Geranylgeranyl transferase type-2 subunit alpha
Details
- Name
- Geranylgeranyl transferase type-2 subunit alpha
- Synonyms
- 2.5.1.60
- Geranylgeranyl transferase type II subunit alpha
- Rab geranyl-geranyltransferase subunit alpha
- Rab geranylgeranyltransferase subunit alpha
- Rab GG transferase alpha
- Rab GGTase alpha
- Gene Name
- RABGGTA
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0012835|Geranylgeranyl transferase type-2 subunit alpha MHGRLKVKTSEEQAEAKRLEREQKLKLYQSATQAVFQKRQAGELDESVLELTSQILGANP DFATLWNCRREVLQQLETQKSPEELAALVKAELGFLESCLRVNPKSYGTWHHRCWLLGRL PEPNWTRELELCARFLEVDERNFHCWDYRRFVATQAAVPPAEELAFTDSLITRNFSNYSS WHYRSCLLPQLHPQPDSGPQGRLPEDVLLKELELVQNAFFTDPNDQSAWFYHRWLLGRAD PQDALRCLHVSRDEACLTVSFSRPLLVGSRMEILLLMVDDSPLIVEWRTPDGRNRPSHVW LCDLPAASLNDQLPQHTFRVIWTAGDVQKECVLLKGRQEGWCRDSTTDEQLFRCELSVEK STVLQSELESCKELQELEPENKWCLLTIILLMRALDPLLYEKETLQYFQTLKAVDPMRAT YLDDLRSKFLLENSVLKMEYAEVRVLHLAHKDLTVLCHLEQLLLVTHLDLSHNRLRTLPP ALAALRCLEVLQASDNAIESLDGVTNLPRLQELLLCNNRLQQPAVLQPLASCPRLVLLNL QGNPLCQAVGILEQLAELLPSVSSVLT
- Number of residues
- 567
- Molecular Weight
- 65071.06
- Theoretical pI
- 5.41
- GO Classification
- FunctionsRab geranylgeranyltransferase activity / Rab GTPase binding / zinc ion bindingProcessescellular protein modification process / protein geranylgeranylation / visual perceptionComponentsRab-protein geranylgeranyltransferase complex
- General Function
- Zinc ion binding
- Specific Function
- Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0012836|Geranylgeranyl transferase type-2 subunit alpha (RABGGTA) ATGCACGGACGCCTGAAGGTGAAGACGTCAGAAGAGCAGGCGGAGGCCAAAAGGCTAGAG CGAGAGCAGAAGCTGAAGCTATACCAGTCAGCCACCCAGGCCGTATTCCAGAAGCGCCAG GCTGGTGAGCTGGATGAGTCCGTGCTGGAACTGACAAGCCAGATTCTGGGAGCCAACCCT GATTTTGCCACCCTCTGGAACTGCCGACGAGAGGTGCTCCAGCAGCTGGAGACTCAGAAG TCTCCTGAAGAGTTGGCTGCTCTGGTGAAGGCAGAACTGGGCTTCCTGGAGAGCTGCCTG CGGGTGAACCCCAAGTCTTATGGTACCTGGCACCACCGATGCTGGCTGCTAGGCCGCCTG CCTGAGCCCAACTGGACCCGAGAGCTGGAGCTCTGTGCCCGTTTCCTGGAGGTGGATGAG CGGAACTTTCACTGCTGGGACTATCGGCGGTTTGTGGCCACACAGGCAGCCGTGCCCCCT GCAGAAGAGCTAGCCTTCACTGACAGCCTCATCACCCGAAACTTCTCCAACTACTCTTCC TGGCATTACCGCTCCTGTCTCTTGCCCCAGCTGCACCCCCAGCCGGATTCTGGACCACAG GGGCGCCTCCCTGAGGATGTGCTGCTCAAAGAGCTGGAGCTGGTGCAGAATGCCTTCTTC ACTGACCCCAATGACCAGAGTGCCTGGTTTTATCACCGTTGGCTCCTAGGCCGAGCTGAC CCCCAGGATGCACTGCGCTGCCTGCATGTGAGCCGGGACGAGGCCTGTCTGACTGTCTCC TTCTCTCGGCCCCTCTTAGTGGGCTCCAGGATGGAGATCTTGCTGCTCATGGTTGATGAT TCTCCCCTGATTGTGGAGTGGAGGACCCCAGATGGCAGGAACCGGCCCAGCCATGTCTGG CTCTGTGACCTGCCTGCTGCCTCCCTCAACGACCAGTTGCCCCAACATACATTTCGCGTC ATTTGGACAGCAGGCGATGTCCAGAAAGAATGCGTGCTTTTAAAAGGCCGCCAGGAGGGC TGGTGCCGGGACTCCACGACAGACGAGCAGCTATTCAGGTGTGAGCTGTCAGTGGAGAAG TCCACAGTGCTGCAGTCTGAGCTGGAATCCTGTAAGGAGCTGCAGGAGCTGGAGCCTGAG AATAAATGGTGCCTGCTTACCATCATCCTGCTGATGCGGGCACTGGACCCCCTGCTGTAT GAGAAGGAGACCCTGCAGTACTTCCAGACCCTCAAGGCCGTGGACCCCATGCGGGCAACG TATCTGGATGACCTGCGCAGCAAGTTCTTGCTGGAGAATAGCGTGCTCAAGATGGAGTAT GCCGAGGTGCGTGTGCTGCACCTGGCTCACAAGGATCTGACAGTGCTCTGCCATCTGGAA CAGCTGCTCTTGGTCACCCATCTTGACTTGTCACACAATCGCCTCCGAACCCTGCCACCT GCACTGGCTGCCCTGCGCTGCCTTGAGGTGCTGCAGGCCAGTGATAATGCCATAGAGTCC CTGGACGGCGTCACCAACCTACCCCGGCTGCAGGAGCTGCTACTGTGCAACAACCGCCTC CAGCAGCCTGCAGTGCTCCAGCCTCTTGCCTCCTGCCCCAGGCTGGTCCTCCTCAACCTG CAGGGTAACCCGCTGTGCCAAGCGGTGGGCATCTTGGAGCAACTGGCTGAACTGCTGCCT TCAGTTAGCAGCGTCCTCACCTAA
- Chromosome Location
- 14
- Locus
- 14q11.2
- External Identifiers
Resource Link UniProtKB ID Q92696 UniProtKB Entry Name PGTA_HUMAN GenBank Protein ID 2950170 GenBank Gene ID Y08200 HGNC ID HGNC:9795 - General References
- van Bokhoven H, Rawson RB, Merkx GF, Cremers FP, Seabra MC: cDNA cloning and chromosomal localization of the genes encoding the alpha- and beta-subunits of human Rab geranylgeranyl transferase: the 3' end of the alpha-subunit gene overlaps with the transglutaminase 1 gene promoter. Genomics. 1996 Dec 1;38(2):133-40. [Article]
- Song HJ, Rossi A, Ceci R, Kim IG, Anzano MA, Jang SI, De Laurenzi V, Steinert PM: The genes encoding geranylgeranyl transferase alpha-subunit and transglutaminase 1 are very closely linked but not functionally related in terminally differentiating keratinocytes. Biochem Biophys Res Commun. 1997 Jun 9;235(1):10-4. [Article]
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- Farnsworth CC, Seabra MC, Ericsson LH, Gelb MH, Glomset JA: Rab geranylgeranyl transferase catalyzes the geranylgeranylation of adjacent cysteines in the small GTPases Rab1A, Rab3A, and Rab5A. Proc Natl Acad Sci U S A. 1994 Dec 6;91(25):11963-7. [Article]
- Baron RA, Seabra MC: Rab geranylgeranylation occurs preferentially via the pre-formed REP-RGGT complex and is regulated by geranylgeranyl pyrophosphate. Biochem J. 2008 Oct 1;415(1):67-75. doi: 10.1042/BJ20080662. [Article]
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