Retinol dehydrogenase 11

Details

Name
Retinol dehydrogenase 11
Synonyms
  • 1.1.1.300
  • Androgen-regulated short-chain dehydrogenase/reductase 1
  • ARSDR1
  • HCV core-binding protein HCBP12
  • Prostate short-chain dehydrogenase/reductase 1
  • PSDR1
  • RalR1
  • Retinal reductase 1
  • SDR7C1
  • Short chain dehydrogenase/reductase family 7C member 1
Gene Name
RDH11
Organism
Humans
Amino acid sequence
>lcl|BSEQ0004558|Retinol dehydrogenase 11
MVELMFPLLLLLLPFLLYMAAPQIRKMLSSGVCTSTVQLPGKVVVVTGANTGIGKETAKE
LAQRGARVYLACRDVEKGELVAKEIQTTTGNQQVLVRKLDLSDTKSIRAFAKGFLAEEKH
LHVLINNAGVMMCPYSKTADGFEMHIGVNHLGHFLLTHLLLEKLKESAPSRIVNVSSLAH
HLGRIHFHNLQGEKFYNAGLAYCHSKLANILFTQELARRLKGSGVTTYSVHPGTVQSELV
RHSSFMRWMWWLFSFFIKTPQQGAQTSLHCALTEGLEILSGNHFSDCHVAWVSAQARNET
IARRLWDVSCDLLGLPID
Number of residues
318
Molecular Weight
35385.955
Theoretical pI
9.06
GO Classification
Functions
NADP-retinol dehydrogenase activity / retinol dehydrogenase activity
Processes
adaptation of rhodopsin mediated signaling / phototransduction, visible light / retinal metabolic process / retinoid metabolic process / retinol metabolic process
Components
endoplasmic reticulum membrane / integral component of membrane / intracellular / photoreceptor inner segment
General Function
Retinol dehydrogenase activity
Specific Function
Exhibits an oxidoreductive catalytic activity towards retinoids. Most efficient as an NADPH-dependent retinal reductase. Displays high activity towards 9-cis and all-trans-retinol. Also involved in the metabolism of short-chain aldehydes. No steroid dehydrogenase activity detected.
Pfam Domain Function
Transmembrane Regions
1-21
Cellular Location
Endoplasmic reticulum membrane
Gene sequence
>lcl|BSEQ0011671|Retinol dehydrogenase 11 (RDH11)
ATGGTTGAGCTCATGTTCCCGCTGTTGCTCCTCCTTCTGCCCTTCCTTCTGTATATGGCT
GCGCCCCAAATCAGGAAAATGCTGTCCAGTGGGGTGTGTACATCAACTGTTCAGCTTCCT
GGGAAAGTAGTTGTGGTCACAGGAGCTAATACAGGTATCGGGAAGGAGACAGCCAAAGAG
CTGGCTCAGAGAGGAGCTCGAGTATATTTAGCTTGCCGGGATGTGGAAAAGGGGGAATTG
GTGGCCAAAGAGATCCAGACCACGACAGGGAACCAGCAGGTGTTGGTGCGGAAACTGGAC
CTGTCTGATACTAAGTCTATTCGAGCTTTTGCTAAGGGCTTCTTAGCTGAGGAAAAGCAC
CTCCACGTTTTGATCAACAATGCAGGAGTGATGATGTGTCCGTACTCGAAGACAGCAGAT
GGCTTTGAGATGCACATAGGAGTCAACCACTTGGGCTCTGGCGTTACGACGTATTCTGTA
CACCCTGGCACAGTCCAATCTGAACTGGTTCGGCACTCATCTTTCATGAGATGGATGTGG
TGGCTTTTCTCCTTTTTCATCAAGACTCCTCAGCAGGGAGCCCAGACCAGCCTGCACTGT
GCCTTAACAGAAGGTCTTGAGATTCTAAGTGGGAATCATTTCAGTGACTGTCATGTGGCA
TGGGTCTCTGCCCAAGCTCGTAATGAGACTATAGCAAGGCGGCTGTGGGACGTCAGTTGT
GACCTGCTGGGCCTCCCAATAGACTAA
Chromosome Location
14
Locus
14q24.1
External Identifiers
ResourceLink
UniProtKB IDQ8TC12
UniProtKB Entry NameRDH11_HUMAN
GenBank Protein ID9622124
GenBank Gene IDAF167438
GenAtlas IDRDH11
HGNC IDHGNC:17964
General References
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00162Vitamin Aapproved, nutraceutical, vet_approvedunknownsubstrateDetails