Sodium-dependent phosphate transporter 1
Details
- Name
- Sodium-dependent phosphate transporter 1
- Synonyms
- Gibbon ape leukemia virus receptor 1
- GLVR-1
- GLVR1
- Leukemia virus receptor 1 homolog
- Phosphate transporter 1
- PiT-1
- PIT1
- Solute carrier family 20 member 1
- Gene Name
- SLC20A1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0022118|Sodium-dependent phosphate transporter 1 MATLITSTTAATAASGPLVDYLWMLILGFIIAFVLAFSVGANDVANSFGTAVGSGVVTLK QACILASIFETVGSVLLGAKVSETIRKGLIDVEMYNSTQGLLMAGSVSAMFGSAVWQLVA SFLKLPISGTHCIVGATIGFSLVAKGQEGVKWSELIKIVMSWFVSPLLSGIMSGILFFLV RAFILHKADPVPNGLRALPVFYACTVGINLFSIMYTGAPLLGFDKLPLWGTILISVGCAV FCALIVWFFVCPRMKRKIEREIKCSPSESPLMEKKNSLKEDHEETKLSVGDIENKHPVSE VGPATVPLQAVVEERTVSFKLGDLEEAPERERLPSVDLKEETSIDSTVNGAVQLPNGNLV QFSQAVSNQINSSGHYQYHTVHKDSGLYKELLHKLHLAKVGDCMGDSGDKPLRRNNSYTS YTMAICGMPLDSFRAKEGEQKGEEMEKLTWPNADSKKRIRMDSYTSYCNAVSDLHSASEI DMSVKAEMGLGDRKGSNGSLEEWYDQDKPEVSLLFQFLQILTACFGSFAHGGNDVSNAIG PLVALYLVYDTGDVSSKVATPIWLLLYGGVGICVGLWVWGRRVIQTMGKDLTPITPSSGF SIELASALTVVIASNIGLPISTTHCKVGSVVSVGWLRSKKAVDWRLFRNIFMAWFVTVPI SGVISAAIMAIFRYVILRM
- Number of residues
- 679
- Molecular Weight
- 73699.01
- Theoretical pI
- Not Available
- GO Classification
- Functionshigh-affinity inorganic phosphate / inorganic phosphate transmembrane transporter activity / receptor activity / signal transducer activity / sodiumProcessesion transport / phosphate ion transmembrane transport / phosphate-containing compound metabolic process / positive regulation of I-kappaB kinase/NF-kappaB signaling / signal transduction / transmembrane transport / transportComponentsintegral component of plasma membrane / membrane / plasma membrane
- General Function
- Not Available
- Specific Function
- Not Available
- Pfam Domain Function
- PHO4 (PF01384)
- Transmembrane Regions
- Not Available
- Cellular Location
- Membrane
- Gene sequence
>lcl|BSEQ0022119|Sodium-dependent phosphate transporter 1 (SLC20A1) ATGGCAACGCTGATTACCAGTACTACAGCTGCTACCGCCGCTTCTGGTCCTTTGGTGGAC TACCTATGGATGCTCATCCTGGGCTTCATTATTGCATTTGTCTTGGCATTCTCCGTGGGA GCCAATGATGTAGCAAATTCTTTTGGTACAGCTGTGGGCTCAGGTGTAGTGACCCTGAAG CAAGCCTGCATCCTAGCTAGCATCTTTGAAACAGTGGGCTCTGTCTTACTGGGGGCCAAA GTGAGCGAAACCATCCGGAAGGGCTTGATTGACGTGGAGATGTACAACTCGACTCAAGGG CTGCTGATGGCCGGCTCAGTCAGTGCTATGTTTGGTTCTGCTGTGTGGCAACTCGTGGCT TCGTTTTTGAAGCTCCCTATTTCTGGAACCCATTGTATTGTTGGTGCAACTATTGGTTTC TCCCTCGTGGCAAAGGGGCAGGAGGGTGTCAAGTGGTCTGAACTGATAAAAATTGTGATG TCTTGGTTCGTGTCCCCACTGCTTTCTGGAATTATGTCTGGAATTTTATTCTTCCTGGTT CGTGCATTCATCCTCCATAAGGCAGATCCAGTTCCTAATGGTTTGCGAGCTTTGCCAGTT TTCTATGCCTGCACAGTTGGAATAAACCTCTTTTCCATCATGTATACTGGAGCACCGTTG CTGGGCTTTGACAAACTTCCTCTGTGGGGTACCATCCTCATCTCGGTGGGATGTGCAGTT TTCTGTGCCCTTATCGTCTGGTTCTTTGTATGTCCCAGGATGAAGAGAAAAATTGAACGA GAAATAAAGTGTAGTCCTTCTGAAAGCCCCTTAATGGAAAAAAAGAATAGCTTGAAAGAA GACCATGAAGAAACAAAGTTGTCTGTTGGTGATATTGAAAACAAGCATCCTGTTTCTGAG GTAGGGCCTGCCACTGTGCCCCTCCAGGCTGTGGTGGAGGAGAGAACAGTCTCATTCAAA CTTGGAGATTTGGAGGAAGCTCCAGAGAGAGAGAGGCTTCCCAGCGTGGACTTGAAAGAG GAAACCAGCATAGATAGCACCGTGAATGGTGCAGTGCAGTTGCCTAATGGGAACCTTGTC CAGTTCAGTCAAGCCGTCAGCAACCAAATAAACTCCAGTGGCCACTACCAGTATCACACC GTGCATAAGGATTCCGGCCTGTACAAAGAGCTACTCCATAAATTACATCTTGCCAAGGTG GGAGATTGCATGGGAGACTCCGGTGACAAACCCTTAAGGCGCAATAATAGCTATACTTCC TATACCATGGCAATATGTGGCATGCCTCTGGATTCATTCCGTGCCAAAGAAGGTGAACAG AAGGGCGAAGAAATGGAGAAGCTGACATGGCCTAATGCAGACTCCAAGAAGCGAATTCGA ATGGACAGTTACACCAGTTACTGCAATGCTGTGTCTGACCTTCACTCAGCATCTGAGATA GACATGAGTGTCAAGGCAGAGATGGGTCTAGGTGACAGAAAAGGAAGTAATGGCTCTCTA GAAGAATGGTATGACCAGGATAAGCCTGAAGTCTCTCTCCTCTTCCAGTTCCTGCAGATC CTTACAGCCTGCTTTGGGTCATTCGCCCATGGTGGCAATGACGTAAGCAATGCCATTGGG CCTCTGGTTGCTTTATATTTGGTTTATGACACAGGAGATGTTTCTTCAAAAGTGGCAACA CCAATATGGCTTCTACTCTATGGTGGTGTTGGTATCTGTGTTGGTCTGTGGGTTTGGGGA AGAAGAGTTATCCAGACCATGGGGAAGGATCTGACACCGATCACACCCTCTAGTGGCTTC AGTATTGAACTGGCATCTGCCCTCACTGTGGTGATTGCATCAAATATTGGCCTTCCCATC AGTACAACACATTGTAAAGTGGGCTCTGTTGTGTCTGTTGGCTGGCTCCGGTCCAAGAAG GCTGTTGACTGGCGTCTCTTTCGTAACATTTTTATGGCCTGGTTTGTCACAGTCCCCATT TCTGGAGTTATCAGTGCTGCCATCATGGCAATCTTCAGATATGTCATCCTCAGAATGTGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q8WUM9 UniProtKB Entry Name S20A1_HUMAN HGNC ID HGNC:10946 - General References
- O'Hara B, Johann SV, Klinger HP, Blair DG, Rubinson H, Dunn KJ, Sass P, Vitek SM, Robins T: Characterization of a human gene conferring sensitivity to infection by gibbon ape leukemia virus. Cell Growth Differ. 1990 Mar;1(3):119-27. [Article]
- Hillier LW, Graves TA, Fulton RS, Fulton LA, Pepin KH, Minx P, Wagner-McPherson C, Layman D, Wylie K, Sekhon M, Becker MC, Fewell GA, Delehaunty KD, Miner TL, Nash WE, Kremitzki C, Oddy L, Du H, Sun H, Bradshaw-Cordum H, Ali J, Carter J, Cordes M, Harris A, Isak A, van Brunt A, Nguyen C, Du F, Courtney L, Kalicki J, Ozersky P, Abbott S, Armstrong J, Belter EA, Caruso L, Cedroni M, Cotton M, Davidson T, Desai A, Elliott G, Erb T, Fronick C, Gaige T, Haakenson W, Haglund K, Holmes A, Harkins R, Kim K, Kruchowski SS, Strong CM, Grewal N, Goyea E, Hou S, Levy A, Martinka S, Mead K, McLellan MD, Meyer R, Randall-Maher J, Tomlinson C, Dauphin-Kohlberg S, Kozlowicz-Reilly A, Shah N, Swearengen-Shahid S, Snider J, Strong JT, Thompson J, Yoakum M, Leonard S, Pearman C, Trani L, Radionenko M, Waligorski JE, Wang C, Rock SM, Tin-Wollam AM, Maupin R, Latreille P, Wendl MC, Yang SP, Pohl C, Wallis JW, Spieth J, Bieri TA, Berkowicz N, Nelson JO, Osborne J, Ding L, Meyer R, Sabo A, Shotland Y, Sinha P, Wohldmann PE, Cook LL, Hickenbotham MT, Eldred J, Williams D, Jones TA, She X, Ciccarelli FD, Izaurralde E, Taylor J, Schmutz J, Myers RM, Cox DR, Huang X, McPherson JD, Mardis ER, Clifton SW, Warren WC, Chinwalla AT, Eddy SR, Marra MA, Ovcharenko I, Furey TS, Miller W, Eichler EE, Bork P, Suyama M, Torrents D, Waterston RH, Wilson RK: Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Nature. 2005 Apr 7;434(7034):724-31. [Article]
- Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
- Palmer G, Manen D, Bonjour JP, Caverzasio J: Characterization of the human Glvr-1 phosphate transporter/retrovirus receptor gene and promoter region. Gene. 1999 Jan 8;226(1):25-33. [Article]
- Takeuchi Y, Vile RG, Simpson G, O'Hara B, Collins MK, Weiss RA: Feline leukemia virus subgroup B uses the same cell surface receptor as gibbon ape leukemia virus. J Virol. 1992 Feb;66(2):1219-22. [Article]
- Johann SV, Gibbons JJ, O'Hara B: GLVR1, a receptor for gibbon ape leukemia virus, is homologous to a phosphate permease of Neurospora crassa and is expressed at high levels in the brain and thymus. J Virol. 1992 Mar;66(3):1635-40. [Article]
- Johann SV, van Zeijl M, Cekleniak J, O'Hara B: Definition of a domain of GLVR1 which is necessary for infection by gibbon ape leukemia virus and which is highly polymorphic between species. J Virol. 1993 Nov;67(11):6733-6. [Article]
- Olah Z, Lehel C, Anderson WB, Eiden MV, Wilson CA: The cellular receptor for gibbon ape leukemia virus is a novel high affinity sodium-dependent phosphate transporter. J Biol Chem. 1994 Oct 14;269(41):25426-31. [Article]
- Miller DG, Miller AD: A family of retroviruses that utilize related phosphate transporters for cell entry. J Virol. 1994 Dec;68(12):8270-6. [Article]
- Kavanaugh MP, Miller DG, Zhang W, Law W, Kozak SL, Kabat D, Miller AD: Cell-surface receptors for gibbon ape leukemia virus and amphotropic murine retrovirus are inducible sodium-dependent phosphate symporters. Proc Natl Acad Sci U S A. 1994 Jul 19;91(15):7071-5. [Article]
- Jono S, McKee MD, Murry CE, Shioi A, Nishizawa Y, Mori K, Morii H, Giachelli CM: Phosphate regulation of vascular smooth muscle cell calcification. Circ Res. 2000 Sep 29;87(7):E10-7. [Article]
- Farrell KB, Russ JL, Murthy RK, Eiden MV: Reassessing the role of region A in Pit1-mediated viral entry. J Virol. 2002 Aug;76(15):7683-93. [Article]
- Cecil DL, Rose DM, Terkeltaub R, Liu-Bryan R: Role of interleukin-8 in PiT-1 expression and CXCR1-mediated inorganic phosphate uptake in chondrocytes. Arthritis Rheum. 2005 Jan;52(1):144-54. [Article]
- Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP: A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31. [Article]
- Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal Chem. 2009 Jun 1;81(11):4493-501. doi: 10.1021/ac9004309. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB09449 Sodium phosphate, monobasic approved no substrate Details DB11348 Calcium Phosphate approved no substrate Details DB14481 Calcium phosphate dihydrate approved no Details DB14502 Sodium phosphate, dibasic approved no Details DB14503 Sodium phosphate, monobasic, unspecified form approved no Details DB09436 Technetium Tc-99m succimer approved unknown substrate Details DB01250 Olsalazine approved unknown upregulator Details