCTAGAACAAGAGCATCAGATCCACAA
TCTCCACCCCAAGTATCTCGTCACAAATCACACTATCGTAATCGAGAACACTTTGCTACT
ATACGGACAGCATCACTGGTTACGAGGCAAATGCAAGAACATGAGCAGGACTCTGAGCTT
AGAGAACAAATGTCTGGCTATAAGCGAATGAGGCGACAACATCAAAAGCAACTGATGACT
CTGGAAAACAAGCTAAAGGCTGAGATGGATGAACATCGCCTCAGATTAGACAAAGATCTT
GAAACTCAGCGTAACAATTTTGCTGCAGAAATGGAGAAACTTATCAAGAAACACCAGGCT
GCCATGGAGAAAGAGGCTAAAGTGATGTCCAATGAAGAGAAAAAATTTCAGCAACATATT
CAGGCCCAACAGAAGAAAGAACTGAATAGTTTTCTCGAGTCCCAGAAAAGAGAGTATAAA
CTTCGAAAAGAGCAGCTTAAAGAGGAGCTAAATGAAAACCAGAGTACCCCCAAAAAAGAA
AAACAGGAGTGGCTTTCAAAGCAGAAGGAGAATATACAGCATTTCCAAGCAGAAGAAGAA
GCTAACCTTCTTCGACGTCAAAGACAATACCTAGAGCTGGAATGCCGTCGCTTCAAGAGA
AGAATGTTACTTGGGCGTCATAACTTAGAGCAGGACCTTGTCAGGGAGGAGTTAAACAAA
AGACAGACTCAGAAGGACTTAGAGCATGCCATGCTACTCCGACAGCATGAATCTATGCAA
GAACTGGAGTTCCGCCACCTCAACACAATTCAGAAGATGCGCTGTGAGTTGATCAGATTA
CAGCATCAAACTGAGCTCACTAACCAGCTGGAATATAATAAGCGAAGAGAACGAGAACTA
AGACGAAAGCATGTCATGGAAGTTCGACAACAGCCTAAGAGTTTGAAGTCTAAAGAACTC
CAAATAAAAAAGCAGTTTCAGGATACCTGCAAAATCCAAACCAGACAGTACAAAGCATTA
AGAAATCACCTGCTGGAGACTACACCAAAGAGTGAGCACAAAGCTGTTCTGAAACGGCTC
AAGGAGGAACAGACCCGGAAATTAGCTATCTTGGCTGAGCAGTATGATCACAGCATTAAT
GAAATGCTCTCCACACAAGCCCTGCGTTTGGATGAAGCACAGGAAGCAGAGTGCCAGGTT
TTGAAGATGCAGCTGCAGCAGGAACTGGAGCTGTTGAATGCGTATCAGAGCAAAATCAAG
ATGCAAGCTGAGGCACAACATGATCGAGAGCTTCGCGAGCTTGAACAGAGGGTCTCCCTC
CGGAGGGCACTCTTAGAACAAAAGATTGAAGAAGAGATGTTGGCTTTGCAGAATGAGCGC
ACAGAACGAATACGAAGCCTGTTGGAACGTCAAGCCAGAGAGATTGAAGCTTTTGACTCT
GAAAGCATGAGACTAGGTTTTAGTAATATGGTCCTTTCTAATCTCTCCCCTGAGGCATTC
AGCCACAGCTACCCGGGAGCTTCTGGTTGGTCACACAACCCTACTGGGGGTCCAGGACCT
CACTGGGGTCATCCCATGGGTGGCCCACCACAAGCTTGGGGCCATCCAATGCAAGGTGGA
CCCCAGCCATGGGGTCACCCTTCAGGGCCAATGCAAGGGGTACCTCGAGGTAGCAGTATG
GGAGTCCGCAATAGCCCCCAGGCTCTGAGGCGGACAGCTTCTGGGGGACGGACGGAGCAG
GGCATGAGCAGAAGCACGAGTGTCACTTCACAAATATCCAATGGGTCACACATGTCTTAT
ACATAA
Chromosome Location
17
Locus
17q11.2
External Identifiers
ResourceLink
UniProtKB IDQ7L7X3
UniProtKB Entry NameTAOK1_HUMAN
HGNC IDHGNC:29259
General References
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  2. Nagase T, Kikuno R, Ishikawa KI, Hirosawa M, Ohara O: Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 2000 Feb 28;7(1):65-73. [Article]
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  9. Huangfu WC, Omori E, Akira S, Matsumoto K, Ninomiya-Tsuji J: Osmotic stress activates the TAK1-JNK pathway while blocking TAK1-mediated NF-kappaB activation: TAO2 regulates TAK1 pathways. J Biol Chem. 2006 Sep 29;281(39):28802-10. Epub 2006 Aug 7. [Article]
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB12010Fostamatinibapproved, investigationalunknowninhibitorDetails