Geranylgeranyl transferase type-2 subunit alpha

Details

Name
Geranylgeranyl transferase type-2 subunit alpha
Synonyms
  • 2.5.1.60
  • Geranylgeranyl transferase type II subunit alpha
  • Rab geranyl-geranyltransferase subunit alpha
  • Rab geranylgeranyltransferase subunit alpha
  • Rab GG transferase alpha
  • Rab GGTase alpha
Gene Name
RABGGTA
Organism
Humans
Amino acid sequence
>lcl|BSEQ0012835|Geranylgeranyl transferase type-2 subunit alpha
MHGRLKVKTSEEQAEAKRLEREQKLKLYQSATQAVFQKRQAGELDESVLELTSQILGANP
DFATLWNCRREVLQQLETQKSPEELAALVKAELGFLESCLRVNPKSYGTWHHRCWLLGRL
PEPNWTRELELCARFLEVDERNFHCWDYRRFVATQAAVPPAEELAFTDSLITRNFSNYSS
WHYRSCLLPQLHPQPDSGPQGRLPEDVLLKELELVQNAFFTDPNDQSAWFYHRWLLGRAD
PQDALRCLHVSRDEACLTVSFSRPLLVGSRMEILLLMVDDSPLIVEWRTPDGRNRPSHVW
LCDLPAASLNDQLPQHTFRVIWTAGDVQKECVLLKGRQEGWCRDSTTDEQLFRCELSVEK
STVLQSELESCKELQELEPENKWCLLTIILLMRALDPLLYEKETLQYFQTLKAVDPMRAT
YLDDLRSKFLLENSVLKMEYAEVRVLHLAHKDLTVLCHLEQLLLVTHLDLSHNRLRTLPP
ALAALRCLEVLQASDNAIESLDGVTNLPRLQELLLCNNRLQQPAVLQPLASCPRLVLLNL
QGNPLCQAVGILEQLAELLPSVSSVLT
Number of residues
567
Molecular Weight
65071.06
Theoretical pI
5.41
GO Classification
Functions
Rab geranylgeranyltransferase activity / Rab GTPase binding / zinc ion binding
Processes
cellular protein modification process / protein geranylgeranylation / visual perception
Components
Rab-protein geranylgeranyltransferase complex
General Function
Zinc ion binding
Specific Function
Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0012836|Geranylgeranyl transferase type-2 subunit alpha (RABGGTA)
ATGCACGGACGCCTGAAGGTGAAGACGTCAGAAGAGCAGGCGGAGGCCAAAAGGCTAGAG
CGAGAGCAGAAGCTGAAGCTATACCAGTCAGCCACCCAGGCCGTATTCCAGAAGCGCCAG
GCTGGTGAGCTGGATGAGTCCGTGCTGGAACTGACAAGCCAGATTCTGGGAGCCAACCCT
GATTTTGCCACCCTCTGGAACTGCCGACGAGAGGTGCTCCAGCAGCTGGAGACTCAGAAG
TCTCCTGAAGAGTTGGCTGCTCTGGTGAAGGCAGAACTGGGCTTCCTGGAGAGCTGCCTG
CGGGTGAACCCCAAGTCTTATGGTACCTGGCACCACCGATGCTGGCTGCTAGGCCGCCTG
CCTGAGCCCAACTGGACCCGAGAGCTGGAGCTCTGTGCCCGTTTCCTGGAGGTGGATGAG
CGGAACTTTCACTGCTGGGACTATCGGCGGTTTGTGGCCACACAGGCAGCCGTGCCCCCT
GCAGAAGAGCTAGCCTTCACTGACAGCCTCATCACCCGAAACTTCTCCAACTACTCTTCC
TGGCATTACCGCTCCTGTCTCTTGCCCCAGCTGCACCCCCAGCCGGATTCTGGACCACAG
GGGCGCCTCCCTGAGGATGTGCTGCTCAAAGAGCTGGAGCTGGTGCAGAATGCCTTCTTC
ACTGACCCCAATGACCAGAGTGCCTGGTTTTATCACCGTTGGCTCCTAGGCCGAGCTGAC
CCCCAGGATGCACTGCGCTGCCTGCATGTGAGCCGGGACGAGGCCTGTCTGACTGTCTCC
TTCTCTCGGCCCCTCTTAGTGGGCTCCAGGATGGAGATCTTGCTGCTCATGGTTGATGAT
TCTCCCCTGATTGTGGAGTGGAGGACCCCAGATGGCAGGAACCGGCCCAGCCATGTCTGG
CTCTGTGACCTGCCTGCTGCCTCCCTCAACGACCAGTTGCCCCAACATACATTTCGCGTC
ATTTGGACAGCAGGCGATGTCCAGAAAGAATGCGTGCTTTTAAAAGGCCGCCAGGAGGGC
TGGTGCCGGGACTCCACGACAGACGAGCAGCTATTCAGGTGTGAGCTGTCAGTGGAGAAG
TCCACAGTGCTGCAGTCTGAGCTGGAATCCTGTAAGGAGCTGCAGGAGCTGGAGCCTGAG
AATAAATGGTGCCTGCTTACCATCATCCTGCTGATGCGGGCACTGGACCCCCTGCTGTAT
GAGAAGGAGACCCTGCAGTACTTCCAGACCCTCAAGGCCGTGGACCCCATGCGGGCAACG
TATCTGGATGACCTGCGCAGCAAGTTCTTGCTGGAGAATAGCGTGCTCAAGATGGAGTAT
GCCGAGGTGCGTGTGCTGCACCTGGCTCACAAGGATCTGACAGTGCTCTGCCATCTGGAA
CAGCTGCTCTTGGTCACCCATCTTGACTTGTCACACAATCGCCTCCGAACCCTGCCACCT
GCACTGGCTGCCCTGCGCTGCCTTGAGGTGCTGCAGGCCAGTGATAATGCCATAGAGTCC
CTGGACGGCGTCACCAACCTACCCCGGCTGCAGGAGCTGCTACTGTGCAACAACCGCCTC
CAGCAGCCTGCAGTGCTCCAGCCTCTTGCCTCCTGCCCCAGGCTGGTCCTCCTCAACCTG
CAGGGTAACCCGCTGTGCCAAGCGGTGGGCATCTTGGAGCAACTGGCTGAACTGCTGCCT
TCAGTTAGCAGCGTCCTCACCTAA
Chromosome Location
14
Locus
14q11.2
External Identifiers
ResourceLink
UniProtKB IDQ92696
UniProtKB Entry NamePGTA_HUMAN
GenBank Protein ID2950170
GenBank Gene IDY08200
HGNC IDHGNC:9795
General References
  1. van Bokhoven H, Rawson RB, Merkx GF, Cremers FP, Seabra MC: cDNA cloning and chromosomal localization of the genes encoding the alpha- and beta-subunits of human Rab geranylgeranyl transferase: the 3' end of the alpha-subunit gene overlaps with the transglutaminase 1 gene promoter. Genomics. 1996 Dec 1;38(2):133-40. [Article]
  2. Song HJ, Rossi A, Ceci R, Kim IG, Anzano MA, Jang SI, De Laurenzi V, Steinert PM: The genes encoding geranylgeranyl transferase alpha-subunit and transglutaminase 1 are very closely linked but not functionally related in terminally differentiating keratinocytes. Biochem Biophys Res Commun. 1997 Jun 9;235(1):10-4. [Article]
  3. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
  4. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  5. Farnsworth CC, Seabra MC, Ericsson LH, Gelb MH, Glomset JA: Rab geranylgeranyl transferase catalyzes the geranylgeranylation of adjacent cysteines in the small GTPases Rab1A, Rab3A, and Rab5A. Proc Natl Acad Sci U S A. 1994 Dec 6;91(25):11963-7. [Article]
  6. Baron RA, Seabra MC: Rab geranylgeranylation occurs preferentially via the pre-formed REP-RGGT complex and is regulated by geranylgeranyl pyrophosphate. Biochem J. 2008 Oct 1;415(1):67-75. doi: 10.1042/BJ20080662. [Article]
  7. Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Burckstummer T, Bennett KL, Superti-Furga G, Colinge J: Initial characterization of the human central proteome. BMC Syst Biol. 2011 Jan 26;5:17. doi: 10.1186/1752-0509-5-17. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB04464N-FormylmethionineexperimentalunknownDetails
DB07780Farnesyl diphosphateexperimentalunknownDetails
DB07841Geranylgeranyl diphosphateexperimentalunknownDetails