Solute carrier family 12 member 5

Details

Name
Solute carrier family 12 member 5
Synonyms
  • Electroneutral potassium-chloride cotransporter 2
  • K-Cl cotransporter 2
  • Kcc2
  • Kiaa1176
  • mKCC2
  • Neuronal K-Cl cotransporter
Gene Name
Slc12a5
Organism
Mouse
Amino acid sequence
>lcl|BSEQ0052030|Solute carrier family 12 member 5
MSRRFTVTSLPPAASAASADPESRRHSVADPRRLPREDVKGDGNPKESSPFINSTDTEKG
REYDGRNMALFEEEMDTSPMVSSLLSGLANYTNLPQGSREHEEAENNEGGKKKPVQAPRM
GTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFICCSCTMLTAISMSAIATNG
VVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEILLAYLFPAMAIFKAE
DASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALVFLGCVILSILAIYAGVIKS
AFDPPNFPICLLGNRTLSRHGFDVCAKLAWEGNETVTTRLWGLFCSSRLLNATCDEYFTR
NNVTEIQGIPGAASGLIKENLWSSYLTKGVIVERRGMPSVGLADGTPVDMDHPYVFSDMT
SYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIATTSAVYISSVVLFGACI
EGVVLRDKFGEAVNGNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAISRDG
IVPFLQVFGHGKANGEPTWALLLTACICEIGILIASLDEVAPILSMFFLMCYMFVNLACA
VQTLLRTPNWRPRFRYYHWTLSFLGMSLCLALMFICSWYYALVAMLIAGLIYKYIEYRGA
EKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLVRVDQDQNVVHPQLLSLTSQ
LKAGKGLTIVGSVLEGTFLDNHPQAQRAEESIRRLMEAEKVKGFCQVVISSNLRDGVSHL
IQSGGLGGLQHNTVLVGWPRNWRQKEDHQTWRNFIELVRETTAGHLALLVTKNVSMFPGN
PERFSEGSIDVWWIVHDGGMLMLLPFLLRHHKVWRKCKMRIFTVAQMDDNSIQMKKDLTT
FLYHLRITAEVEVVEMHESDISAYTYEKTLVMEQRSQILKQMHLTKNEREREIQSITDES
RGSIRRKNPANPRLRLNVPEETACDNEEKPEEEVQLIHDQSAPSCPSSSPSPGEEPEGER
ETDPEVHLTWTKDKSVAEKNKGPSPVSSEGIKDFFSMKPEWENLNQSNVRRMHTAVRLNE
VIVNKSRDAKLVLLNMPGPPRNRNGDENYMEFLEVLTEQLDRVMLVRGGGREVITIYS
Number of residues
1138
Molecular Weight
126269.555
Theoretical pI
Not Available
GO Classification
Functions
ammonium transmembrane transporter activity / chloride transmembrane transporter activity / potassium / protein kinase binding
Processes
ammonium transport / cell volume homeostasis / cellular chloride ion homeostasis / cellular ion homeostasis / chemical synaptic transmission / chloride ion homeostasis / chloride transmembrane transport / chloride transport / dendritic spine development / hypotonic response / intracellular pH reduction / ion transport / learning / multicellular organism growth / potassium ion homeostasis / potassium ion import across plasma membrane / potassium ion transport / response to drug / thermosensory behavior
Components
dendrite membrane / dendritic shaft / integral component of membrane / integral component of plasma membrane / neuronal cell body / perikaryon / plasma membrane
General Function
Mediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl(-) homeostasis. As major extruder of intracellular chloride, it establishes the low neuronal Cl(-) levels required for chloride influx after binding of GABA-A and glycine to their receptors, with subsequent hyperpolarization and neuronal inhibition. Involved in the regulation of dendritic spine formation and maturation.
Specific Function
Ammonium transmembrane transporter activity
Pfam Domain Function
Transmembrane Regions
134-154 156-176 195-215 217-237 255-275 278-298 419-439 459-479 497-517 570-590 631-651 848-868
Cellular Location
Cell projection
Gene sequence
>lcl|BSEQ0052031|Solute carrier family 12 member 5 (Slc12a5)
ATGCTCAACAACCTGACGGACTGCGAGGACGGCGATGGGGGAGCCAACCCCGGTGATGGC
AACCCCAAAGAGAGCAGTCCCTTCATCAACAGCACGGACACGGAGAAGGGCAGAGAGTAC
GATGGCAGGAACATGGCCCTGTTTGAGGAGGAGATGGACACCAGCCCCATGGTATCCTCC
CTGCTCAGTGGGCTGGCCAACTACACCAACCTACCCCAGGGAAGTAGAGAGCATGAAGAA
GCAGAAAATAATGAGGGTGGAAAAAAGAAGCCGGTGCAGGCTCCTCGAATGGGCACCTTC
ATGGGTGTGTACCTGCCGTGCCTGCAGAACATCTTTGGTGTCATCCTCTTCCTGCGGCTC
ACGTGGGTGGTGGGCATCGCGGGCATCATGGAGTCCTTCTGTATGGTCTTCATTTGCTGC
TCCTGTACGATGCTCACAGCCATTTCCATGAGTGCAATCGCAACCAATGGTGTTGTGCCT
GCTGGTGGCTCGTACTACATGATTTCCAGGTCTCTGGGCCCGGAGTTTGGGGGCGCCGTG
GGCCTCTGCTTCTACCTGGGCACCACCTTTGCTGGGGCTATGTACATCCTTGGCACGATC
GAGATCCTGCTGGCTTATCTCTTCCCAGCTATGGCCATCTTCAAGGCAGAAGATGCCAGT
GGGGAGGCGGCCGCCATGCTGAACAACATGCGGGTGTATGGCACCTGTGTGCTCACCTGC
ATGGCCACCGTTGTCTTTGTGGGTGTCAAGTACGTCAACAAGTTTGCCTTGGTCTTCCTG
GGTTGCGTCATCCTGTCCATCCTGGCCATCTATGCAGGGGTCATCAAGTCTGCCTTCGAC
CCACCCAATTTCCCGATCTGCCTCCTGGGGAACCGCACGCTGTCTCGCCATGGCTTTGAT
GTCTGTGCCAAGCTGGCTTGGGAAGGAAATGAGACAGTGACCACACGGCTCTGGGGCCTT
TTCTGCTCCTCCCGCCTCCTCAATGCCACCTGTGATGAGTACTTCACCCGAAACAATGTC
ACAGAGATCCAGGGCATTCCTGGTGCTGCCAGTGGTCTCATCAAAGAGAACCTGTGGAGT
TCTTACCTGACCAAAGGGGTGATTGTCGAGAGGCGTGGGATGCCCTCTGTGGGCCTGGCA
GACGGTACCCCCGTAGACATGGACCACCCCTATGTCTTCAGTGATATGACCTCCTACTTC
ACCCTGCTCGTTGGTATCTACTTCCCCTCAGTCACAGGGATCATGGCTGGCTCAAACCGA
TCTGGAGACCTGCGGGATGCCCAGAAGTCTATCCCTACTGGAACTATCCTGGCCATTGCT
ACCACCTCTGCTGTCTACATCAGCTCTGTTGTTCTGTTTGGAGCCTGCATCGAGGGGGTC
GTCTTACGGGACAAGTTTGGGGAAGCTGTGAATGGCAACTTGGTGGTGGGCACCCTGGCC
TGGCCTTCTCCCTGGGTCATCGTCATAGGCTCTTTCTTCTCTACCTGTGGGGCTGGATTA
CAGAGCCTCACAGGGGCCCCACGTCTGCTGCAGGCCATCTCCCGGGATGGCATAGTGCCC
TTCCTGCAGGTCTTTGGCCATGGCAAAGCTAATGGAGAGCCAACCTGGGCGCTGCTGCTG
ACTGCCTGCATCTGTGAGATCGGCATCCTCATAGCCTCCCTGGATGAGGTCGCCCCTATA
CTTTCCATGTTCTTCCTAATGTGTTACATGTTTGTGAACTTGGCTTGTGCGGTGCAGACG
CTGCTGAGGACACCCAACTGGAGGCCACGATTTCGCTATTACCACTGGACTCTCTCCTTC
CTGGGCATGAGCCTCTGCCTGGCCCTCATGTTCATTTGCTCCTGGTACTACGCACTGGTG
GCCATGCTCATTGCCGGACTCATTTATAAGTACATCGAGTACCGGGGGGCGGAGAAGGAG
TGGGGGGATGGAATCCGAGGCCTGTCTCTCAGTGCAGCACGCTATGCTCTCTTGCGCCTG
GAGGAAGGACCTCCGCATACGAAGAACTGGAGGCCCCAGCTGCTGGTGCTGGTGCGTGTG
GACCAGGATCAGAACGTGGTGCATCCGCAGCTGCTCTCCCTGACCTCCCAGCTCAAGGCA
GGGAAGGGCCTGACCATTGTGGGCTCCGTCCTTGAGGGCACCTTTCTGGACAACCATCCA
CAGGCTCAGCGGGCAGAGGAGTCTATCAGGCGCCTGATGGAGGCTGAGAAGGTGAAGGGC
TTCTGCCAGGTAGTGATCTCCTCCAACCTGCGTGATGGTGTGTCCCACCTGATCCAGTCT
GGGGGCCTCGGGGGATTGCAACACAATACCGTGCTGGTGGGCTGGCCTCGCAACTGGAGG
CAGAAGGAGGATCATCAGACATGGAGGAACTTCATCGAACTGGTCCGGGAAACTACAGCC
GGCCACCTCGCCCTGCTGGTCACCAAGAATGTTTCCATGTTTCCCGGGAACCCTGAGCGC
TTCTCGGAGGGCAGCATTGACGTGTGGTGGATTGTGCACGACGGGGGCATGCTCATGCTG
CTGCCCTTCCTGCTGCGACACCACAAGGTCTGGAGGAAATGCAAAATGCGGATCTTCACC
GTGGCCCAGATGGACGATAACAGTATCCAGATGAAGAAGGACCTGACCACGTTTCTGTAC
CACTTACGCATTACTGCAGAGGTGGAGGTGGTGGAGATGCATGAGAGCGACATCTCGGCA
TACACCTACGAGAAGACATTAGTAATGGAGCAACGATCTCAGATCCTCAAACAGATGCAC
CTCACCAAGAACGAGCGGGAACGGGAGATCCAGAGCATCACAGACGAGTCTCGGGGCTCC
ATTCGGAGGAAGAATCCAGCCAACCCCCGGCTCCGCCTCAATGTTCCCGAAGAGACAGCG
TGTGACAATGAGGAGAAGCCAGAGGAGGAGGTGCAGCTGATCCATGACCAGAGTGCTCCC
AGCTGCCCTAGCAGCTCGCCATCTCCAGGGGAGGAGCCCGAGGGGGAGAGGGAGACAGAC
CCAGAGGTGCATCTTACCTGGACCAAGGATAAGTCAGTGGCAGAGAAGAATAAAGGCCCC
AGTCCCGTCTCCTCCGAGGGCATCAAGGACTTCTTCAGCATGAAGCCGGAGTGGGAAAAC
TTGAACCAGTCCAATGTACGGCGCATGCACACAGCTGTGCGGCTGAACGAGGTCATCGTG
AATAAATCTCGGGATGCCAAGCTAGTTTTGCTCAACATGCCCGGGCCTCCCCGCAACCGC
AATGGGGATGAAAACTACATGGAATTCTTGGAGGTCCTCACTGAGCAACTGGACCGGGTG
ATGCTGGTCCGCGGTGGCGGCCGAGAGGTCATCACCATCTACTCCTGA
Chromosome Location
2
Locus
2 H3
External Identifiers
ResourceLink
UniProtKB IDQ91V14
UniProtKB Entry NameS12A5_MOUSE
General References
  1. Ehringer MA, Thompson J, Conroy O, Xu Y, Yang F, Canniff J, Beeson M, Gordon L, Bennett B, Johnson TE, Sikela JM: High-throughput sequence identification of gene coding variants within alcohol-related QTLs. Mamm Genome. 2001 Aug;12(8):657-63. [Article]
  2. Okazaki N, Kikuno R, Ohara R, Inamoto S, Aizawa H, Yuasa S, Nakajima D, Nagase T, Ohara O, Koga H: Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2003 Feb 28;10(1):35-48. [Article]
  3. Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schonbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y: The transcriptional landscape of the mammalian genome. Science. 2005 Sep 2;309(5740):1559-63. [Article]
  4. Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP: Lineage-specific biology revealed by a finished genome assembly of the mouse. PLoS Biol. 2009 May 5;7(5):e1000112. doi: 10.1371/journal.pbio.1000112. Epub 2009 May 26. [Article]
  5. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  6. Haapa S, Suomalainen S, Eerikainen S, Airaksinen M, Paulin L, Savilahti H: An efficient DNA sequencing strategy based on the bacteriophage mu in vitro DNA transposition reaction. Genome Res. 1999 Mar;9(3):308-15. [Article]
  7. Uvarov P, Ludwig A, Markkanen M, Pruunsild P, Kaila K, Delpire E, Timmusk T, Rivera C, Airaksinen MS: A novel N-terminal isoform of the neuron-specific K-Cl cotransporter KCC2. J Biol Chem. 2007 Oct 19;282(42):30570-6. doi: 10.1074/jbc.M705095200. Epub 2007 Aug 22. [Article]
  8. Hubner CA, Stein V, Hermans-Borgmeyer I, Meyer T, Ballanyi K, Jentsch TJ: Disruption of KCC2 reveals an essential role of K-Cl cotransport already in early synaptic inhibition. Neuron. 2001 May;30(2):515-24. [Article]
  9. Zhao B, Wong AY, Murshid A, Bowie D, Presley JF, Bedford FK: Identification of a novel di-leucine motif mediating K(+)/Cl(-) cotransporter KCC2 constitutive endocytosis. Cell Signal. 2008 Oct;20(10):1769-79. doi: 10.1016/j.cellsig.2008.06.011. Epub 2008 Jun 24. [Article]
  10. Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP: A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89. doi: 10.1016/j.cell.2010.12.001. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB01216FinasterideapprovedunknownmodulatorDetails