Anthranilate phosphoribosyltransferase

Details

Name

Anthranilate phosphoribosyltransferase

Synonyms

• 2.4.2.18

Gene Name

trpD

Organism

Pectobacterium carotovorum

Amino acid sequence

>lcl|BSEQ0021992|Anthranilate phosphoribosyltransferase
MQATLIKPTIFTHQPILEKLFKSQSMTQEESHQLFAAIVRGELEDSQLAAALISMKMRGE
RPEEIAGAASALLADAQPFPRPDYDFADIVGTGGDGTNSINISTASAFVAASCGAKVAKH
GNRSVCQPLAGSCDLLQAFGIRLDMSAEDSRQALDDLNVCFLFAPQYHTGFRHAMPVRQQ
LKTRTIFNVLGPLINPARPPKALIGVYSPELVLPIAQALKVLGYKNAAVVHGGGMDEVAI
HTPTQVAELNNGEIESYQLSPQDFGLQSYSLNALQGGTPEENRDILARLLQGKGDAAHAR
QVAANVALLLKLFGQDNLRHNAQLALETIRSGTAFERVTALAARG

Number of residues

345

Molecular Weight

37017.84

Theoretical pI

6.6

GO Classification

Functions

anthranilate phosphoribosyltransferase activity / magnesium ion binding

Processes

tryptophan biosynthetic process

General Function

Magnesium ion binding

Specific Function

Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).

Pfam Domain Function

• Glycos_trans_3N (PF02885)
• Glycos_transf_3 (PF00591)

Transmembrane Regions

Not Available

Cellular Location

Not Available

Gene sequence

>lcl|BSEQ0004887|1038 bp
ATGCAAGCCACATTGATCAAACCAACTATTTTTACGCATCAGCCTATTTTAGAAAAACTG
TTCAAATCGCAGTCGATGACGCAAGAAGAAAGCCACCAGCTATTTGCCGCTATCGTGCGC
GGTGAGTTAGAAGACAGCCAACTGGCAGCGGCGCTGATTAGCATGAAAATGCGCGGTGAA
CGTCCTGAAGAAATTGCGGGGGCTGCCAGCGCCCTATTGGCTGATGCTCAACCGTTCCCG
CGCCCAGACTATGACTTTGCGGATATCGTAGGCACCGGCGGCGACGGTACGAACAGCATC
AACATCTCTACCGCGAGCGCTTTTGTCGCGGCCAGCTGCGGCGCTAAAGTGGCTAAACAT
GGCAACCGCAGCGTTTGCCAGCCGTTGGCAGGATCGTGTGATTTATTACAGGCCTTTGGC
ATTCGCTTAGACATGAGCGCCGAAGATTCACGCCAAGCGCTGGATGATTTAAATGTCTGT
TTCCTGTTTGCGCCGCAGTATCACACCGGTTTTCGCCACGCGATGCCGGTTCGCCAACAG
CTGAAAACCCGCACCATTTTTAACGTGCTCGGCCCACTGATTAACCCTGCGCGTCCACCT
AAGGCCCTGATCGGCGTTTACAGCCCTGAATTGGTGTTGCCGATTGCTCAGGCGCTAAAA
GTGTTGGGCTATAAGAATGCCGCGGTGGTTCACGGGGGTGGAATGGACGAAGTGGCTATT
CACACCCCGACGCAGGTGGCTGAGTTAAACAACGGTGAAATCGAAAGCTATCAGCTTTCT
CCGCAAGATTTTGGCTTACAGAGTTATTCGCTAAATGCGTTACAAGGCGGAACCCCAGAA
GAAAATCGTGACATTCTGGCGCGCTTATTACAAGGTAAAGGTGATGCAGCGCACGCTCGG
CAGGTCGCCGCTAACGTAGCTTTGCTGTTGAAATTGTTCGGTCAGGATAATCTGCGCCAC
AACGCGCAACTGGCACTGGAAACCATCAGAAGCGGGACAGCATTTGAGCGAGTGACCGCA
TTGGCAGCACGAGGCTGA

Chromosome Location

Not Available

Locus

Not Available

External Identifiers

Resource	Link
UniProtKB ID	Q8VP84
UniProtKB Entry Name	Q8VP84_PECCA
GenBank Gene ID	AY064465

General References

1. Kim C, Xuong NH, Edwards S, Madhusudan, Yee MC, Spraggon G, Mills SE: The crystal structure of anthranilate phosphoribosyltransferase from the enterobacterium Pectobacterium carotovorum. FEBS Lett. 2002 Jul 17;523(1-3):239-46. [Article]

Drug Relations

Drug Relations

DrugBank ID	Name	Drug group	Pharmacological action?	Actions	Details
DB01632	5-O-phosphono-alpha-D-ribofuranosyl diphosphate	approved, experimental, investigational	unknown		Details