Cytochrome P450

Details

Name
Cytochrome P450
Synonyms
Not Available
Gene Name
staP
Organism
Streptomyces sp. TP-A0274
Amino acid sequence
>lcl|BSEQ0012625|Cytochrome P450
MASATLPRFDLMGWDKKDIADPYPVYRRYREAAPVHRTASGPGKPDTYYVFTYDDVVRVL
SNRRLGRNARVASGDTDTAPVPIPTEHRALRTVVENWLVFLDPPHHTELRSLLTTEFSPS
IVTGLRPRIAELASALLDRLRAQRRPDLVEGFAAPLPILVISALLGIPEEDHTWLRANAV
ALQEASTTRARDGRGYARAEAASQEFTRYFRREVDRRGGDDRDDLLTLLVRARDTGSPLS
VDGIVGTCVHLLTAGHETTTNFLAKAVLTLRAHRDVLDELRTTPESTPAAVEELMRYDPP
VQAVTRWAYEDIRLGDHDIPRGSRVVALLGSANRDPARFPDPDVLDVHRAAERQVGFGLG
IHYCLGATLARAEAEIGLRALLDGIPALGRGAHEVEYADDMVFHGPTRLLLDLPDAA
Number of residues
417
Molecular Weight
46125.6
Theoretical pI
6.33
GO Classification
Functions
heme binding / iron ion binding / monooxygenase activity / oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
General Function
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
Specific Function
Not Available
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0007215|2832 bp
ATGAGGGAGAAAATGCACAGCTGTTCACGGTCGGCAATGGCAAAGTGCGAGAATCCGGTT
CTCAACGCAGTTCACACACAGCCCATTTCCCGGGGAGCAGTGCACGGCAGGGAAGACCAA
CTGGCCCAGACGATCACGCAGCTGCGCGCCGTGGCGAGCAGCGGGCGGAGCACGGTGCTG
GTGCTGGGGGCGGTTCCCGGCGCCGGCAAGACCCGGCTCCTCAGGGAGGCGGCGTCGCTC
GCCGAGAGCGACGGCTTCATGGTGCTGAGCGCCGCCCCGGCCGGGCCCGACACCACCCCC
GAGGCCGTCATCGAGGCGGCGCGGACACGGCTCCCCGGCGCCGGGAGCACCCGCACCACC
GTCGTCCTCGACGATCTGCATCTGGCGGGACTCCCCGCACTGACGACGCTGAACGACCTC
GTCGTGGCCCTCAGGGGACGTCCGATCCTCTGGCTGCTCGCCTTCACCACGGAACGCGAC
GCCCCACCCCCGGAACACCTGCGGGCCTCTCTCGGCGGACTCCGCGCCAGCCTCCCGGTG
GAGCACATGCGGGAGCTGGGACCGATCGAGGGCGACGCGCTGGCACAGTTGGTCGCCGAC
CACACCGGAGCCACCCCCGACCCGGCTCTCCTCGCCCTCGCGGAGAGCGTCAACGCCACG
CCGCGCTCGGTGATCGAGTTGATTCGCGGCCTGGCGGAGGACGACGACCTGTGCCTGATC
GACGGCACCACCCGATTACAGCCCGGCCCACCCGGCGACCCCTCGGCCGGGTGGGGCGTC
CCGGTGCCCACCCCCGTACCGAAACGGTTCTCCGCGACCGTCCAGCAAGACCTCAGGACA
CTGTCGGACCCCACCCTGAAGGCGCTCAGACTGGCCGCCGTCCTCGGATCACCGTTCGCA
CCGGAAGACCTGTCGGCCCTGCTCGACGAAGCACCCGTCGGTCTGCTCGCCGCCGTGGAC
GAGGCCGTCGACCGGGGCCTGCTCGTCTGCGGCGAACGCGACCTCGCCTTCCGCACCGAG
CCGATCTGGCGGGTCCTGCTCGACTCCGTACCGCCCCCGGTGCTCGCCCTGCTGCGCCGG
CAGGCCGCGAAGATCGTGCTGCCGCGCCCCGACGGCGTCGAGCGCGCCGCCCTCCAACTG
GTCCACGTCGCCCAACCCGGCAACACGGACGAACTGCGCATCATCGCCGAGGGCTCCCGC
AGACTCCTGCTCGCCGACCCGTCCGCAGCCGCCTCGCTCGCCACCCGCTCCATGGAGTTC
CTGGACCCCGGCACCGCCGAGCGGGTGCGACTGGCACGGACCGCCGTCGAAGCGCTCACC
AGAGCCGGCCGACTGGACCACGCGATCGCCCTGGCCAAGGACACCGTCGACGAGACAGCC
CGCCTCGCCGCCCCACTGCCGCCGGAGCTCGTCGAGGACGTCGCCGCGTTGCGGGCCTCG
ATGTCGACCGCCCTGCTGCTCCTCGGCGACGCCCGCCTCGCCCGCCGAGCGGCAGGCGAC
GCGCTCGCGGTACAGCACGGCGGGCCCCAGCACCGCGAGGCGGTCGTCGCCCACCTCGCC
GCCTCCTACCTCACCGGCGACGCCAGCGCCGCCCAGCGCGCACGCCAGATCCTCGGCGCA
CCCGACCGCCACACCGGCGCCGTGCAGGTGGGCGCGATGACCTTCCACGCCTTCGGCCAG
TGGCGCGCCGGCGACGTCGGCGAGGCCGTGGCCACCCTGCGCAGGGCGGTCGCCCTCGAC
CGCGCCGACGACGAGGCGCCGATCCTCGACCCCCGCTGGTTCCTCACCTTCACCCTCGCC
AGGACCGACGAGTACGAGCAGGCGGCGGCCGTCATCCGGAGCTCCGCCGCCATCGCCTCG
AAACACGGCACGCTGACCACCGCGGTCCCCGCCGTGCTCCGCGCCCAACTGAACCTCGCA
CAGGGCCGGTTGGACGAGGCGGAGGACGACGCCAAGCTCGGGGTCGGCACCGACGGCCCC
TTTGTGCCGATGCTCGCCCCGCAGGCATGGCTGGTTCTAGCCTCCGTGGCCCTGCGCCGA
GGAGCGCTCGCCCAGGCCGAGGAACACATCAAGACCCTGGAGAAGGACTTCCCCCAGCAC
GCCTCCAGCCCCTGGTGGGGCGCGCGGCTGCTGCTCAACGCGCAGTTGGCCGAGGCACAG
GCCGACCAGCACGCCGCGACGGAGGTGCTGGCCGAGATCGGGGCGCAGAACGGTGCGCTC
CGCGAGGTCGTCCTGGAGGATCCGGCCGCGGCGGCCTGGTGGGTACGGTGCGCTCTCGCG
GCCGAGCGACCCGACCTCGTCTCGACGGTGATCGAGGCGACGGAGCACCTCCGTGGACGC
AACCAGTGCGTGCCCTCGGTGGTGGCCATGGCCATGCACGCCCGGGCGCTCGCCGAAGGG
GACGCCGAGGCACTCGACCGGGCCGGGCGGCTACACCGCAATCCCTGGGCGCAGGCGACC
GCGGCCGAGGACCACGCGGGGCTGCTCCTCGACCGTGGGGAGCACGAGGCCGCCATCGGT
GAGTTCGACCGGGCGATGAGCGCCTTCGGCGCGCTCGGCGGGGAGCGGGACGCCGCCCGG
GTGCGGGCGCGGCTGCGTGCGCTGGGGGTACGGCGGCGGCACTGGACGCATGCGAAACGT
CCGGTGTCCGGGTGGGAGAGCCTGACCAAGACCGAGCGGAAGGTGGCCGAGCTGGTGGCC
GGGGGGCTCACCAATCAGCAGGCCGCCCGGCATCTGTTCATCTCACCGCACACGGTCGGG
TTCCATCTGCGCCAGATCTACCGGAAGTTGGGCATCCGGTCGCGCACCGCGCTGATTCGG
CTGAGGGCGTGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ83WG3
UniProtKB Entry NameQ83WG3_9ACTN
GenBank Protein ID27753571
GenBank Gene IDAB088119
General References
  1. Makino M, Sugimoto H, Shiro Y, Asamizu S, Onaka H, Nagano S: Crystal structures and catalytic mechanism of cytochrome P450 StaP that produces the indolocarbazole skeleton. Proc Natl Acad Sci U S A. 2007 Jul 10;104(28):11591-6. Epub 2007 Jul 2. [Article]
  2. Wang Y, Chen H, Makino M, Shiro Y, Nagano S, Asamizu S, Onaka H, Shaik S: Theoretical and experimental studies of the conversion of chromopyrrolic acid to an antitumor derivative by cytochrome P450 StaP: the catalytic role of water molecules. J Am Chem Soc. 2009 May 20;131(19):6748-62. doi: 10.1021/ja9003365. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB069553,4-bis(7-chloro-1H-indol-3-yl)-1H-pyrrole-2,5-dicarboxylic acidexperimentalunknownDetails
DB075883,4-DI-1H-INDOL-3-YL-1H-PYRROLE-2,5-DICARBOXYLIC ACIDexperimentalunknownDetails