Polycystic kidney disease protein 1-like 3

Details

Name
Polycystic kidney disease protein 1-like 3
Synonyms
  • PC1-like 3 protein
  • Polycystin-1L3
Gene Name
PKD1L3
Organism
Humans
Amino acid sequence
>lcl|BSEQ0049529|Polycystic kidney disease protein 1-like 3
MFFKGGSWLWLYIRTSIILGSELNSPAPHGQNNCYQLNRFQCSFEEAQHYCHVQRGFLAH
IWNKEVQDLIRDYLEEGKKWWIGQNVMPLKKHQDNKYPADVAANGPPKPLSCTYLSRNFI
RISSKGDKCLLKYYFICQTGDFLDGDAHYERNGNNSHLYQRHKKTKRGVAIARDKMPPGP
GHLPTTCHYPLPAHLSKTLCHPISQFPSVLSSITSQVTSAASEPSSQPLPVITQLTMPVS
VTHAGQSLAETTSSPKEEGHPNTFTSYLQVSLQKASGQVIDEIAGNFSRAVHGLQALNKL
QEACEFLQKLTALTPRFSKPAQVNLINSLIYLSEELLRIPFQNNNSLGFKVPPTVCPFHS
LNNVTKAGEGSWLESKRHTEPVEDILEMSLVEFGNIGEAFLEQNQSPESSVTLTSANATL
LLSRQNISTLPLSSYTLGHPAPVRLGFPSALALKELLNKHPGVNVQITGLAFNPFKDLDN
RNIVGSIGSVLLSANRKLLQVHDLMEDIEIMLWRNVSLETHPTSLNMSTHQLTITVNVTS
LEKSLIVSIDPDSPLLMTLYLGFQYQPNCTHFHLNITLPKDKVWQKDEEYTWVLNPEHLQ
HGIGTYYITAVLSERQEGAQQTPSLVSVITAVTQCYYWEIHNQTWSSAGCQVGPQSTILR
TQCLCNHLTFFASDFFVVPRTVNVEDTIKLFLRVTNNPVGVSLLASLLGFYVITVVWARK
KDQADMQKVKVTVLADNDPSAQFHYLIQVYTGYRRSAATTAKVVITLYGSEGRSEPHHLC
DPQKTVFERGGLDVFLLTTWTSLGNLHSLRLWHDNSGVSPSWYVSQVIVCDMAVKRKWHF
LCNCWLAVDLGDCELDRVFIPVSKRELFSFRHLFSSMIVEKFTQDYLWLSIATRHPWNQF
TRVQRLSCCMTLLLCNMVINVMFWKINSTTAKRDEQMRPFAVAWSELLVSIHTAVILFPI
NLVIGRLFPLIEPQETLPLFPPIQASCLSDASVEPLSATMVVEELKETVRFLLRRNTYLL
SKCEQPPWSSWDITKLVKLLSSLVSSHLEGQGCHQQGERHWARVVPENHHHFCCYLHRVL
QRLKSHLGTLGLTQGHQSCDFLDAASQLQKLQELLETHILPTEQEPSREVTSFAILSSEE
GKKPISNGLSKWLTSVCWLLLGFTSLASAFFTALYSLELSKDQATSWMISIILSVLQNIF
ISQPVKVVFFTFLYSLMMSRMPRLNKENEQQTKRILALLAKCSSSVPGSRDKNNPVYVAP
AINSPTKHPERTLKKKKLFKLTGDILVQILFLTLLMTAIYSAKNSNRFYLHQAIWKTFSH
QFSEIKLLQDFYPWANHILLPSLYGDYRGKNAVLEPSHCKCGVQLIFQIPRTKTYEKVDE
GQLAFCDNGHTCGRPKSLFPGLHLRRFSYICSPRPMVLIPTDELHERLTSKNENGFSYIM
RGAFFTSLRLESFTSLQMSKKGCVWSIISQVIYYLLVCYYAFIQGCQLKQQKWRFFTGKR
NILDTSIILISFILLGLDMKSISLHKKNMARYRDDQDRFISFYEAVKVNSAATHLVGFPV
LLATVQLWNLLRHSPRLRVISRTLSRAWDEVVGFLLIILILLTGYAIAFNLLFGCSISDY
RTFFSSAVTVVGLLMGISHQEEVFALDPVLGTFLILTSVILMVLVVINLFVSAILMAFGK
ERKSLKKEAALIDTLLQKLSNLLGISWPQKTSSEQAATTAVGSDTEVLDELP
Number of residues
1732
Molecular Weight
195891.885
Theoretical pI
Not Available
GO Classification
Functions
calcium channel activity / carbohydrate binding
Processes
cation transport / cellular response to acidic pH / detection of chemical stimulus involved in sensory perception of sour taste / detection of mechanical stimulus / kidney development / sensory perception of sour taste
Components
cation channel complex / cell surface / extracellular exosome / plasma membrane / receptor complex
General Function
Component of a calcium channel. May act as a sour taste receptor by forming a calcium channel with PKD1L3 in gustatory cells; however, its contribution to sour taste perception is unclear in vivo and may be indirect.
Specific Function
Calcium channel activity
Pfam Domain Function
Transmembrane Regions
698-718 906-926 940-960 1155-1175 1199-1219 1281-1301 1463-1483 1502-1522 1551-1571 1593-1613 1626-1646 1659-1679
Cellular Location
Cell membrane
Gene sequence
>lcl|BSEQ0049530|Polycystic kidney disease protein 1-like 3 (PKD1L3)
ATGTTCTTCAAAGGAGGAAGCTGGCTTTGGTTATACATCAGAACAAGTATTATTCTAGGA
AGTGAGCTAAACAGCCCAGCACCACATGGGCAAAATAATTGTTACCAGCTTAACAGATTT
CAATGCAGCTTTGAGGAAGCACAGCATTACTGTCATGTGCAGAGAGGATTCCTAGCTCAT
ATTTGGAACAAGGAAGTTCAAGATCTCATCCGGGACTATCTGGAAGAAGGAAAGAAGTGG
TGGATTGGGCAAAATGTAATGCCATTGAAAAAGCATCAAGACAACAAATACCCAGCAGAC
GTTGCAGCCAACGGGCCCCCAAAGCCCCTCAGCTGCACCTACCTGTCCAGAAACTTCATT
CGGATCTCATCCAAAGGGGACAAGTGCTTACTGAAATACTATTTCATTTGCCAGACTGGT
GACTTTTTGGACGGAGATGCCCATTATGAAAGAAATGGAAATAATTCCCATTTGTACCAG
AGACACAAGAAGACAAAAAGAGGAGTTGCAATAGCAAGAGACAAAATGCCCCCAGGACCT
GGTCATCTTCCAACCACATGTCACTATCCTCTTCCTGCTCATCTTTCCAAGACCCTGTGT
CATCCCATCAGCCAGTTTCCTTCAGTACTATCAAGTATCACATCACAGGTAACATCAGCC
GCATCTGAACCCAGCAGCCAGCCTCTCCCTGTGATAACACAGCTCACCATGCCCGTGTCT
GTCACGCATGCTGGGCAATCTCTGGCAGAAACAACTTCAAGCCCAAAGGAAGAAGGTCAT
CCGAATACCTTCACCTCTTATCTACAAGTGTCATTGCAGAAGGCATCTGGTCAGGTCATA
GATGAGATAGCAGGGAACTTCAGCAGAGCAGTTCATGGTTTGCAAGCTCTTAACAAACTA
CAGGAAGCTTGTGAGTTCCTCCAGAAACTAACAGCCTTAACCCCAAGATTTTCTAAGCCA
GCTCAGGTTAATCTCATCAATTCCCTTATTTACCTGAGTGAGGAGTTACTCAGGATCCCA
TTTCAGAACAACAACAGTCTGGGCTTCAAAGTTCCTCCAACTGTCTGCCCCTTTCATTCC
CTCAACAATGTCACCAAAGCTGGAGAAGGAAGTTGGCTGGAATCCAAGCGTCATACTGAG
CCGGTAGAAGACATCCTGGAAATGTCCTTGGTGGAGTTTGGGAATATCGGGGAAGCATTT
CTAGAGCAGAACCAGTCTCCCGAGTCTTCAGTGACTTTGACCTCTGCCAATGCTACTCTG
CTGCTGAGCAGACAAAACATATCAACTTTACCGCTGAGCTCTTACACTCTGGGTCACCCA
GCCCCTGTGAGGCTAGGCTTTCCGTCGGCTTTAGCTTTGAAGGAGCTCTTGAATAAACAT
CCAGGAGTTAATGTCCAAATAACAGGACTAGCTTTCAATCCCTTCAAGGATTTGGACAAC
AGAAACATTGTTGGAAGCATTGGAAGTGTGTTACTAAGCGCTAATCGTAAATTGCTCCAA
GTCCATGATTTAATGGAGGACATTGAGATCATGCTCTGGAGAAATGTTAGCTTGGAAACC
CATCCCACCAGCCTCAACATGAGCACACATCAGCTTACAATCACAGTGAACGTCACTTCC
TTGGAGAAATCCTTGATAGTGAGCATAGATCCTGACAGTCCCCTTTTAATGACACTCTAC
CTGGGGTTCCAGTATCAGCCTAACTGCACTCACTTCCACCTGAACATCACCCTTCCAAAG
GATAAGGTGTGGCAAAAAGATGAGGAGTACACGTGGGTGCTGAATCCAGAGCATCTGCAG
CACGGGATTGGCACCTACTATATAACAGCTGTGCTGAGTGAGAGGCAGGAGGGTGCTCAG
CAGACACCCAGCTTGGTCTCGGTCATCACCGCCGTCACTCAGTGTTACTACTGGGAGATC
CACAACCAGACATGGAGCAGCGCCGGATGCCAAGTTGGGCCACAGAGCACAATTCTGAGG
ACACAGTGTCTCTGTAACCACCTGACCTTCTTTGCCAGCGACTTCTTTGTCGTGCCCAGG
ACCGTGAATGTTGAAGACACGATCAAACTGTTCCTTCGCGTGACCAACAATCCTGTTGGG
GTGTCACTGCTGGCCAGCCTTTTAGGATTTTATGTGATCACAGTTGTGTGGGCTCGGAAA
AAGGATCAAGCAGATATGCAGAAGGTGAAGGTCACTGTCCTGGCTGATAATGACCCCAGC
GCTCAATTTCACTACCTTATTCAGGTCTACACCGGATATCGAAGAAGCGCTGCTACAACA
GCTAAGGTTGTCATCACCCTCTATGGATCAGAGGGACGGAGTGAGCCCCATCACCTCTGT
GACCCCCAGAAGACAGTCTTTGAACGAGGGGGCCTGGATGTCTTCCTTCTCACCACTTGG
ACCTCTCTAGGGAACCTGCACAGCCTTCGGCTCTGGCATGACAATTCTGGCGTCAGTCCC
TCCTGGTATGTCAGCCAGGTAATTGTCTGTGACATGGCAGTTAAGAGGAAGTGGCATTTC
CTGTGCAATTGCTGGCTGGCTGTGGACCTCGGAGACTGTGAGCTTGACCGGGTCTTCATC
CCAGTTTCAAAGAGAGAGCTCTTTTCCTTTAGACATCTGTTTTCCTCCATGATTGTGGAA
AAGTTCACCCAGGATTATCTGTGGCTTTCAATTGCAACTCGGCATCCCTGGAACCAGTTT
ACAAGGGTCCAACGGCTGTCTTGCTGCATGACACTGCTACTCTGCAACATGGTCATCAAT
GTTATGTTCTGGAAGATAAACAGCACCACTGCCAAGAGAGATGAGCAAATGCGTCCATTT
GCTGTGGCCTGGTCTGAACTGCTGGTCAGCATCCATACTGCTGTCATCCTCTTCCCAATC
AATCTTGTCATAGGGCGGCTCTTCCCGTTGATTGAGCCACAGGAGACTCTGCCCCTCTTT
CCTCCCATCCAGGCCTCCTGCCTCTCAGATGCTTCTGTTGAGCCTCTCTCTGCCACAATG
GTAGTTGAGGAATTAAAGGAAACTGTGAGATTCCTGCTCAGGAGAAATACATACCTACTC
TCCAAGTGTGAGCAGCCGCCATGGAGTTCTTGGGACATTACTAAGCTGGTGAAACTTTTA
TCCAGCCTCGTATCATCTCACTTGGAGGGTCAAGGCTGTCATCAGCAGGGAGAGCGCCAC
TGGGCACGTGTTGTTCCTGAAAACCACCATCATTTCTGCTGTTACCTGCATAGAGTTCTG
CAGAGGCTGAAATCTCACTTAGGCACGCTGGGTCTCACCCAGGGTCACCAGTCCTGTGAC
TTCCTAGATGCAGCCAGCCAACTTCAAAAACTCCAGGAACTCTTGGAAACACATATTCTT
CCCACGGAGCAAGAGCCATCCAGGGAAGTCACCAGTTTTGCCATCCTGAGCTCAGAAGAA
GGAAAAAAGCCCATCTCAAATGGCCTGTCCAAATGGTTGACTTCAGTCTGCTGGCTCCTC
TTAGGTTTCACTAGCCTGGCTTCAGCCTTTTTTACAGCACTTTATAGCTTGGAATTGAGC
AAAGACCAAGCCACCAGCTGGATGATTTCAATTATTTTATCAGTGCTTCAGAACATCTTC
ATCAGCCAGCCAGTAAAGGTGGTCTTCTTCACATTCTTATACTCACTGATGATGAGCAGG
ATGCCACGGCTTAACAAAGAGAATGAACAACAAACAAAGAGGATCTTGGCACTCTTGGCA
AAATGTTCTTCGTCAGTACCAGGTTCAAGAGATAAGAACAACCCCGTCTATGTAGCCCCA
GCTATAAATAGTCCAACTAAGCACCCAGAAAGAACCTTGAAAAAGAAGAAACTCTTCAAG
CTGACTGGAGATATTTTGGTACAAATCCTCTTCCTTACCCTGTTGATGACTGCAATCTAC
TCTGCAAAGAACTCCAATAGATTTTACCTCCACCAAGCTATCTGGAAGACATTTTCGCAC
CAGTTCTCGGAAATCAAACTTCTTCAGGATTTCTACCCCTGGGCCAATCATATCCTTCTT
CCTAGCCTGTATGGGGATTACAGAGGTAAGAATGCAGTCCTGGAGCCCAGTCATTGCAAA
TGTGGGGTACAATTAATTTTCCAAATACCCCGTACCAAGACCTATGAGAAAGTGGACGAA
GGTCAGCTGGCGTTTTGTGATAACGGCCATACCTGTGGGCGTCCCAAGAGCCTATTCCCT
GGACTTCATCTAAGGAGGTTCAGTTACATCTGTTCACCCAGGCCCATGGTGCTGATTCCC
ACTGATGAGCTTCACGAAAGGCTGACAAGCAAGAATGAGAATGGATTCAGTTACATCATG
AGAGGTGCTTTCTTCACCTCTTTGAGACTGGAAAGCTTCACTTCCCTTCAGATGTCAAAG
AAGGGCTGTGTCTGGTCTATCATCTCACAAGTCATCTATTATCTACTGGTCTGTTACTAT
GCCTTCATACAGGGTTGTCAGCTGAAACAGCAGAAGTGGAGGTTCTTCACTGGGAAAAGA
AACATTCTGGACACAAGTATAATCCTCATTAGCTTCATCCTCCTGGGGCTTGACATGAAG
AGTATTTCTCTACATAAGAAAAACATGGCACGATACCGCGATGACCAGGACAGATTCATC
AGCTTCTATGAGGCAGTAAAAGTGAACTCTGCTGCGACTCACCTTGTGGGCTTCCCGGTT
CTCCTGGCAACTGTTCAGTTATGGAACCTGCTGCGTCATAGCCCCAGGCTGCGGGTCATC
AGCAGGACACTGAGCCGAGCCTGGGACGAGGTGGTGGGCTTTCTGCTGATCATCCTAATC
CTGCTGACAGGCTATGCCATTGCCTTTAACCTGCTGTTTGGATGCAGCATCTCTGACTAC
CGGACATTTTTCAGCTCAGCAGTGACTGTTGTTGGTCTCCTGATGGGAATTTCTCACCAA
GAGGAGGTTTTCGCTTTAGACCCAGTCCTGGGCACCTTTCTGATCCTCACCAGTGTCATC
TTGATGGTACTTGTGGTAATTAATCTTTTCGTTTCGGCCATTCTCATGGCCTTTGGAAAA
GAAAGAAAGTCGCTTAAGAAAGAAGCTGCACTAATAGATACACTGCTACAGAAGCTCTCA
AATTTGTTAGGAATCAGTTGGCCCCAAAAAACCTCATCTGAGCAAGCAGCCACGACAGCA
GTGGGCAGTGACACTGAAGTTTTAGATGAACTACCTTAA
Chromosome Location
16
Locus
16q22.2
External Identifiers
ResourceLink
UniProtKB IDQ7Z443
UniProtKB Entry NamePK1L3_HUMAN
HGNC IDHGNC:21716
General References
  1. Li A, Tian X, Sung SW, Somlo S: Identification of two novel polycystic kidney disease-1-like genes in human and mouse genomes. Genomics. 2003 Jun;81(6):596-608. [Article]
  2. Inada H, Kawabata F, Ishimaru Y, Fushiki T, Matsunami H, Tominaga M: Off-response property of an acid-activated cation channel complex PKD1L3-PKD2L1. EMBO Rep. 2008 Jul;9(7):690-7. doi: 10.1038/embor.2008.89. Epub 2008 Jun 6. [Article]
  3. Ishii S, Misaka T, Kishi M, Kaga T, Ishimaru Y, Abe K: Acetic acid activates PKD1L3-PKD2L1 channel--a candidate sour taste receptor. Biochem Biophys Res Commun. 2009 Jul 31;385(3):346-50. doi: 10.1016/j.bbrc.2009.05.069. Epub 2009 May 21. [Article]
  4. Huque T, Cowart BJ, Dankulich-Nagrudny L, Pribitkin EA, Bayley DL, Spielman AI, Feldman RS, Mackler SA, Brand JG: Sour ageusia in two individuals implicates ion channels of the ASIC and PKD families in human sour taste perception at the anterior tongue. PLoS One. 2009 Oct 8;4(10):e7347. doi: 10.1371/journal.pone.0007347. [Article]
  5. Ishimaru Y, Katano Y, Yamamoto K, Akiba M, Misaka T, Roberts RW, Asakura T, Matsunami H, Abe K: Interaction between PKD1L3 and PKD2L1 through their transmembrane domains is required for localization of PKD2L1 at taste pores in taste cells of circumvallate and foliate papillae. FASEB J. 2010 Oct;24(10):4058-67. doi: 10.1096/fj.10-162925. Epub 2010 Jun 10. [Article]
  6. Ishii S, Kurokawa A, Kishi M, Yamagami K, Okada S, Ishimaru Y, Misaka T: The response of PKD1L3/PKD2L1 to acid stimuli is inhibited by capsaicin and its pungent analogs. FEBS J. 2012 May;279(10):1857-70. doi: 10.1111/j.1742-4658.2012.08566.x. Epub 2012 Apr 16. [Article]
  7. Yu Y, Ulbrich MH, Li MH, Dobbins S, Zhang WK, Tong L, Isacoff EY, Yang J: Molecular mechanism of the assembly of an acid-sensing receptor ion channel complex. Nat Commun. 2012;3:1252. doi: 10.1038/ncomms2257. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB11093Calcium citrateapproved, investigationalunknownsubstrateDetails
DB11348Calcium PhosphateapprovedunknownsubstrateDetails
DB14481Calcium phosphate dihydrateapprovedunknownDetails