Atypical kinase COQ8A, mitochondrial
Details
- Name
- Atypical kinase COQ8A, mitochondrial
- Synonyms
- 2.7.-.-
- aarF domain-containing protein kinase 3
- ADCK3
- CABC1
- Chaperone activity of bc1 complex-like
- Chaperone-ABC1-like
- Coenzyme Q protein 8A
- Gene Name
- COQ8A
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0051640|Atypical kinase COQ8A, mitochondrial MAAILGDTIMVAKGLVKLTQAAVETHLQHLGIGGELIMAARALQSTAVEQIGMFLGKVQG QDKHEEYFAENFGGPEGEFHFSVPHAAGASTDFSSASAPDQSAPPSLGHAHSEGPAPAYV ASGPFREAGFPGQASSPLGRANGRLFANPRDSFSAMGFQRRFFHQDQSPVGGLTAEDIEK ARQAKARPENKQHKQTLSEHARERKVPVTRIGRLANFGGLAVGLGFGALAEVAKKSLRSE DPSGKKAVLGSSPFLSEANAERIVRTLCKVRGAALKLGQMLSIQDDAFINPHLAKIFERV RQSADFMPLKQMMKTLNNDLGPNWRDKLEYFEERPFAAASIGQVHLARMKGGREVAMKIQ YPGVAQSINSDVNNLMAVLNMSNMLPEGLFPEHLIDVLRRELALECDYQREAACARKFRD LLKGHPFFYVPEIVDELCSPHVLTTELVSGFPLDQAEGLSQEIRNEICYNILVLCLRELF EFHFMQTDPNWSNFFYDPQQHKVALLDFGATREYDRSFTDLYIQIIRAAADRDRETVRAK SIEMKFLTGYEVKVMEDAHLDAILILGEAFASDEPFDFGTQSTTEKIHNLIPVMLRHRLV PPPEETYSLHRKMGGSFLICSKLKARFPCKAMFEEAYSNYCKRQAQQ
- Number of residues
- 647
- Molecular Weight
- 71949.52
- Theoretical pI
- Not Available
- GO Classification
- FunctionsADP binding / ATP binding / kinase activityProcessesphosphorylation / ubiquinone biosynthetic processComponentsintegral component of membrane / mitochondrion
- General Function
- Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration (PubMed:25498144, PubMed:21296186, PubMed:25540914, PubMed:27499294). Its substrate specificity is unclear: does not show any protein kinase activity (PubMed:25498144, PubMed:27499294). Probably acts as a small molecule kinase, possibly a lipid kinase that phosphorylates a prenyl lipid in the ubiquinone biosynthesis pathway, as suggested by its ability to bind coenzyme Q lipid intermediates (PubMed:25498144, PubMed:27499294). Shows an unusual selectivity for binding ADP over ATP (PubMed:25498144).
- Specific Function
- Adp binding
- Pfam Domain Function
- ABC1 (PF03109)
- Transmembrane Regions
- 214-230
- Cellular Location
- Mitochondrion
- Gene sequence
>lcl|BSEQ0051641|Atypical kinase COQ8A, mitochondrial (COQ8A) ATGGCTGCCATATTGGGAGACACCATCATGGTGGCTAAAGGCCTTGTCAAGCTGACCCAG GCGGCCGTGGAAACCCACCTGCAGCACTTGGGCATCGGAGGGGAGCTGATCATGGCGGCC AGGGCCCTGCAGTCCACGGCTGTGGAGCAGATTGGCATGTTCTTGGGGAAGGTGCAGGGT CAGGATAAACATGAAGAATATTTTGCTGAGAACTTCGGCGGCCCAGAAGGGGAGTTCCAC TTCTCAGTCCCGCATGCAGCCGGAGCCTCCACAGACTTCTCTTCAGCCTCCGCTCCCGAC CAGTCAGCGCCCCCATCCCTGGGTCATGCCCACAGCGAGGGCCCAGCTCCTGCCTACGTG GCCAGTGGACCCTTTAGAGAAGCCGGGTTCCCCGGCCAGGCCTCCTCCCCTCTGGGCAGG GCCAACGGGAGGCTCTTTGCAAACCCCAGAGACTCATTCTCTGCCATGGGCTTTCAGCGA AGGTTCTTCCACCAGGACCAATCCCCTGTTGGGGGCCTCACAGCCGAGGACATTGAGAAG GCCCGGCAGGCTAAGGCTCGCCCCGAGAACAAGCAGCACAAACAGACGCTCAGCGAGCAT GCCCGGGAGCGGAAGGTGCCTGTGACGAGGATTGGCCGGCTGGCCAACTTCGGAGGTCTG GCCGTGGGCCTGGGCTTCGGGGCACTGGCAGAGGTCGCCAAGAAGAGCCTGCGCTCCGAG GACCCCTCAGGGAAGAAGGCCGTGCTGGGTTCCAGTCCTTTCCTGTCCGAGGCCAATGCA GAGCGGATCGTGCGCACGCTCTGCAAGGTGCGTGGTGCGGCACTCAAGCTGGGCCAGATG CTGAGCATCCAGGATGATGCCTTTATCAACCCCCACCTGGCTAAGATCTTCGAGCGGGTG CGGCAGAGCGCGGACTTCATGCCACTGAAGCAGATGATGAAAACTCTCAACAACGACCTG GGCCCCAACTGGCGGGACAAGTTGGAATACTTCGAGGAGCGGCCCTTCGCCGCCGCATCC ATTGGGCAGGTGCACTTGGCCCGAATGAAGGGCGGCCGCGAGGTGGCCATGAAGATCCAG TACCCTGGCGTGGCCCAGAGCATCAACAGTGATGTCAACAACCTCATGGCCGTGTTGAAC ATGAGCAACATGCTTCCAGAAGGCCTGTTCCCCGAGCACCTGATCGACGTGCTGAGGCGG GAGCTGGCCCTGGAGTGTGACTACCAGCGAGAGGCCGCCTGTGCCCGCAAGTTCAGGGAC CTGCTGAAGGGCCACCCCTTCTTCTATGTGCCTGAGATTGTGGATGAGCTCTGCAGCCCA CATGTGCTGACCACAGAGCTGGTGTCTGGCTTCCCCCTGGACCAGGCCGAAGGGCTCAGC CAGGAGATTCGGAACGAGATCTGCTACAACATCCTGGTTCTGTGCCTGAGGGAGCTGTTC GAGTTCCACTTCATGCAAACAGACCCCAACTGGTCCAACTTCTTCTATGACCCCCAGCAG CACAAGGTGGCTCTTTTGGATTTTGGGGCAACGCGGGAATATGACAGATCCTTCACCGAC CTCTACATTCAGATCATCAGGGCTGCTGCCGACAGGGACAGGGAGACTGTGCGGGCGAAA TCCATAGAGATGAAGTTCCTCACCGGCTACGAGGTCAAGGTCATGGAAGACGCCCACTTG GATGCCATCCTCATCCTGGGGGAGGCCTTCGCCTCTGATGAGCCTTTTGATTTTGGCACT CAGAGCACCACCGAGAAGATCCACAACCTGATTCCCGTCATGCTGAGGCACCGTCTCGTC CCCCCACCCGAGGAAACCTACTCCCTGCACAGGAAGATGGGGGGCTCCTTCCTCATCTGC TCCAAGCTGAAGGCCCGCTTCCCCTGCAAGGCCATGTTCGAGGAGGCCTACAGCAACTAC TGCAAGAGGCAGGCCCAGCAGTAG
- Chromosome Location
- 1
- Locus
- 1q42.13
- External Identifiers
Resource Link UniProtKB ID Q8NI60 UniProtKB Entry Name COQ8A_HUMAN HGNC ID HGNC:16812 - General References
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