V-type proton ATPase subunit d 2
Details
- Name
- V-type proton ATPase subunit d 2
- Synonyms
- V-ATPase subunit d 2
- Vacuolar proton pump subunit d 2
- Gene Name
- ATP6V0D2
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0052433|V-type proton ATPase subunit d 2 MLEGAELYFNVDHGYLEGLVRGCKASLLTQQDYINLVQCETLEDLKIHLQTTDYGNFLAN HTNPLTVSKIDTEMRKRLCGEFEYFRNHSLEPLSTFLTYMTCSYMIDNVILLMNGALQKK SVKEILGKCHPLGRFTEMEAVNIAETPSDLFNAILIETPLAPFFQDCMSENALDELNIEL LRNKLYKSYLEAFYKFCKNHGDVTAEVMCPILEFEADRRAFIITLNSFGTELSKEDRETL YPTFGKLYPEGLRLLAQAEDFDQMKNVADHYGVYKPLFEAVGGSGGKTLEDVFYEREVQM NVLAFNRQFHYGVFYAYVKLKEQEIRNIVWIAECISQRHRTKINSYIPIL
- Number of residues
- 350
- Molecular Weight
- 40426.005
- Theoretical pI
- Not Available
- GO Classification
- Functionsproton-exporting ATPase activity, phosphorylative mechanism / proton-transporting ATPase activity, rotational mechanismProcessesinsulin receptor signaling pathway / ion transmembrane transport / phagosome acidification / regulation of macroautophagy / transferrin transport / vacuolar acidification / vacuolar transportComponentsapical plasma membrane / cell / early endosome / endosome membrane / extracellular exosome / lysosomal membrane / membrane / phagocytic vesicle membrane / plasma membrane proton-transporting V-type ATPase complex / proton-transporting V-type ATPase, V0 domain / vacuolar proton-transporting V-type ATPase complex
- General Function
- Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis (By similarity).
- Specific Function
- Proton-exporting atpase activity, phosphorylative mechanism
- Pfam Domain Function
- vATP-synt_AC39 (PF01992)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0052434|V-type proton ATPase subunit d 2 (ATP6V0D2) ATGCTCGAAGGTGCGGAGCTGTACTTCAACGTGGACCATGGCTACCTGGAGGGCCTGGTT CGAGGATGCAAGGCCAGCCTCCTGACCCAGCAAGACTATATCAACCTGGTCCAGTGTGAG ACCCTAGAAGACCTGAAAATTCATCTCCAGACTACTGATTATGGTAACTTTTTGGCTAAT CACACAAATCCTCTTACTGTTTCCAAAATTGACACTGAGATGAGGAAAAGACTATGTGGA GAATTTGAGTATTTCCGGAATCATTCCCTGGAGCCCCTCAGCACATTTCTCACCTATATG ACGTGCAGTTATATGATAGACAATGTGATTCTGCTGATGAATGGTGCATTGCAGAAAAAA TCTGTGAAAGAAATTCTGGGGAAGTGCCACCCCTTGGGCCGTTTCACAGAAATGGAAGCT GTCAACATTGCAGAGACACCTTCAGATCTCTTTAATGCCATTCTGATCGAAACGCCATTA GCTCCATTCTTCCAAGACTGCATGTCTGAAAATGCTCTAGATGAACTGAATATTGAATTG CTACGCAATAAACTATACAAGTCTTACCTTGAGGCATTCTATAAATTCTGTAAGAATCAT GGTGATGTCACAGCAGAAGTTATGTGTCCCATTCTTGAGTTTGAGGCCGACAGACGTGCT TTTATCATCACTCTTAACTCCTTTGGCACTGAATTGAGCAAAGAAGACCGAGAGACCCTC TATCCAACCTTCGGCAAACTCTATCCTGAGGGGTTGCGGCTGTTGGCTCAAGCAGAAGAC TTTGACCAGATGAAGAACGTAGCGGATCATTACGGAGTATACAAACCTTTATTTGAAGCT GTAGGTGGCAGTGGGGGAAAGACATTGGAGGACGTGTTTTACGAGCGTGAGGTACAAATG AATGTGCTGGCATTCAACAGACAGTTCCACTACGGTGTGTTTTATGCATATGTAAAGCTG AAGGAACAGGAAATTAGAAATATTGTGTGGATAGCAGAATGTATTTCACAGAGGCATCGA ACTAAAATCAACAGTTACATTCCAATTTTATAA
- Chromosome Location
- 8
- Locus
- 8q21.3
- External Identifiers
Resource Link UniProtKB ID Q8N8Y2 UniProtKB Entry Name VA0D2_HUMAN HGNC ID HGNC:18266 - General References
- Smith AN, Borthwick KJ, Karet FE: Molecular cloning and characterization of novel tissue-specific isoforms of the human vacuolar H(+)-ATPase C, G and d subunits, and their evaluation in autosomal recessive distal renal tubular acidosis. Gene. 2002 Sep 4;297(1-2):169-77. [Article]
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