Polycystic kidney disease protein 1-like 3
Details
- Name
- Polycystic kidney disease protein 1-like 3
- Synonyms
- PC1-like 3 protein
- Polycystin-1L3
- Gene Name
- PKD1L3
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0049529|Polycystic kidney disease protein 1-like 3 MFFKGGSWLWLYIRTSIILGSELNSPAPHGQNNCYQLNRFQCSFEEAQHYCHVQRGFLAH IWNKEVQDLIRDYLEEGKKWWIGQNVMPLKKHQDNKYPADVAANGPPKPLSCTYLSRNFI RISSKGDKCLLKYYFICQTGDFLDGDAHYERNGNNSHLYQRHKKTKRGVAIARDKMPPGP GHLPTTCHYPLPAHLSKTLCHPISQFPSVLSSITSQVTSAASEPSSQPLPVITQLTMPVS VTHAGQSLAETTSSPKEEGHPNTFTSYLQVSLQKASGQVIDEIAGNFSRAVHGLQALNKL QEACEFLQKLTALTPRFSKPAQVNLINSLIYLSEELLRIPFQNNNSLGFKVPPTVCPFHS LNNVTKAGEGSWLESKRHTEPVEDILEMSLVEFGNIGEAFLEQNQSPESSVTLTSANATL LLSRQNISTLPLSSYTLGHPAPVRLGFPSALALKELLNKHPGVNVQITGLAFNPFKDLDN RNIVGSIGSVLLSANRKLLQVHDLMEDIEIMLWRNVSLETHPTSLNMSTHQLTITVNVTS LEKSLIVSIDPDSPLLMTLYLGFQYQPNCTHFHLNITLPKDKVWQKDEEYTWVLNPEHLQ HGIGTYYITAVLSERQEGAQQTPSLVSVITAVTQCYYWEIHNQTWSSAGCQVGPQSTILR TQCLCNHLTFFASDFFVVPRTVNVEDTIKLFLRVTNNPVGVSLLASLLGFYVITVVWARK KDQADMQKVKVTVLADNDPSAQFHYLIQVYTGYRRSAATTAKVVITLYGSEGRSEPHHLC DPQKTVFERGGLDVFLLTTWTSLGNLHSLRLWHDNSGVSPSWYVSQVIVCDMAVKRKWHF LCNCWLAVDLGDCELDRVFIPVSKRELFSFRHLFSSMIVEKFTQDYLWLSIATRHPWNQF TRVQRLSCCMTLLLCNMVINVMFWKINSTTAKRDEQMRPFAVAWSELLVSIHTAVILFPI NLVIGRLFPLIEPQETLPLFPPIQASCLSDASVEPLSATMVVEELKETVRFLLRRNTYLL SKCEQPPWSSWDITKLVKLLSSLVSSHLEGQGCHQQGERHWARVVPENHHHFCCYLHRVL QRLKSHLGTLGLTQGHQSCDFLDAASQLQKLQELLETHILPTEQEPSREVTSFAILSSEE GKKPISNGLSKWLTSVCWLLLGFTSLASAFFTALYSLELSKDQATSWMISIILSVLQNIF ISQPVKVVFFTFLYSLMMSRMPRLNKENEQQTKRILALLAKCSSSVPGSRDKNNPVYVAP AINSPTKHPERTLKKKKLFKLTGDILVQILFLTLLMTAIYSAKNSNRFYLHQAIWKTFSH QFSEIKLLQDFYPWANHILLPSLYGDYRGKNAVLEPSHCKCGVQLIFQIPRTKTYEKVDE GQLAFCDNGHTCGRPKSLFPGLHLRRFSYICSPRPMVLIPTDELHERLTSKNENGFSYIM RGAFFTSLRLESFTSLQMSKKGCVWSIISQVIYYLLVCYYAFIQGCQLKQQKWRFFTGKR NILDTSIILISFILLGLDMKSISLHKKNMARYRDDQDRFISFYEAVKVNSAATHLVGFPV LLATVQLWNLLRHSPRLRVISRTLSRAWDEVVGFLLIILILLTGYAIAFNLLFGCSISDY RTFFSSAVTVVGLLMGISHQEEVFALDPVLGTFLILTSVILMVLVVINLFVSAILMAFGK ERKSLKKEAALIDTLLQKLSNLLGISWPQKTSSEQAATTAVGSDTEVLDELP
- Number of residues
- 1732
- Molecular Weight
- 195891.885
- Theoretical pI
- Not Available
- GO Classification
- Functionscalcium channel activity / carbohydrate bindingProcessescation transport / cellular response to acidic pH / detection of chemical stimulus involved in sensory perception of sour taste / detection of mechanical stimulus / kidney development / sensory perception of sour tasteComponentscation channel complex / cell surface / extracellular exosome / plasma membrane / receptor complex
- General Function
- Component of a calcium channel. May act as a sour taste receptor by forming a calcium channel with PKD1L3 in gustatory cells; however, its contribution to sour taste perception is unclear in vivo and may be indirect.
- Specific Function
- Calcium channel activity
- Pfam Domain Function
- Transmembrane Regions
- 698-718 906-926 940-960 1155-1175 1199-1219 1281-1301 1463-1483 1502-1522 1551-1571 1593-1613 1626-1646 1659-1679
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0049530|Polycystic kidney disease protein 1-like 3 (PKD1L3) ATGTTCTTCAAAGGAGGAAGCTGGCTTTGGTTATACATCAGAACAAGTATTATTCTAGGA AGTGAGCTAAACAGCCCAGCACCACATGGGCAAAATAATTGTTACCAGCTTAACAGATTT CAATGCAGCTTTGAGGAAGCACAGCATTACTGTCATGTGCAGAGAGGATTCCTAGCTCAT ATTTGGAACAAGGAAGTTCAAGATCTCATCCGGGACTATCTGGAAGAAGGAAAGAAGTGG TGGATTGGGCAAAATGTAATGCCATTGAAAAAGCATCAAGACAACAAATACCCAGCAGAC GTTGCAGCCAACGGGCCCCCAAAGCCCCTCAGCTGCACCTACCTGTCCAGAAACTTCATT CGGATCTCATCCAAAGGGGACAAGTGCTTACTGAAATACTATTTCATTTGCCAGACTGGT GACTTTTTGGACGGAGATGCCCATTATGAAAGAAATGGAAATAATTCCCATTTGTACCAG AGACACAAGAAGACAAAAAGAGGAGTTGCAATAGCAAGAGACAAAATGCCCCCAGGACCT GGTCATCTTCCAACCACATGTCACTATCCTCTTCCTGCTCATCTTTCCAAGACCCTGTGT CATCCCATCAGCCAGTTTCCTTCAGTACTATCAAGTATCACATCACAGGTAACATCAGCC GCATCTGAACCCAGCAGCCAGCCTCTCCCTGTGATAACACAGCTCACCATGCCCGTGTCT GTCACGCATGCTGGGCAATCTCTGGCAGAAACAACTTCAAGCCCAAAGGAAGAAGGTCAT CCGAATACCTTCACCTCTTATCTACAAGTGTCATTGCAGAAGGCATCTGGTCAGGTCATA GATGAGATAGCAGGGAACTTCAGCAGAGCAGTTCATGGTTTGCAAGCTCTTAACAAACTA CAGGAAGCTTGTGAGTTCCTCCAGAAACTAACAGCCTTAACCCCAAGATTTTCTAAGCCA GCTCAGGTTAATCTCATCAATTCCCTTATTTACCTGAGTGAGGAGTTACTCAGGATCCCA TTTCAGAACAACAACAGTCTGGGCTTCAAAGTTCCTCCAACTGTCTGCCCCTTTCATTCC CTCAACAATGTCACCAAAGCTGGAGAAGGAAGTTGGCTGGAATCCAAGCGTCATACTGAG CCGGTAGAAGACATCCTGGAAATGTCCTTGGTGGAGTTTGGGAATATCGGGGAAGCATTT CTAGAGCAGAACCAGTCTCCCGAGTCTTCAGTGACTTTGACCTCTGCCAATGCTACTCTG CTGCTGAGCAGACAAAACATATCAACTTTACCGCTGAGCTCTTACACTCTGGGTCACCCA GCCCCTGTGAGGCTAGGCTTTCCGTCGGCTTTAGCTTTGAAGGAGCTCTTGAATAAACAT CCAGGAGTTAATGTCCAAATAACAGGACTAGCTTTCAATCCCTTCAAGGATTTGGACAAC AGAAACATTGTTGGAAGCATTGGAAGTGTGTTACTAAGCGCTAATCGTAAATTGCTCCAA GTCCATGATTTAATGGAGGACATTGAGATCATGCTCTGGAGAAATGTTAGCTTGGAAACC CATCCCACCAGCCTCAACATGAGCACACATCAGCTTACAATCACAGTGAACGTCACTTCC TTGGAGAAATCCTTGATAGTGAGCATAGATCCTGACAGTCCCCTTTTAATGACACTCTAC CTGGGGTTCCAGTATCAGCCTAACTGCACTCACTTCCACCTGAACATCACCCTTCCAAAG GATAAGGTGTGGCAAAAAGATGAGGAGTACACGTGGGTGCTGAATCCAGAGCATCTGCAG CACGGGATTGGCACCTACTATATAACAGCTGTGCTGAGTGAGAGGCAGGAGGGTGCTCAG CAGACACCCAGCTTGGTCTCGGTCATCACCGCCGTCACTCAGTGTTACTACTGGGAGATC CACAACCAGACATGGAGCAGCGCCGGATGCCAAGTTGGGCCACAGAGCACAATTCTGAGG ACACAGTGTCTCTGTAACCACCTGACCTTCTTTGCCAGCGACTTCTTTGTCGTGCCCAGG ACCGTGAATGTTGAAGACACGATCAAACTGTTCCTTCGCGTGACCAACAATCCTGTTGGG GTGTCACTGCTGGCCAGCCTTTTAGGATTTTATGTGATCACAGTTGTGTGGGCTCGGAAA AAGGATCAAGCAGATATGCAGAAGGTGAAGGTCACTGTCCTGGCTGATAATGACCCCAGC GCTCAATTTCACTACCTTATTCAGGTCTACACCGGATATCGAAGAAGCGCTGCTACAACA GCTAAGGTTGTCATCACCCTCTATGGATCAGAGGGACGGAGTGAGCCCCATCACCTCTGT GACCCCCAGAAGACAGTCTTTGAACGAGGGGGCCTGGATGTCTTCCTTCTCACCACTTGG ACCTCTCTAGGGAACCTGCACAGCCTTCGGCTCTGGCATGACAATTCTGGCGTCAGTCCC TCCTGGTATGTCAGCCAGGTAATTGTCTGTGACATGGCAGTTAAGAGGAAGTGGCATTTC CTGTGCAATTGCTGGCTGGCTGTGGACCTCGGAGACTGTGAGCTTGACCGGGTCTTCATC CCAGTTTCAAAGAGAGAGCTCTTTTCCTTTAGACATCTGTTTTCCTCCATGATTGTGGAA AAGTTCACCCAGGATTATCTGTGGCTTTCAATTGCAACTCGGCATCCCTGGAACCAGTTT ACAAGGGTCCAACGGCTGTCTTGCTGCATGACACTGCTACTCTGCAACATGGTCATCAAT GTTATGTTCTGGAAGATAAACAGCACCACTGCCAAGAGAGATGAGCAAATGCGTCCATTT GCTGTGGCCTGGTCTGAACTGCTGGTCAGCATCCATACTGCTGTCATCCTCTTCCCAATC AATCTTGTCATAGGGCGGCTCTTCCCGTTGATTGAGCCACAGGAGACTCTGCCCCTCTTT CCTCCCATCCAGGCCTCCTGCCTCTCAGATGCTTCTGTTGAGCCTCTCTCTGCCACAATG GTAGTTGAGGAATTAAAGGAAACTGTGAGATTCCTGCTCAGGAGAAATACATACCTACTC TCCAAGTGTGAGCAGCCGCCATGGAGTTCTTGGGACATTACTAAGCTGGTGAAACTTTTA TCCAGCCTCGTATCATCTCACTTGGAGGGTCAAGGCTGTCATCAGCAGGGAGAGCGCCAC TGGGCACGTGTTGTTCCTGAAAACCACCATCATTTCTGCTGTTACCTGCATAGAGTTCTG CAGAGGCTGAAATCTCACTTAGGCACGCTGGGTCTCACCCAGGGTCACCAGTCCTGTGAC TTCCTAGATGCAGCCAGCCAACTTCAAAAACTCCAGGAACTCTTGGAAACACATATTCTT CCCACGGAGCAAGAGCCATCCAGGGAAGTCACCAGTTTTGCCATCCTGAGCTCAGAAGAA GGAAAAAAGCCCATCTCAAATGGCCTGTCCAAATGGTTGACTTCAGTCTGCTGGCTCCTC TTAGGTTTCACTAGCCTGGCTTCAGCCTTTTTTACAGCACTTTATAGCTTGGAATTGAGC AAAGACCAAGCCACCAGCTGGATGATTTCAATTATTTTATCAGTGCTTCAGAACATCTTC ATCAGCCAGCCAGTAAAGGTGGTCTTCTTCACATTCTTATACTCACTGATGATGAGCAGG ATGCCACGGCTTAACAAAGAGAATGAACAACAAACAAAGAGGATCTTGGCACTCTTGGCA AAATGTTCTTCGTCAGTACCAGGTTCAAGAGATAAGAACAACCCCGTCTATGTAGCCCCA GCTATAAATAGTCCAACTAAGCACCCAGAAAGAACCTTGAAAAAGAAGAAACTCTTCAAG CTGACTGGAGATATTTTGGTACAAATCCTCTTCCTTACCCTGTTGATGACTGCAATCTAC TCTGCAAAGAACTCCAATAGATTTTACCTCCACCAAGCTATCTGGAAGACATTTTCGCAC CAGTTCTCGGAAATCAAACTTCTTCAGGATTTCTACCCCTGGGCCAATCATATCCTTCTT CCTAGCCTGTATGGGGATTACAGAGGTAAGAATGCAGTCCTGGAGCCCAGTCATTGCAAA TGTGGGGTACAATTAATTTTCCAAATACCCCGTACCAAGACCTATGAGAAAGTGGACGAA GGTCAGCTGGCGTTTTGTGATAACGGCCATACCTGTGGGCGTCCCAAGAGCCTATTCCCT GGACTTCATCTAAGGAGGTTCAGTTACATCTGTTCACCCAGGCCCATGGTGCTGATTCCC ACTGATGAGCTTCACGAAAGGCTGACAAGCAAGAATGAGAATGGATTCAGTTACATCATG AGAGGTGCTTTCTTCACCTCTTTGAGACTGGAAAGCTTCACTTCCCTTCAGATGTCAAAG AAGGGCTGTGTCTGGTCTATCATCTCACAAGTCATCTATTATCTACTGGTCTGTTACTAT GCCTTCATACAGGGTTGTCAGCTGAAACAGCAGAAGTGGAGGTTCTTCACTGGGAAAAGA AACATTCTGGACACAAGTATAATCCTCATTAGCTTCATCCTCCTGGGGCTTGACATGAAG AGTATTTCTCTACATAAGAAAAACATGGCACGATACCGCGATGACCAGGACAGATTCATC AGCTTCTATGAGGCAGTAAAAGTGAACTCTGCTGCGACTCACCTTGTGGGCTTCCCGGTT CTCCTGGCAACTGTTCAGTTATGGAACCTGCTGCGTCATAGCCCCAGGCTGCGGGTCATC AGCAGGACACTGAGCCGAGCCTGGGACGAGGTGGTGGGCTTTCTGCTGATCATCCTAATC CTGCTGACAGGCTATGCCATTGCCTTTAACCTGCTGTTTGGATGCAGCATCTCTGACTAC CGGACATTTTTCAGCTCAGCAGTGACTGTTGTTGGTCTCCTGATGGGAATTTCTCACCAA GAGGAGGTTTTCGCTTTAGACCCAGTCCTGGGCACCTTTCTGATCCTCACCAGTGTCATC TTGATGGTACTTGTGGTAATTAATCTTTTCGTTTCGGCCATTCTCATGGCCTTTGGAAAA GAAAGAAAGTCGCTTAAGAAAGAAGCTGCACTAATAGATACACTGCTACAGAAGCTCTCA AATTTGTTAGGAATCAGTTGGCCCCAAAAAACCTCATCTGAGCAAGCAGCCACGACAGCA GTGGGCAGTGACACTGAAGTTTTAGATGAACTACCTTAA
- Chromosome Location
- 16
- Locus
- 16q22.2
- External Identifiers
Resource Link UniProtKB ID Q7Z443 UniProtKB Entry Name PK1L3_HUMAN HGNC ID HGNC:21716 - General References
- Li A, Tian X, Sung SW, Somlo S: Identification of two novel polycystic kidney disease-1-like genes in human and mouse genomes. Genomics. 2003 Jun;81(6):596-608. [Article]
- Inada H, Kawabata F, Ishimaru Y, Fushiki T, Matsunami H, Tominaga M: Off-response property of an acid-activated cation channel complex PKD1L3-PKD2L1. EMBO Rep. 2008 Jul;9(7):690-7. doi: 10.1038/embor.2008.89. Epub 2008 Jun 6. [Article]
- Ishii S, Misaka T, Kishi M, Kaga T, Ishimaru Y, Abe K: Acetic acid activates PKD1L3-PKD2L1 channel--a candidate sour taste receptor. Biochem Biophys Res Commun. 2009 Jul 31;385(3):346-50. doi: 10.1016/j.bbrc.2009.05.069. Epub 2009 May 21. [Article]
- Huque T, Cowart BJ, Dankulich-Nagrudny L, Pribitkin EA, Bayley DL, Spielman AI, Feldman RS, Mackler SA, Brand JG: Sour ageusia in two individuals implicates ion channels of the ASIC and PKD families in human sour taste perception at the anterior tongue. PLoS One. 2009 Oct 8;4(10):e7347. doi: 10.1371/journal.pone.0007347. [Article]
- Ishimaru Y, Katano Y, Yamamoto K, Akiba M, Misaka T, Roberts RW, Asakura T, Matsunami H, Abe K: Interaction between PKD1L3 and PKD2L1 through their transmembrane domains is required for localization of PKD2L1 at taste pores in taste cells of circumvallate and foliate papillae. FASEB J. 2010 Oct;24(10):4058-67. doi: 10.1096/fj.10-162925. Epub 2010 Jun 10. [Article]
- Ishii S, Kurokawa A, Kishi M, Yamagami K, Okada S, Ishimaru Y, Misaka T: The response of PKD1L3/PKD2L1 to acid stimuli is inhibited by capsaicin and its pungent analogs. FEBS J. 2012 May;279(10):1857-70. doi: 10.1111/j.1742-4658.2012.08566.x. Epub 2012 Apr 16. [Article]
- Yu Y, Ulbrich MH, Li MH, Dobbins S, Zhang WK, Tong L, Isacoff EY, Yang J: Molecular mechanism of the assembly of an acid-sensing receptor ion channel complex. Nat Commun. 2012;3:1252. doi: 10.1038/ncomms2257. [Article]