Cation channel sperm-associated protein 1
Details
- Name
- Cation channel sperm-associated protein 1
- Synonyms
- CatSper1
- Gene Name
- CATSPER1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0049531|Cation channel sperm-associated protein 1 MDQNSVPEKAQNEADTNNADRFFRSHSSPPHHRPGHSRALHHYELHHHGVPHQRGESHHP PEFQDFHDQALSSHVHQSHHHSEARNHGRAHGPTGFGLAPSQGAVPSHRSYGEDYHDELQ RDGRRHHDGSQYGGFHQQSDSHYHRGSHHGRPQYLGENLSHYSSGVPHHGEASHHGGSYL PHGPNPYSESFHHSEASHLSGLQHDESQHHQVPHRGWPHHHQVHHHGRSRHHEAHQHGKS PHHGETISPHSSVGSYQRGISDYHSEYHQGDHHPSEYHHGDHPHHTQHHYHQTHRHRDYH QHQDHHGAYHSSYLHGDYVQSTSQLSIPHTSRSLIHDAPGPAASRTGVFPYHVAHPRGSA HSMTRSSSTIRSRVTQMSKKVHTQDISTKHSEDWGKEEGQFQKRKTGRLQRTRKKGHSTN LFQWLWEKLTFLIQGFREMIRNLTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYF MALDSIFFCIYVVEALLKIIALGLSYFFDFWNNLDFFIMAMAVLDFLLMQTHSFAIYHQS LFRILKVFKSLRALRAIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFLFSAV LRALFRKSDPKRFQNIFTTIFTLFTLLTLDDWSLIYMDSRAQGAWYIIPILVIYIIIQYF IFLNLVITVLVDSFQTALFKGLEKAKQERAARIQEKLLEDSLTELRAAEPKEVASEGTML KRLIEKKFGTMTEKQQELLFHYLQLVASVEQEQQKFRSQAAVIDEIVDTTFEAGEEDFRN
- Number of residues
- 780
- Molecular Weight
- 90090.225
- Theoretical pI
- Not Available
- GO Classification
- Functionscalcium activated cation channel activity / high voltage-gated calcium channel activityProcessescell differentiation / flagellated sperm motility / fusion of sperm to egg plasma membrane / membrane depolarization during action potential / multicellular organism development / regulation of calcium ion transport / regulation of cilium beat frequency involved in ciliary motility / response to progesterone / sperm-egg recognition / spermatogenesisComponentsCatSper complex / motile cilium / plasma membrane
- General Function
- Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte.
- Specific Function
- Calcium activated cation channel activity
- Pfam Domain Function
- Ion_trans (PF00520)
- Transmembrane Regions
- 446-466 486-506 516-536 542-562 580-600 647-667
- Cellular Location
- Cell projection
- Gene sequence
>lcl|BSEQ0049532|Cation channel sperm-associated protein 1 (CATSPER1) ATGGATCAAAACTCAGTGCCTGAAAAGGCTCAGAATGAGGCAGACACCAATAACGCAGAT AGGTTCTTTCGCTCTCACTCATCACCCCCACACCACAGGCCAGGCCACAGCAGAGCTCTC CACCATTACGAGTTGCACCATCACGGCGTGCCCCACCAACGTGGTGAATCTCACCACCCT CCGGAGTTCCAAGACTTCCACGACCAAGCCTTGTCCTCCCATGTCCACCAATCTCACCAC CACAGCGAGGCACGGAATCACGGCAGAGCCCATGGCCCCACAGGCTTTGGTCTGGCTCCC TCTCAAGGCGCCGTCCCCTCCCACCGTTCCTACGGTGAGGACTACCATGATGAGCTCCAA CGTGATGGCAGGAGGCATCATGATGGGTCCCAATACGGTGGGTTCCATCAGCAGAGTGAC TCCCATTACCATAGGGGGTCTCACCATGGCAGACCCCAATATCTCGGTGAGAATTTATCC CACTATTCCTCTGGCGTGCCCCACCACGGTGAGGCTTCCCACCATGGTGGGTCCTACCTC CCCCATGGACCCAATCCCTACAGTGAGTCCTTCCACCACAGCGAGGCTTCCCACCTTAGC GGGCTCCAACACGATGAGTCCCAGCATCACCAAGTCCCCCACCGTGGCTGGCCCCACCAT CACCAAGTCCACCACCATGGCAGGTCCCGTCATCATGAAGCCCACCAGCATGGAAAGTCT CCTCATCACGGAGAGACCATTTCCCCTCATTCCTCTGTGGGGTCCTACCAGCGTGGGATA TCTGACTATCACAGCGAGTACCACCAAGGTGATCACCACCCCAGTGAGTACCACCATGGC GACCATCCCCACCACACACAGCACCACTACCACCAGACCCACCGGCACCGAGACTACCAT CAGCACCAAGACCACCACGGCGCGTATCATTCCAGTTACCTCCATGGCGACTACGTCCAG AGCACTTCCCAACTCTCTATCCCACACACATCCCGGAGCCTGATTCACGATGCCCCCGGC CCTGCTGCTTCTCGTACAGGAGTCTTCCCCTATCACGTAGCACACCCACGGGGCTCGGCT CACAGCATGACTCGGTCCTCCAGCACAATCCGCTCACGTGTCACCCAGATGTCCAAAAAA GTCCATACCCAGGATATCTCCACCAAACATTCAGAAGACTGGGGCAAAGAAGAAGGGCAA TTTCAGAAACGCAAAACCGGCCGGCTCCAGCGGACCCGCAAGAAGGGACACTCTACCAAT CTCTTCCAGTGGCTGTGGGAAAAGCTAACCTTCCTCATTCAGGGCTTCCGGGAAATGATC CGGAACCTGACCCAATCCTTGGCCTTTGAAACTTTCATCTTCTTCGTTGTCTGCCTCAAC ACCGTCATGCTGGTGGCCCAGACCTTCGCTGAAGTCGAGATCCGGGGCGAGTGGTACTTC ATGGCCTTGGACTCCATATTCTTCTGCATCTACGTGGTGGAAGCCCTGCTCAAGATCATC GCCCTGGGCCTCTCGTACTTCTTTGACTTCTGGAACAATTTGGACTTCTTCATTATGGCC ATGGCCGTGCTGGACTTCTTGCTGATGCAGACCCACTCCTTCGCCATCTACCACCAAAGC CTCTTCCGGATCCTCAAGGTCTTCAAGAGCCTGCGGGCCCTGAGGGCAATCCGGGTCCTG CGGAGGCTCAGCTTCCTGACCAGCGTCCAGGAAGTGACAGGGACCCTGGGCCAGTCCTTG CCGTCCATCGCAGCCATCCTCATCCTCATGTTTACCTGCCTCTTCCTCTTCTCCGCGGTC CTCCGGGCACTGTTCCGCAAATCTGACCCCAAGCGCTTCCAGAACATCTTCACCACCATC TTCACCCTCTTCACCTTGCTCACGCTGGATGACTGGTCCCTCATCTACATGGACAGCCGT GCCCAGGGCGCCTGGTACATCATTCCCATCCTCGTAATTTACATCATCATCCAGTACTTC ATCTTCCTCAACCTGGTGATTACTGTCCTGGTGGATAGCTTCCAGACGGCGCTGTTCAAA GGCCTTGAGAAAGCGAAGCAGGAGAGGGCCGCCCGGATCCAAGAGAAGCTGCTGGAAGAC TCACTGACGGAGCTCAGAGCTGCAGAGCCCAAAGAGGTGGCGAGTGAAGGCACCATGCTG AAGCGGCTCATCGAGAAAAAGTTTGGGACCATGACTGAGAAGCAGCAGGAGCTCCTGTTC CATTACCTGCAGCTGGTGGCAAGCGTGGAGCAGGAGCAGCAGAAGTTCCGCTCCCAGGCA GCCGTCATCGATGAGATTGTGGACACCACATTTGAGGCTGGAGAAGAGGACTTCAGGAAT TGA
- Chromosome Location
- 11
- Locus
- 11q13.1
- External Identifiers
Resource Link UniProtKB ID Q8NEC5 UniProtKB Entry Name CTSR1_HUMAN HGNC ID HGNC:17116 - General References
- Ren D, Navarro B, Perez G, Jackson AC, Hsu S, Shi Q, Tilly JL, Clapham DE: A sperm ion channel required for sperm motility and male fertility. Nature. 2001 Oct 11;413(6856):603-9. [Article]
- Taylor TD, Noguchi H, Totoki Y, Toyoda A, Kuroki Y, Dewar K, Lloyd C, Itoh T, Takeda T, Kim DW, She X, Barlow KF, Bloom T, Bruford E, Chang JL, Cuomo CA, Eichler E, FitzGerald MG, Jaffe DB, LaButti K, Nicol R, Park HS, Seaman C, Sougnez C, Yang X, Zimmer AR, Zody MC, Birren BW, Nusbaum C, Fujiyama A, Hattori M, Rogers J, Lander ES, Sakaki Y: Human chromosome 11 DNA sequence and analysis including novel gene identification. Nature. 2006 Mar 23;440(7083):497-500. [Article]
- Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
- Nikpoor P, Mowla SJ, Movahedin M, Ziaee SA, Tiraihi T: CatSper gene expression in postnatal development of mouse testis and in subfertile men with deficient sperm motility. Hum Reprod. 2004 Jan;19(1):124-8. [Article]
- Li HG, Liao AH, Ding XF, Zhou H, Xiong CL: The expression and significance of CATSPER1 in human testis and ejaculated spermatozoa. Asian J Androl. 2006 May;8(3):301-6. [Article]
- Zhang D, Chen J, Saraf A, Cassar S, Han P, Rogers JC, Brioni JD, Sullivan JP, Gopalakrishnan M: Association of Catsper1 or -2 with Ca(v)3.3 leads to suppression of T-type calcium channel activity. J Biol Chem. 2006 Aug 4;281(31):22332-41. Epub 2006 Jun 1. [Article]
- Li HG, Ding XF, Liao AH, Kong XB, Xiong CL: Expression of CatSper family transcripts in the mouse testis during post-natal development and human ejaculated spermatozoa: relationship to sperm motility. Mol Hum Reprod. 2007 May;13(5):299-306. Epub 2007 Mar 8. [Article]
- Avenarius MR, Hildebrand MS, Zhang Y, Meyer NC, Smith LL, Kahrizi K, Najmabadi H, Smith RJ: Human male infertility caused by mutations in the CATSPER1 channel protein. Am J Hum Genet. 2009 Apr;84(4):505-10. doi: 10.1016/j.ajhg.2009.03.004. Epub 2009 Apr 2. [Article]
- Strunker T, Goodwin N, Brenker C, Kashikar ND, Weyand I, Seifert R, Kaupp UB: The CatSper channel mediates progesterone-induced Ca2+ influx in human sperm. Nature. 2011 Mar 17;471(7338):382-6. doi: 10.1038/nature09769. [Article]
- Lishko PV, Botchkina IL, Kirichok Y: Progesterone activates the principal Ca2+ channel of human sperm. Nature. 2011 Mar 17;471(7338):387-91. doi: 10.1038/nature09767. [Article]
- Miller MR, Mannowetz N, Iavarone AT, Safavi R, Gracheva EO, Smith JF, Hill RZ, Bautista DM, Kirichok Y, Lishko PV: Unconventional endocannabinoid signaling governs sperm activation via the sex hormone progesterone. Science. 2016 Apr 29;352(6285):555-9. doi: 10.1126/science.aad6887. Epub 2016 Mar 17. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB11093 Calcium citrate approved, investigational unknown substrate Details DB11348 Calcium Phosphate approved unknown substrate Details DB14481 Calcium phosphate dihydrate approved unknown Details DB14083 Bisphenol A diglycidyl ether approved, experimental unknown activator Details