V-type proton ATPase subunit C 2

Details

Name
V-type proton ATPase subunit C 2
Synonyms
  • V-ATPase subunit C 2
  • Vacuolar proton pump subunit C 2
Gene Name
ATP6V1C2
Organism
Humans
Amino acid sequence
>lcl|BSEQ0052449|V-type proton ATPase subunit C 2
MSEFWLISAPGDKENLQALERMNTVTSKSNLSYNTKFAIPDFKVGTLDSLVGLSDELGKL
DTFAESLIRRMAQSVVEVMEDSKGKVQEHLLANGVDLTSFVTHFEWDMAKYPVKQPLVSV
VDTIAKQLAQIEMDLKSRTAAYNTLKTNLENLEKKSMGNLFTRTLSDIVSKEDFVLDSEY
LVTLLVIVPKPNYSQWQKTYESLSDMVVPRSTKLITEDKEGGLFTVTLFRKVIEDFKTKA
KENKFTVREFYYDEKEIEREREEMARLLSDKKQQYQTSCVALKKGSSTFPDHKVKVTPLG
NPDRPAAGQTDRERESEGEGEGPLLRWLKVNFSEAFIAWIHIKALRVFVESVLRYGLPVN
FQAVLLQPHKKSSTKRLREVLNSVFRHLDEVAATSILDASVEIPGLQLNNQDYFPYVYFH
IDLSLLD
Number of residues
427
Molecular Weight
48758.35
Theoretical pI
Not Available
GO Classification
Functions
identical protein binding / proton-exporting ATPase activity, phosphorylative mechanism / proton-transporting ATPase activity, rotational mechanism
Processes
insulin receptor signaling pathway / ion transmembrane transport / phagosome acidification / positive regulation of Wnt signaling pathway / regulation of macroautophagy / transferrin transport
Components
cell / cytosol / extracellular exosome / lysosomal membrane / vacuolar proton-transporting V-type ATPase, V1 domain
General Function
Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
Specific Function
Identical protein binding
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0052450|V-type proton ATPase subunit C 2 (ATP6V1C2)
ATGTCGGAGTTTTGGTTAATTTCTGCCCCTGGCGATAAGGAAAATTTGCAAGCTCTGGAG
AGGATGAATACTGTAACCTCCAAGTCCAACCTGTCTTATAATACCAAATTCGCTATTCCT
GACTTCAAGGTGGGGACCTTGGATTCCCTGGTTGGCCTCTCTGATGAGTTGGGGAAACTC
GACACCTTTGCTGAAAGCCTCATAAGGAGAATGGCTCAGAGCGTGGTGGAAGTCATGGAG
GACTCAAAGGGGAAGGTCCAGGAGCACCTCCTGGCAAACGGAGTTGACTTAACATCCTTT
GTGACCCACTTTGAATGGGACATGGCCAAATATCCTGTCAAGCAGCCGCTCGTGAGTGTG
GTGGACACAATAGCCAAGCAACTGGCGCAGATCGAGATGGACCTGAAGTCCCGAACGGCC
GCCTACAACACTCTGAAGACAAACCTGGAGAACCTGGAAAAGAAATCCATGGGGAACCTC
TTCACCCGGACACTGAGTGATATTGTGAGCAAAGAGGACTTCGTGCTGGATTCTGAATAT
CTCGTCACACTTCTGGTCATCGTCCCCAAACCAAACTACTCACAATGGCAAAAAACCTAC
GAATCTCTCTCAGACATGGTGGTCCCTCGATCAACCAAACTCATTACTGAGGACAAGGAA
GGGGGCCTTTTCACTGTGACTCTGTTTCGAAAAGTGATTGAAGATTTCAAAACCAAGGCC
AAAGAAAACAAGTTCACTGTTCGTGAATTTTACTATGATGAGAAGGAAATTGAAAGGGAA
AGGGAGGAGATGGCCAGATTGCTGTCTGATAAGAAGCAACAGTATCAAACTTCCTGTGTT
GCTCTTAAAAAGGGATCATCCACCTTCCCGGACCACAAGGTTAAGGTAACCCCGCTAGGT
AACCCTGATAGGCCTGCTGCGGGGCAGACCGACAGAGAGAGAGAGAGTGAGGGCGAGGGT
GAGGGCCCCCTGCTGCGCTGGCTCAAGGTGAACTTCAGTGAAGCCTTCATTGCCTGGATC
CACATCAAGGCCCTGAGAGTGTTTGTGGAGTCCGTGCTCAGGTATGGACTACCAGTGAAC
TTCCAGGCAGTGCTCCTGCAGCCGCATAAGAAGTCATCCACCAAGCGTTTAAGAGAGGTT
CTAAACTCTGTCTTCCGACATCTGGATGAAGTAGCCGCTACAAGTATACTGGATGCATCT
GTGGAGATCCCGGGACTGCAACTCAATAACCAAGACTATTTTCCTTATGTCTACTTCCAT
ATTGACCTTAGTCTTCTTGACTAG
Chromosome Location
2
Locus
2p25.1
External Identifiers
ResourceLink
UniProtKB IDQ8NEY4
UniProtKB Entry NameVATC2_HUMAN
HGNC IDHGNC:18264
General References
  1. Smith AN, Borthwick KJ, Karet FE: Molecular cloning and characterization of novel tissue-specific isoforms of the human vacuolar H(+)-ATPase C, G and d subunits, and their evaluation in autosomal recessive distal renal tubular acidosis. Gene. 2002 Sep 4;297(1-2):169-77. [Article]
  2. Hillier LW, Graves TA, Fulton RS, Fulton LA, Pepin KH, Minx P, Wagner-McPherson C, Layman D, Wylie K, Sekhon M, Becker MC, Fewell GA, Delehaunty KD, Miner TL, Nash WE, Kremitzki C, Oddy L, Du H, Sun H, Bradshaw-Cordum H, Ali J, Carter J, Cordes M, Harris A, Isak A, van Brunt A, Nguyen C, Du F, Courtney L, Kalicki J, Ozersky P, Abbott S, Armstrong J, Belter EA, Caruso L, Cedroni M, Cotton M, Davidson T, Desai A, Elliott G, Erb T, Fronick C, Gaige T, Haakenson W, Haglund K, Holmes A, Harkins R, Kim K, Kruchowski SS, Strong CM, Grewal N, Goyea E, Hou S, Levy A, Martinka S, Mead K, McLellan MD, Meyer R, Randall-Maher J, Tomlinson C, Dauphin-Kohlberg S, Kozlowicz-Reilly A, Shah N, Swearengen-Shahid S, Snider J, Strong JT, Thompson J, Yoakum M, Leonard S, Pearman C, Trani L, Radionenko M, Waligorski JE, Wang C, Rock SM, Tin-Wollam AM, Maupin R, Latreille P, Wendl MC, Yang SP, Pohl C, Wallis JW, Spieth J, Bieri TA, Berkowicz N, Nelson JO, Osborne J, Ding L, Meyer R, Sabo A, Shotland Y, Sinha P, Wohldmann PE, Cook LL, Hickenbotham MT, Eldred J, Williams D, Jones TA, She X, Ciccarelli FD, Izaurralde E, Taylor J, Schmutz J, Myers RM, Cox DR, Huang X, McPherson JD, Mardis ER, Clifton SW, Warren WC, Chinwalla AT, Eddy SR, Marra MA, Ovcharenko I, Furey TS, Miller W, Eichler EE, Bork P, Suyama M, Torrents D, Waterston RH, Wilson RK: Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Nature. 2005 Apr 7;434(7034):724-31. [Article]
  3. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB01133Tiludronic acidapproved, investigational, vet_approvedunknowninhibitorDetails