Deoxyuridine 5'-triphosphate nucleotidohydrolase, putative

Details

Name
Deoxyuridine 5'-triphosphate nucleotidohydrolase, putative
Synonyms
Not Available
Gene Name
Not Available
Organism
Plasmodium falciparum (isolate 3D7)
Amino acid sequence
>lcl|BSEQ0012343|Deoxyuridine 5'-triphosphate nucleotidohydrolase, putative
MHLKIVCLSDEVREMYKNHKTHHEGDSGLDLFIVKDEVLKPKSTTFVKLGIKAIALQYKS
NYYYKCEKSENKKKDDDKSNIVNTSFLLFPRSSISKTPLRLANSIGLIDAGYRGEIIAAL
DNTSDQEYHIKKNDKLVQLVSFTGEPLSFELVEELDETSRGEGGFGSTSNNKY
Number of residues
173
Molecular Weight
19572.98
Theoretical pI
7.06
GO Classification
Functions
dUTP diphosphatase activity
Processes
DNA replication / dUTP metabolic process / tRNA metabolic process
General Function
Dutp diphosphatase activity
Specific Function
Not Available
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0012344|Deoxyuridine 5'-triphosphate nucleotidohydrolase, putative
ATGCATTTAAAAATTGTATGTCTGAGTGATGAGGTCAGAGAAATGTACAAGAATCATAAA
ACACATCATGAAGGTGATAGTGGATTAGATTTGTTTATTGTAAAAGATGAAGTACTGAAG
CCAAAGTCCACAACTTTTGTTAAGCTTGGAATTAAGGCAATAGCATTACAATATAAATCT
AATTATTATTATAAATGTGAAAAATCGGAAAATAAAAAAAAAGATGATGACAAATCCAAT
ATTGTAAATACGAGCTTTTTATTATTTCCTCGTAGCAGTATATCCAAAACCCCATTACGC
TTAGCTAATTCAATTGGACTAATTGATGCAGGTTATAGAGGAGAAATTATTGCCGCCTTG
GATAATACTAGTGACCAAGAGTATCACATTAAAAAAAATGATAAATTAGTACAATTGGTC
TCTTTTACAGGGGAACCACTTTCTTTTGAATTAGTTGAGGAACTGGATGAAACTTCCAGA
GGAGAAGGAGGTTTTGGATCGACATCGAATAATAAATATTGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ8II92
UniProtKB Entry NameQ8II92_PLAF7
GenBank Gene IDAE014840
General References
  1. Gardner MJ, Hall N, Fung E, White O, Berriman M, Hyman RW, Carlton JM, Pain A, Nelson KE, Bowman S, Paulsen IT, James K, Eisen JA, Rutherford K, Salzberg SL, Craig A, Kyes S, Chan MS, Nene V, Shallom SJ, Suh B, Peterson J, Angiuoli S, Pertea M, Allen J, Selengut J, Haft D, Mather MW, Vaidya AB, Martin DM, Fairlamb AH, Fraunholz MJ, Roos DS, Ralph SA, McFadden GI, Cummings LM, Subramanian GM, Mungall C, Venter JC, Carucci DJ, Hoffman SL, Newbold C, Davis RW, Fraser CM, Barrell B: Genome sequence of the human malaria parasite Plasmodium falciparum. Nature. 2002 Oct 3;419(6906):498-511. [Article]
  2. Whittingham JL, Leal I, Nguyen C, Kasinathan G, Bell E, Jones AF, Berry C, Benito A, Turkenburg JP, Dodson EJ, Ruiz Perez LM, Wilkinson AJ, Johansson NG, Brun R, Gilbert IH, Gonzalez Pacanowska D, Wilson KS: dUTPase as a platform for antimalarial drug design: structural basis for the selectivity of a class of nucleoside inhibitors. Structure. 2005 Feb;13(2):329-38. [Article]
  3. Baragana B, McCarthy O, Sanchez P, Bosch-Navarrete C, Kaiser M, Brun R, Whittingham JL, Roberts SM, Zhou XX, Wilson KS, Johansson NG, Gonzalez-Pacanowska D, Gilbert IH: beta-Branched acyclic nucleoside analogues as inhibitors of Plasmodium falciparum dUTPase. Bioorg Med Chem. 2011 Apr 1;19(7):2378-91. doi: 10.1016/j.bmc.2011.02.012. Epub 2011 Feb 17. [Article]
  4. Hampton SE, Baragana B, Schipani A, Bosch-Navarrete C, Musso-Buendia JA, Recio E, Kaiser M, Whittingham JL, Roberts SM, Shevtsov M, Brannigan JA, Kahnberg P, Brun R, Wilson KS, Gonzalez-Pacanowska D, Johansson NG, Gilbert IH: Design, synthesis, and evaluation of 5'-diphenyl nucleoside analogues as inhibitors of the Plasmodium falciparum dUTPase. ChemMedChem. 2011 Oct 4;6(10):1816-31. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB046851-{(2S,5S)-4-FLUORO-5-[(TRITYLOXY)METHYL]TETRAHYDROFURAN-2-YL}PYRIMIDINE-2,4(1H,3H)-DIONEexperimentalunknownDetails