DNA-directed RNA polymerase subunit beta
Details
- Name
- DNA-directed RNA polymerase subunit beta
- Synonyms
- 2.7.7.6
- RNA polymerase subunit beta
- RNAP subunit beta
- Transcriptase subunit beta
- Gene Name
- rpoB
- Organism
- Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
- Amino acid sequence
>lcl|BSEQ0019408|DNA-directed RNA polymerase subunit beta MEIKRFGRIREVIPLPPLTEIQVESYRRALQADVPPEKRENVGIQAAFRETFPIEEEDKG KGGLVLDFLEYRLGEPPFPQDECREKDLTYQAPLYARLQLIHKDTGLIKEDEVFLGHIPL MTEDGSFIINGADRVIVSQIHRSPGVYFTPDPARPGRYIASIIPLPKRGPWIDLEVEPNG VVSMKVNKRKFPLVLLLRVLGYDQETLARELGAYGELVQGLMDESVFAMRPEEALIRLFT LLRPGDPPKRDKAVAYVYGLIADPRRYDLGEAGRYKAEEKLGIRLSGRTLARFEDGEFKD EVFLPTLRYLFALTAGVPGHEVDDIDHLGNRRIRTVGELMTDQFRVGLARLARGVRERML MGSEDSLTPAKLVNSRPLEAAIREFFSRSQLSQFKDETNPLSSLRHKRRISALGPGGLTR ERAGFDVRDVHRTHYGRICPVETPEGANIGLITSLAAYARVDELGFIRTPYRRVVGGVVT DEVVYMTATEEDRYTIAQANTPLEGNRIAAERVVARRKGEPVIVSPEEVEFMDVSPKQVF SVNTNLIPFLEHDDANRALMGSNMQTQAVPLIRAQAPVVMTGLEERVVRDSLAALYAEED GEVAKVDGNRIVVRYEDGRLVEYPLRRFYRSNQGTALDQRPRVVVGQRVRKGDLLADGPA SENGFLALGQNVLVAIMPFDGYNFEDAIVISEELLKRDFYTSIHIERYEIEARDTKLGPE RITRDIPHLSEAALRDLDEEGVVRIGAEVKPGDILVGRTSFKGESEPTPEERLLRSIFGE KARDVKDTSLRVPPGEGGIVVRTVRLRRGDPGVELKPGVREVVRVYVAQKRKLQVGDKLA NRHGNKGVVAKILPVEDMPHLPDGTPVDVILNPLGVPSRMNLGQILETHLGLAGYFLGQR YISPIFDGAKEPEIKELLAQAFEVYFGKRKGEGFGVDKREVEVLRRAEKLGLVTPGKTPE EQLKELFLQGKVVLYDGRTGEPIEGPIVVGQMFIMKLYHMVEDKMHARSTGPYSLITQQP LGGKAQFGGQRFGEMEVWALEAYGAAHTLQEMLTLKSDDIEGRNAAYEAIIKGEDVPEPS VPESFRVLVKELQALALDVQTLDEKDNPVDIFEGLASKR
- Number of residues
- 1119
- Molecular Weight
- 125263.41
- Theoretical pI
- 5.73
- GO Classification
- FunctionsDNA binding / DNA-directed RNA polymerase activity / ribonucleoside bindingProcessestranscription, DNA-templated
- General Function
- Ribonucleoside binding
- Specific Function
- DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasmic
- Gene sequence
>lcl|BSEQ0019409|DNA-directed RNA polymerase subunit beta (rpoB) ATGGAGATCAAGCGGTTCGGTCGCATCCGAGAGGTTATCCCCCTTCCACCCCTCACCGAG ATCCAGGTGGAGTCCTACCGCAGGGCCCTGCAGGCCGACGTCCCCCCGGAGAAGCGGGAG AACGTCGGCATCCAGGCGGCCTTCCGGGAGACCTTCCCCATTGAGGAGGAGGACAAGGGC AAGGGCGGTTTGGTGCTGGACTTCCTGGAGTACCGCCTGGGCGAGCCCCCCTTCCCCCAG GACGAGTGCCGGGAGAAGGACCTCACCTACCAGGCCCCCCTCTACGCCCGGCTCCAGCTC ATCCACAAGGACACGGGCCTCATCAAGGAGGACGAGGTCTTCCTGGGGCACATCCCCCTG ATGACCGAGGACGGCTCCTTCATCATCAACGGGGCCGACCGGGTCATCGTCTCCCAGATC CACCGCTCCCCCGGGGTCTACTTCACCCCCGACCCCGCCCGGCCCGGGCGCTACATCGCC AGCATCATCCCCCTGCCCAAGCGGGGCCCCTGGATTGACCTGGAGGTGGAGCCGAACGGC GTCGTCTCCATGAAGGTCAACAAGCGGAAGTTCCCCCTGGTCCTCCTCCTTCGGGTCCTG GGGTACGACCAGGAGACCCTGGCCCGGGAGCTTGGGGCCTACGGGGAGCTGGTCCAGGGC CTCATGGACGAGAGCGTCTTCGCCATGCGCCCCGAGGAGGCTCTGATCCGCCTCTTCACC CTCCTCCGCCCCGGGGACCCGCCCAAGCGGGACAAGGCCGTGGCCTACGTCTACGGCCTC ATCGCCGACCCCAGGCGGTACGACCTGGGCGAGGCCGGGCGGTACAAGGCGGAGGAGAAG CTGGGGATCCGCCTCTCGGGCCGCACCCTGGCCCGCTTTGAGGACGGGGAGTTCAAGGAC GAGGTCTTCCTCCCCACCCTCCGCTACCTCTTCGCCCTCACCGCCGGGGTCCCGGGCCAC GAGGTGGACGACATTGACCACCTGGGCAACCGCCGCATCCGCACCGTGGGGGAGCTCATG ACCGACCAGTTCCGGGTGGGGCTCGCCCGCCTCGCCCGGGGGGTGCGGGAGCGGATGCTC ATGGGCTCGGAGGACAGCCTCACCCCGGCCAAGCTGGTGAACAGCCGCCCCTTGGAGGCC GCCATCCGGGAGTTCTTCAGCCGCAGCCAGCTTTCCCAGTTCAAGGACGAGACCAACCCC CTCTCCTCCCTGCGCCACAAGCGGCGGATCTCCGCCCTGGGCCCGGGCGGCCTCACCCGG GAGCGGGCGGGGTTTGACGTGCGCGACGTCCACCGCACCCACTACGGGCGCATCTGCCCC GTGGAGACCCCCGAGGGCGCCAACATCGGCCTCATCACCTCCTTGGCGGCCTACGCCCGG GTGGACGAGCTGGGCTTCATCCGCACCCCCTACCGCCGGGTGGTGGGCGGGGTGGTCACC GACGAGGTGGTCTACATGACGGCCACCGAGGAGGACCGCTACACCATCGCCCAGGCCAAC ACCCCCCTGGAGGGGAACCGGATCGCGGCCGAGCGGGTGGTGGCCCGGAGGAAGGGGGAG CCCGTGATCGTGAGCCCGGAAGAGGTGGAGTTCATGGACGTCTCCCCCAAGCAGGTCTTC TCCGTGAACACCAACCTCATTCCCTTCCTGGAGCACGACGACGCCAACCGGGCCCTCATG GGCTCCAACATGCAGACCCAGGCCGTGCCCCTCATCCGGGCCCAGGCCCCCGTGGTGATG ACGGGCCTCGAGGAGCGGGTGGTGCGGGACTCCCTGGCCGCCCTCTACGCCGAGGAGGAC GGGGAGGTGGCCAAGGTGGACGGCAACCGCATCGTCGTGCGCTACGAGGACGGCCGCCTG GTGGAGTACCCCTTGCGCCGCTTCTACCGCTCCAACCAGGGTACGGCCCTGGACCAGCGC CCCCGGGTGGTGGTGGGGCAGCGGGTGCGCAAAGGGGACCTCCTCGCCGACGGCCCCGCC TCCGAGAACGGCTTCCTGGCCCTGGGGCAGAACGTCCTCGTGGCCATCATGCCCTTTGAC GGGTACAACTTTGAGGACGCCATCGTCATCAGCGAGGAGCTCCTCAAGCGGGACTTCTAC ACCTCCATCCACATTGAGCGCTACGAGATTGAGGCCCGGGACACCAAGCTTGGCCCCGAG CGGATCACCCGGGACATCCCCCACCTCTCCGAGGCCGCCCTAAGGGACCTGGACGAGGAG GGCGTGGTGCGCATCGGCGCCGAGGTGAAGCCCGGGGACATCCTCGTGGGGCGGACCAGC TTCAAGGGCGAGTCCGAGCCCACCCCCGAGGAGAGGCTCCTCCGCTCCATCTTCGGCGAG AAGGCCCGGGACGTGAAGGACACCTCCCTCCGGGTGCCGCCCGGCGAAGGGGGGATCGTG GTCCGCACCGTCCGGCTGCGGCGGGGCGACCCCGGGGTGGAGCTCAAGCCCGGGGTGCGG GAGGTGGTCCGGGTCTACGTGGCCCAGAAGCGCAAGCTCCAGGTGGGGGACAAGCTCGCC AACCGCCACGGGAACAAGGGGGTGGTGGCCAAGATCCTCCCCGTGGAGGACATGCCCCAC CTGCCCGACGGCACCCCCGTGGACGTGATCCTGAACCCCCTGGGCGTCCCCAGCCGGATG AACCTGGGGCAGATCCTGGAGACCCACCTGGGCCTCGCCGGGTACTTCCTGGGCCAGCGC TACATCTCCCCCATCTTTGACGGGGCCAAGGAGCCCGAGATCAAGGAGCTCCTCGCCCAG GCCTTTGAGGTCTACTTCGGCAAGCGCAAGGGCGAGGGCTTCGGCGTGGACAAGCGGGAG GTGGAGGTCCTCCGCCGGGCGGAGAAGCTCGGCCTCGTCACCCCGGGCAAGACCCCGGAG GAGCAGCTTAAGGAGCTCTTCCTCCAGGGCAAGGTGGTCCTCTACGACGGCCGCACGGGC GAGCCCATTGAGGGCCCCATCGTGGTGGGACAGATGTTCATCATGAAGCTCTACCACATG GTGGAGGACAAGATGCACGCCCGCTCCACGGGGCCCTACTCCCTCATCACCCAGCAGCCC CTGGGCGGGAAGGCCCAGTTCGGCGGCCAGCGCTTCGGGGAGATGGAGGTCTGGGCCCTC GAGGCCTATGGGGCGGCCCACACCCTCCAGGAGATGCTCACCCTTAAGTCCGACGACATT GAGGGCAGGAACGCCGCCTACGAGGCCATCATCAAGGGGGAGGACGTTCCCGAGCCCAGC GTCCCCGAGTCCTTCCGCGTGCTGGTGAAGGAGCTCCAGGCCTTGGCCTTGGACGTGCAG ACCCTGGACGAGAAGGACAACCCCGTGGACATCTTTGAGGGGTTGGCCTCCAAGCGGTGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q8RQE9 UniProtKB Entry Name RPOB_THET8 GenBank Gene ID AB083789 - General References
- Vassylyeva MN, Lee J, Sekine SI, Laptenko O, Kuramitsu S, Shibata T, Inoue Y, Borukhov S, Vassylyev DG, Yokoyama S: Purification, crystallization and initial crystallographic analysis of RNA polymerase holoenzyme from Thermus thermophilus. Acta Crystallogr D Biol Crystallogr. 2002 Sep;58(Pt 9):1497-500. Epub 2002 Aug 23. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB04788 Tagetitoxin experimental unknown Details DB08226 Myxopyronin B experimental unknown Details DB08266 Methyl [(1E,5R)-5-{3-[(2E,4E)-2,5-dimethyl-2,4-octadienoyl]-2,4-dioxo-3,4-dihydro-2H-pyran-6-yl}hexylidene]carbamate experimental unknown Details