Potassium voltage-gated channel subfamily V member 2

Details

Name

Potassium voltage-gated channel subfamily V member 2

Synonyms

• Voltage-gated potassium channel subunit Kv8.2

Gene Name

KCNV2

Organism

Humans

Amino acid sequence

>lcl|BSEQ0052257|Potassium voltage-gated channel subfamily V member 2
MLKQSERRRSWSYRPWNTTENEGSQHRRSICSLGARSGSQASIHGWTEGNYNYYIEEDED
GEEEDQWKDDLAEEDQQAGEVTTAKPEGPSDPPALLSTLNVNVGGHSYQLDYCELAGFPK
TRLGRLATSTSRSRQLSLCDDYEEQTDEYFFDRDPAVFQLVYNFYLSGVLLVLDGLCPRR
FLEELGYWGVRLKYTPRCCRICFEERRDELSERLKIQHELRAQAQVEEAEELFRDMRFYG
PQRRRLWNLMEKPFSSVAAKAIGVASSTFVLVSVVALALNTVEEMQQHSGQGEGGPDLRP
ILEHVEMLCMGFFTLEYLLRLASTPDLRRFARSALNLVDLVAILPLYLQLLLECFTGEGH
QRGQTVGSVGKVGQVLRVMRLMRIFRILKLARHSTGLRAFGFTLRQCYQQVGCLLLFIAM
GIFTFSAAVYSVEHDVPSTNFTTIPHSWWWAAVSISTVGYGDMYPETHLGRFFAFLCIAF
GIILNGMPISILYNKFSDYYSKLKAYEYTTIRRERGEVNFMQRARKKIAECLLGSNPQLT
PRQEN

Number of residues

545

Molecular Weight

62458.56

Theoretical pI

Not Available

GO Classification

Functions

voltage-gated potassium channel activity

Processes

potassium ion transmembrane transport / protein homooligomerization / regulation of ion transmembrane transport

Components

integral component of membrane / plasma membrane / voltage-gated potassium channel complex

General Function

Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values.

Specific Function

Voltage-gated potassium channel activity

Pfam Domain Function

• Ion_trans (PF00520)
• BTB_2 (PF02214)

Transmembrane Regions

156-176 262-282 337-357 375-395 411-431 472-492

Cellular Location

Cell membrane

Gene sequence

>lcl|BSEQ0052258|Potassium voltage-gated channel subfamily V member 2 (KCNV2)
ATGCTCAAACAGAGTGAGAGGAGACGGTCCTGGAGCTACAGGCCCTGGAACACGACGGAG
AATGAGGGCAGCCAACACCGCAGGAGCATTTGCTCCCTGGGTGCCCGTTCCGGCTCCCAG
GCCAGCATCCACGGCTGGACAGAGGGCAACTATAACTACTACATCGAGGAAGACGAAGAC
GGCGAGGAGGAGGACCAGTGGAAGGACGACCTGGCAGAAGAGGACCAGCAGGCAGGGGAG
GTCACCACCGCCAAGCCCGAGGGCCCCAGCGACCCTCCGGCCCTGCTGTCCACGCTGAAT
GTGAACGTGGGTGGCCACAGCTACCAGCTGGACTACTGCGAGCTGGCCGGCTTCCCCAAG
ACGCGCCTAGGTCGCCTGGCCACCTCCACCAGCCGCAGCCGCCAGCTAAGCCTGTGCGAC
GACTACGAGGAGCAGACAGACGAATACTTCTTCGACCGCGACCCGGCCGTCTTCCAGCTG
GTCTACAATTTCTACCTGTCCGGGGTGCTGCTGGTGCTCGACGGGCTGTGTCCGCGCCGC
TTCCTGGAGGAGCTGGGCTACTGGGGCGTGCGGCTCAAGTACACGCCACGCTGCTGCCGC
ATCTGCTTCGAGGAGCGGCGCGACGAGCTGAGCGAACGGCTCAAGATCCAGCACGAGCTG
CGCGCGCAGGCGCAGGTCGAGGAGGCGGAGGAACTCTTCCGCGACATGCGCTTCTACGGC
CCGCAGCGGCGCCGCCTCTGGAACCTCATGGAGAAGCCATTCTCCTCGGTGGCCGCCAAG
GCCATCGGGGTGGCCTCCAGCACCTTCGTGCTCGTCTCCGTGGTGGCGCTGGCGCTCAAC
ACCGTGGAGGAGATGCAGCAGCACTCGGGGCAGGGCGAGGGCGGCCCAGACCTGCGGCCC
ATCCTGGAGCACGTGGAGATGCTGTGCATGGGCTTCTTCACGCTCGAGTACCTGCTGCGC
CTAGCCTCCACGCCCGACCTGAGGCGCTTCGCGCGCAGCGCCCTCAACCTGGTGGACCTG
GTGGCCATCCTGCCGCTCTACCTTCAGCTGCTGCTCGAGTGCTTCACGGGCGAGGGCCAC
CAACGCGGCCAGACGGTGGGCAGCGTGGGTAAGGTGGGTCAGGTGTTGCGCGTCATGCGC
CTCATGCGCATCTTCCGCATCCTCAAGCTGGCGCGCCACTCCACCGGACTGCGTGCCTTC
GGCTTCACGCTGCGCCAGTGCTACCAGCAGGTGGGCTGCCTGCTGCTCTTCATCGCCATG
GGCATCTTCACTTTCTCTGCGGCTGTCTACTCTGTGGAGCACGATGTGCCCAGCACCAAC
TTCACTACCATCCCCCACTCCTGGTGGTGGGCCGCGGTGAGCATCTCCACCGTGGGCTAC
GGAGACATGTACCCAGAGACCCACCTGGGCAGGTTTTTTGCCTTCCTCTGCATTGCTTTT
GGGATCATTCTCAACGGGATGCCCATTTCCATCCTCTACAACAAGTTTTCTGATTACTAC
AGCAAGCTGAAGGCTTATGAGTATACCACCATACGCAGGGAGAGGGGAGAGGTGAACTTC
ATGCAGAGAGCCAGAAAGAAGATAGCTGAGTGTTTGCTTGGAAGCAACCCACAGCTCACC
CCAAGACAAGAGAATTAG

Chromosome Location

9

Locus

9p24.2

External Identifiers

Resource	Link
UniProtKB ID	Q8TDN2
UniProtKB Entry Name	KCNV2_HUMAN
HGNC ID	HGNC:19698

General References

1. Ottschytsch N, Raes A, Van Hoorick D, Snyders DJ: Obligatory heterotetramerization of three previously uncharacterized Kv channel alpha-subunits identified in the human genome. Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):7986-91. [Article]
2. Humphray SJ, Oliver K, Hunt AR, Plumb RW, Loveland JE, Howe KL, Andrews TD, Searle S, Hunt SE, Scott CE, Jones MC, Ainscough R, Almeida JP, Ambrose KD, Ashwell RI, Babbage AK, Babbage S, Bagguley CL, Bailey J, Banerjee R, Barker DJ, Barlow KF, Bates K, Beasley H, Beasley O, Bird CP, Bray-Allen S, Brown AJ, Brown JY, Burford D, Burrill W, Burton J, Carder C, Carter NP, Chapman JC, Chen Y, Clarke G, Clark SY, Clee CM, Clegg S, Collier RE, Corby N, Crosier M, Cummings AT, Davies J, Dhami P, Dunn M, Dutta I, Dyer LW, Earthrowl ME, Faulkner L, Fleming CJ, Frankish A, Frankland JA, French L, Fricker DG, Garner P, Garnett J, Ghori J, Gilbert JG, Glison C, Grafham DV, Gribble S, Griffiths C, Griffiths-Jones S, Grocock R, Guy J, Hall RE, Hammond S, Harley JL, Harrison ES, Hart EA, Heath PD, Henderson CD, Hopkins BL, Howard PJ, Howden PJ, Huckle E, Johnson C, Johnson D, Joy AA, Kay M, Keenan S, Kershaw JK, Kimberley AM, King A, Knights A, Laird GK, Langford C, Lawlor S, Leongamornlert DA, Leversha M, Lloyd C, Lloyd DM, Lovell J, Martin S, Mashreghi-Mohammadi M, Matthews L, McLaren S, McLay KE, McMurray A, Milne S, Nickerson T, Nisbett J, Nordsiek G, Pearce AV, Peck AI, Porter KM, Pandian R, Pelan S, Phillimore B, Povey S, Ramsey Y, Rand V, Scharfe M, Sehra HK, Shownkeen R, Sims SK, Skuce CD, Smith M, Steward CA, Swarbreck D, Sycamore N, Tester J, Thorpe A, Tracey A, Tromans A, Thomas DW, Wall M, Wallis JM, West AP, Whitehead SL, Willey DL, Williams SA, Wilming L, Wray PW, Young L, Ashurst JL, Coulson A, Blocker H, Durbin R, Sulston JE, Hubbard T, Jackson MJ, Bentley DR, Beck S, Rogers J, Dunham I: DNA sequence and analysis of human chromosome 9. Nature. 2004 May 27;429(6990):369-74. [Article]
3. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
4. Wu H, Cowing JA, Michaelides M, Wilkie SE, Jeffery G, Jenkins SA, Mester V, Bird AC, Robson AG, Holder GE, Moore AT, Hunt DM, Webster AR: Mutations in the gene KCNV2 encoding a voltage-gated potassium channel subunit cause "cone dystrophy with supernormal rod electroretinogram" in humans. Am J Hum Genet. 2006 Sep;79(3):574-9. Epub 2006 Jul 24. [Article]

Drug Relations

Drug Relations

DrugBank ID	Name	Drug group	Pharmacological action?	Actions	Details
DB00228	Enflurane	approved, investigational, vet_approved	unknown	inhibitoractivator	Details
DB01069	Promethazine	approved, investigational	unknown	inducer	Details
DB01110	Miconazole	approved, investigational, vet_approved	unknown	inhibitor	Details