Ribonucleoside-diphosphate reductase subunit M2 B
Details
- Name
- Ribonucleoside-diphosphate reductase subunit M2 B
- Synonyms
- 1.17.4.1
- p53-inducible ribonucleotide reductase small subunit 2-like protein
- P53R2
- TP53-inducible ribonucleotide reductase M2 B
- Gene Name
- RRM2B
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0006951|Ribonucleoside-diphosphate reductase subunit M2 B MGDPERPEAAGLDQDERSSSDTNESEIKSNEEPLLRKSSRRFVIFPIQYPDIWKMYKQAQ ASFWTAEEVDLSKDLPHWNKLKADEKYFISHILAFFAASDGIVNENLVERFSQEVQVPEA RCFYGFQILIENVHSEMYSLLIDTYIRDPKKREFLFNAIETMPYVKKKADWALRWIADRK STFGERVVAFAAVEGVFFSGSFAAIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFQ YLVNKPSEERVREIIVDAVKIEQEFLTEALPVGLIGMNCILMKQYIEFVADRLLVELGFS KVFQAENPFDFMENISLEGKTNFFEKRVSEYQRFAVMAETTDNVFTLDADF
- Number of residues
- 351
- Molecular Weight
- 40736.11
- Theoretical pI
- 4.61
- GO Classification
- Functionsmetal ion binding / ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptorProcessesdeoxyribonucleoside diphosphate metabolic process / deoxyribonucleoside triphosphate metabolic process / deoxyribonucleotide biosynthetic process / DNA repair / gene expression / kidney development / mitochondrial DNA replication / negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator / nucleobase-containing small molecule interconversion / nucleobase-containing small molecule metabolic process / renal system process / response to oxidative stress / small molecule metabolic process / transcription initiation from RNA polymerase II promoterComponentscytoplasm / cytosol / extracellular exosome / mitochondrion / nucleoplasm / ribonucleoside-diphosphate reductase complex
- General Function
- Ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
- Specific Function
- Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage.
- Pfam Domain Function
- Ribonuc_red_sm (PF00268)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0021362|Ribonucleoside-diphosphate reductase subunit M2 B (RRM2B) ATGTTGCTGTTGCGTCTTCCCCCTCACCGCAGTCACGCCAGCCCGTTAGATTGCAAGTTG CAGGACCGCTGTAGGAAATGTTATTCGCCGCGGTCAGGACAGGCCTGTCCGCCCGCCCTC GCCGCAGCCTGGCTTCGTCGTTGCGAGCGCCGGGGAGGCCGTCCCCGGGGAGGGCGGAGG AAGGAGCTGACTTTGGGTTTGCGTCCCGCTCGCTGCTCTGCCCCGGGGCCAGCCAAGGAC GACGCTTGGAGGCCTCAGGCCGGGAGATCATCTTCAGACACCAACGAAAGTGAAATAAAG TCAAATGAAGAGCCACTCCTAAGAAAGAGTTCTCGCCGGTTTGTCATCTTTCCAATCCAG TACCCTGATATTTGGAAAATGTATAAACAGGCACAGGCTTCCTTCTGGACAGCAGAAGAG GTCGACTTATCAAAGGATCTCCCTCACTGGAACAAGCTTAAAGCAGATGAGAAGTACTTC ATCTCTCACATCTTAGCCTTTTTTGCAGCCAGTGATGGAATTGTAAATGAAAATTTGGTG GAGCGCTTTAGTCAGGAGGTGCAGGTTCCAGAGGCTCGCTGTTTCTATGGCTTTCAAATT CTCATCGAGAATGTTCACTCAGAGATGTACAGTTTGCTGATAGACACTTACATCAGAGAT CCCAAGAAAAGGGAATTTTTATTTAATGCAATTGAAACCATGCCCTATGTTAAGAAAAAA GCAGATTGGGCCTTGCGATGGATAGCAGATAGAAAATCTACTTTTGGGGAAAGAGTGGTG GCCTTTGCTGCTGTAGAAGGAGTTTTCTTCTCAGGATCTTTTGCTGCTATATTCTGGCTA AAGAAGAGAGGTCTTATGCCAGGACTCACTTTTTCCAATGAACTCATCAGCAGAGATGAA GGACTTCACTGTGACTTTGCTTGCCTGATGTTCCAATACTTAGTAAATAAGCCTTCAGAA GAAAGGGTCAGGGAGATCATTGTTGATGCTGTCAAAATTGAGCAGGAGTTTTTAACAGAA GCCTTGCCAGTTGGCCTCATTGGAATGAATTGCATTTTGATGAAACAGTACATTGAGTTT GTAGCTGACAGATTACTTGTGGAACTTGGATTCTCAAAGGTTTTTCAGGCAGAAAATCCT TTTGATTTTATGGAAAACATTTCTTTAGAAGGAAAAACAAATTTCTTTGAGAAACGAGTT TCAGAGTATCAGCGTTTTGCAGTTATGGCAGAAACCACAGATAACGTCTTCACCTTGGAT GCAGATTTTTAA
- Chromosome Location
- 8
- Locus
- 8q23.1
- External Identifiers
Resource Link UniProtKB ID Q7LG56 UniProtKB Entry Name RIR2B_HUMAN GenBank Protein ID 7229086 GenBank Gene ID AB036063 HGNC ID HGNC:17296 - General References
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