Zinc transporter SLC39A7
Details
- Name
- Zinc transporter SLC39A7
- Synonyms
- Histidine-rich membrane protein Ke4
- HKE4
- Really interesting new gene 5 protein
- RING5
- Solute carrier family 39 member 7
- ZIP7
- Zrt-, Irt-like protein 7
- Gene Name
- SLC39A7
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0052349|Zinc transporter SLC39A7 MARGLGAPHWVAVGLLTWATLGLLVAGLGGHDDLHDDLQEDFHGHSHRHSHEDFHHGHSH AHGHGHTHESIWHGHTHDHDHGHSHEDLHHGHSHGYSHESLYHRGHGHDHEHSHGGYGES GAPGIKQDLDAVTLWAYALGATVLISAAPFFVLFLIPVESNSPRHRSLLQILLSFASGGL LGDAFLHLIPHALEPHSHHTLEQPGHGHSHSGQGPILSVGLWVLSGIVAFLVVEKFVRHV KGGHGHSHGHGHAHSHTRGSHGHGRQERSTKEKQSSEEEEKETRGVQKRRGGSTVPKDGP VRPQNAEEEKRGLDLRVSGYLNLAADLAHNFTDGLAIGASFRGGRGLGILTTMTVLLHEV PHEVGDFAILVQSGCSKKQAMRLQLLTAVGALAGTACALLTEGGAVGSEIAGGAGPGWVL PFTAGGFIYVATVSVLPELLREASPLQSLLEVLGLLGGVIMMVLIAHLE
- Number of residues
- 469
- Molecular Weight
- 50117.95
- Theoretical pI
- Not Available
- GO Classification
- Functionszinc ion transmembrane transporter activityProcessescellular zinc ion homeostasis / zinc ion transmembrane transportComponentscell / endoplasmic reticulum / endoplasmic reticulum membrane / Golgi apparatus / integral component of membrane / membrane / nucleoplasm
- General Function
- Zinc transporter, that transports Zn(2+) from the endoplasmic reticulum/Golgi apparatus to the cytosol. Transport is stimulated by growth factors, such as EGF, and Ca(2+), as well as by exogenous Zn(2+).
- Specific Function
- Zinc ion transmembrane transporter activity
- Pfam Domain Function
- Zip (PF02535)
- Transmembrane Regions
- 10-30 138-158 169-189 214-234 381-401 417-436
- Cellular Location
- Endoplasmic reticulum membrane
- Gene sequence
>lcl|BSEQ0052350|Zinc transporter SLC39A7 (SLC39A7) ATGGCCAGAGGCCTGGGGGCCCCCCACTGGGTGGCCGTGGGACTGCTGACCTGGGCGACC TTGGGGCTTCTGGTGGCTGGACTCGGGGGTCATGACGACCTGCACGACGATCTGCAAGAG GACTTCCATGGCCACAGCCACAGGCACTCACATGAAGATTTCCACCATGGCCACAGCCAT GCCCATGGCCATGGCCACACTCACGAGAGCATCTGGCATGGACATACCCACGATCACGAC CATGGACATTCACATGAGGATTTACACCATGGCCATAGCCATGGCTACTCCCATGAGAGC CTCTACCACAGAGGACATGGACATGACCATGAGCATAGCCATGGAGGCTATGGGGAGTCT GGGGCTCCAGGCATCAAGCAGGACCTGGATGCTGTCACTCTCTGGGCTTATGCACTGGGG GCCACAGTGCTGATCTCAGCAGCTCCATTTTTTGTCCTCTTCCTTATCCCCGTGGAGTCG AACTCTCCCCGGCATCGCTCTCTACTTCAGATCTTGCTCAGTTTTGCTTCCGGTGGGCTC CTGGGAGATGCTTTCCTGCACCTCATTCCTCATGCTCTTGAACCTCATTCTCACCACACT CTGGAGCAACCCGGACATGGACACTCCCACAGTGGCCAGGGCCCCATTCTGTCTGTGGGA CTGTGGGTTCTCAGTGGAATTGTTGCCTTTCTTGTCGTGGAGAAATTTGTGAGACATGTG AAAGGAGGACATGGTCACAGTCATGGACATGGACACGCTCACAGTCATACACGTGGAAGT CATGGACATGGAAGACAAGAGCGTTCTACCAAGGAGAAGCAGAGCTCAGAGGAAGAAGAA AAGGAAACAAGAGGGGTTCAGAAGAGGCGAGGAGGGAGCACAGTACCCAAAGATGGGCCA GTGAGACCTCAGAACGCTGAAGAAGAAAAAAGAGGCTTAGACCTGCGTGTGTCGGGGTAC CTGAATCTGGCTGCTGACTTGGCACACAACTTCACTGATGGTCTGGCCATTGGGGCTTCC TTTCGAGGGGGCCGGGGACTAGGGATCCTGACCACAATGACTGTCCTGCTACATGAAGTG CCCCACGAGGTCGGAGACTTTGCCATCTTGGTCCAGTCTGGCTGCAGCAAAAAGCAGGCG ATGCGTCTGCAACTACTGACAGCAGTAGGGGCACTGGCAGGCACAGCCTGTGCCCTTCTC ACTGAAGGAGGAGCAGTGGGCAGTGAAATTGCAGGTGGTGCAGGTCCTGGCTGGGTCCTG CCATTTACTGCAGGTGGCTTTATCTACGTAGCAACAGTGTCTGTGTTGCCCGAGCTGCTG AGGGAGGCATCACCATTGCAATCACTTCTGGAGGTGCTGGGGCTGCTGGGGGGAGTTATC ATGATGGTGCTGATTGCCCACCTTGAGTGA
- Chromosome Location
- 6
- Locus
- 6p21.32
- External Identifiers
Resource Link UniProtKB ID Q92504 UniProtKB Entry Name S39A7_HUMAN HGNC ID HGNC:4927 - General References
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- Taylor KM, Morgan HE, Johnson A, Nicholson RI: Structure-function analysis of HKE4, a member of the new LIV-1 subfamily of zinc transporters. Biochem J. 2004 Jan 1;377(Pt 1):131-9. doi: 10.1042/BJ20031183. [Article]
- Huang L, Kirschke CP, Zhang Y, Yu YY: The ZIP7 gene (Slc39a7) encodes a zinc transporter involved in zinc homeostasis of the Golgi apparatus. J Biol Chem. 2005 Apr 15;280(15):15456-63. doi: 10.1074/jbc.M412188200. Epub 2005 Feb 10. [Article]
- Zahedi RP, Lewandrowski U, Wiesner J, Wortelkamp S, Moebius J, Schutz C, Walter U, Gambaryan S, Sickmann A: Phosphoproteome of resting human platelets. J Proteome Res. 2008 Feb;7(2):526-34. Epub 2007 Dec 19. [Article]
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