RNA-directed RNA polymerase catalytic subunit
Details
- Name
- RNA-directed RNA polymerase catalytic subunit
- Synonyms
- 2.7.7.48
- PB1
- Polymerase basic protein 1
- RNA-directed RNA polymerase subunit P1
- Gene Name
- PB1
- Organism
- Influenza A virus (strain A/Silky Chicken/Hong Kong/SF189/2001 H5N1 genotype A)
- Amino acid sequence
>lcl|BSEQ0052300|RNA-directed RNA polymerase catalytic subunit MDVNPTLLFLKVPAQNAISTTFPYTGDPPYSHGTGTGYTMDTVNRTHQYSEKGKWTTNTE TGAPQLNPIDGPLPEDNEPSGYAQTDCVLEAMAFLEESHPGIFENSCLETMEIVQQTRVD KLTQGRQTYDWTLNRNQPAATALANTIEIFRSNGLTANESGRLIDFLKDVMESMDKEEME ITTHFQRKRRVRDNMTKKMVTQRTIGKKKQRLNKKSYLIRALTLNTMTKDAERGKLKRRA IATPGMQIRGFVYFVETLARSICEKLEQSGLPVGGNEKKAKLANVVRKMMTNSQDTELSF TITGDNTKWNENQNPRMFLAMITYITRNQPEWFRNVLSIAPIMFSNKMARLGKGYMFESK SMKLRTQIPAEMLANIDLKYFNESTRKKIEKIRPLLIDGTASLSPGMMMGMFNMLSTVLG VSILNLGQKRYTKTTYWWDGLQSSDDFALIVNAPNHEGIQAGVDRFYRTCKLVGINMSKK KSYINRTGTFEFTSFFYRYGFVANFSMELPSFGVSGINESADMSIGVTVIKNNMINNDLG PATAQMALQLFIKDYRYTYRCHRGDTQIQTRRSFELKKLWEQTRSKAGLLVSDGGPNLYN IRNLHIPEVCLKWELMDEDYQGRLCNPLNPFVSHKEIESVNNAVVMPAHGPAKSVEYDAV ATTHSWIPKRNRSILNTSQRGILEDEQMYQKCCNLFEKFFPSSSYRRPVGISSMVEAMVS RARIDARIDFESGRIKKEEFAEIMKICSTIEELRRQK
- Number of residues
- 757
- Molecular Weight
- 86420.48
- Theoretical pI
- Not Available
- GO Classification
- Functionsnucleotide binding / RNA binding / RNA-directed 5'-3' RNA polymerase activityProcessessuppression by virus of host RNA polymerase II activity / transcription, DNA-templated / viral RNA genome replication / viral transcriptionComponentshost cell cytoplasm / host cell nucleus
- General Function
- RNA-dependent RNA polymerase which is responsible for replication and transcription of virus RNA segments. The transcription of viral mRNAs occurs by a unique mechanism called cap-snatching. 5' methylated caps of cellular mRNAs are cleaved after 10-13 nucleotides by PA. In turn, these short capped RNAs are used as primers by PB1 for transcription of viral mRNAs. During virus replication, PB1 initiates RNA synthesis and copy vRNA into complementary RNA (cRNA) which in turn serves as a template for the production of more vRNAs.
- Specific Function
- Nucleotide binding
- Pfam Domain Function
- Flu_PB1 (PF00602)
- Transmembrane Regions
- Not Available
- Cellular Location
- Host nucleus
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q809M3 UniProtKB Entry Name RDRP_I01A0 - General References
- Guan Y, Peiris JS, Lipatov AS, Ellis TM, Dyrting KC, Krauss S, Zhang LJ, Webster RG, Shortridge KF: Emergence of multiple genotypes of H5N1 avian influenza viruses in Hong Kong SAR. Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8950-5. doi: 10.1073/pnas.132268999. Epub 2002 Jun 19. [Article]