Estradiol 17-beta-dehydrogenase 11
Details
- Name
- Estradiol 17-beta-dehydrogenase 11
- Synonyms
- 1.1.1.62
- 17-beta-HSD 11
- 17-beta-HSD XI
- 17-beta-hydroxysteroid dehydrogenase 11
- 17-beta-hydroxysteroid dehydrogenase XI
- 17betaHSD11
- 17betaHSDXI
- 17bHSD11
- CTCL-associated antigen HD-CL-03
- Cutaneous T-cell lymphoma-associated antigen HD-CL-03
- Dehydrogenase/reductase SDR family member 8
- DHRS8
- PAN1B
- Retinal short-chain dehydrogenase/reductase 2
- retSDR2
- SDR16C2
- Short chain dehydrogenase/reductase family 16C member 2
- Gene Name
- HSD17B11
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0016906|Estradiol 17-beta-dehydrogenase 11 MKFLLDILLLLPLLIVCSLESFVKLFIPKRRKSVTGEIVLITGAGHGIGRLTAYEFAKLK SKLVLWDINKHGLEETAAKCKGLGAKVHTFVVDCSNREDIYSSAKKVKAEIGDVSILVNN AGVVYTSDLFATQDPQIEKTFEVNVLAHFWTTKAFLPAMTKNNHGHIVTVASAAGHVSVP FLLAYCSSKFAAVGFHKTLTDELAALQITGVKTTCLCPNFVNTGFIKNPSTSLGPTLEPE EVVNRLMHGILTEQKMIFIPSSIAFLTTLERILPERFLAVLKQKISVKFDAVIGYKMKAQ
- Number of residues
- 300
- Molecular Weight
- 32935.525
- Theoretical pI
- 9.7
- GO Classification
- Functionsestradiol 17-beta-dehydrogenase activity / steroid dehydrogenase activityProcessesandrogen catabolic process / estrogen biosynthetic process / small molecule metabolic process / steroid metabolic processComponentscytoplasm / cytosol / extracellular region / intracellular membrane-bounded organelle / lipid particle
- General Function
- Steroid dehydrogenase activity
- Specific Function
- Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor-associated antigen in cutaneous T-cell lymphoma.
- Pfam Domain Function
- adh_short (PF00106)
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Gene sequence
>lcl|BSEQ0016907|Estradiol 17-beta-dehydrogenase 11 (HSD17B11) ATGAAATTTCTTCTGGACATCCTCCTGCTTCTCCCGTTACTGATCGTCTGCTCCCTAGAG TCCTTCGTGAAGCTTTTTATTCCTAAGAGGAGAAAATCAGTCACCGGCGAAATCGTGCTG ATTACAGGAGCTGGGCATGGAATTGGGAGACTGACTGCCTATGAATTTGCTAAACTTAAA AGCAAGCTGGTTCTCTGGGATATAAATAAGCATGGACTGGAGGAAACAGCTGCCAAATGC AAGGGACTGGGTGCCAAGGTTCATACCTTTGTGGTAGACTGCAGCAACCGAGAAGATATT TACAGCTCTGCAAAGAAGGTGAAGGCAGAAATTGGAGATGTTAGTATTTTAGTAAATAAT GCTGGTGTAGTCTATACATCAGATTTGTTTGCTACACAAGATCCTCAGATTGAAAAGACT TTTGAAGTTAATGTACTTGCACATTTCTGGACTACAAAGGCATTTCTTCCTGCAATGACG AAGAATAACCATGGCCATATTGTCACTGTGGCTTCGGCAGCTGGACATGTCTCGGTCCCC TTCTTACTGGCTTACTGTTCAAGCAAGTTTGCTGCTGTTGGATTTCATAAAACTTTGACA GATGAACTGGCTGCCTTACAAATAACTGGAGTCAAAACAACATGTCTGTGTCCTAATTTC GTAAACACTGGCTTCATCAAAAATCCAAGTACAAGTTTGGGACCCACTCTGGAACCTGAG GAAGTGGTAAACAGGCTGATGCATGGGATTCTGACTGAGCAGAAGATGATTTTTATTCCA TCTTCTATAGCTTTTTTAACAACATTGGAAAGGATCCTTCCTGAGCGTTTCCTGGCAGTT TTAAAACGAAAAATCAGTGTTAAGTTTGATGCAGTTATTGGATATAAAATGAAAGCGCAA TAA
- Chromosome Location
- 4
- Locus
- 4q22.1
- External Identifiers
Resource Link UniProtKB ID Q8NBQ5 UniProtKB Entry Name DHB11_HUMAN GenBank Gene ID AF126780 GenAtlas ID HSD17B11 HGNC ID HGNC:22960 - General References
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