Sodium-coupled neutral amino acid transporter 4
Details
- Name
- Sodium-coupled neutral amino acid transporter 4
- Synonyms
- Amino acid transporter A3
- ATA3
- Na(+)-coupled neutral amino acid transporter 4
- NAT3
- SNAT4
- Solute carrier family 38 member 4
- System A amino acid transporter 3
- System N amino acid transporter 3
- Gene Name
- SLC38A4
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0052483|Sodium-coupled neutral amino acid transporter 4 MDPMELRNVNIEPDDESSSGESAPDSYIGIGNSEKAAMSSQFANEDTESQKFLTNGFLGK KKLADYADEHHPGTTSFGMSSFNLSNAIMGSGILGLSYAMANTGIILFIIMLLAVAILSL YSVHLLLKTAKEGGSLIYEKLGEKAFGWPGKIGAFVSITMQNIGAMSSYLFIIKYELPEV IRAFMGLEENTGEWYLNGNYLIIFVSVGIILPLSLLKNLGYLGYTSGFSLTCMVFFVSVV IYKKFQIPCPLPVLDHSVGNLSFNNTLPMHVVMLPNNSESSDVNFMMDYTHRNPAGLDEN QAKGSLHDSGVEYEAHSDDKCEPKYFVFNSRTAYAIPILVFAFVCHPEVLPIYSELKDRS RRKMQTVSNISITGMLVMYLLAALFGYLTFYGEVEDELLHAYSKVYTLDIPLLMVRLAVL VAVTLTVPIVLFPIRTSVITLLFPKRPFSWIRHFLIAAVLIALNNVLVILVPTIKYIFGF IGASSATMLIFILPAVFYLKLVKKETFRSPQKVGALIFLVVGIFFMIGSMALIIIDWIYD PPNSKHH
- Number of residues
- 547
- Molecular Weight
- 60763.6
- Theoretical pI
- Not Available
- GO Classification
- Functionsamino acid transmembrane transporter activity / symporter activityProcessesamino acid transmembrane transport / amino acid transport / sodium ion transportComponentsintegral component of plasma membrane / plasma membrane
- General Function
- Sodium-dependent amino acid transporter. Mediates electrogenic symport of neutral amino acids and sodium ions. Has a broad specificity, with a preference for Ala, followed by His, Cys, Asn, Ser, Gly, Val, Thr, Gln and Met. May mediate sodium-independent transport of cationic amino acids, such as Arg and Lys. Amino acid uptake is pH-dependent, with low transport activities at pH 6.5, intermediate at pH 7.0 and highest between pH 7.5 and 8.5.
- Specific Function
- Amino acid transmembrane transporter activity
- Pfam Domain Function
- Aa_trans (PF01490)
- Transmembrane Regions
- 105-125 152-172 196-216 221-241 333-353 370-390 412-432 454-474 477-497 515-535
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0052484|Sodium-coupled neutral amino acid transporter 4 (SLC38A4) ATGGATCCCATGGAACTGAGAAATGTCAACATCGAACCAGATGATGAGAGCAGCAGTGGA GAAAGTGCTCCAGATAGCTACATCGGGATAGGAAATTCAGAAAAGGCAGCAATGAGCAGT CAATTTGCTAATGAAGACACTGAAAGTCAGAAATTCCTGACAAATGGATTTTTGGGGAAA AAGAAGCTGGCAGATTATGCTGATGAACACCATCCCGGAACCACTTCCTTTGGAATGTCT TCATTTAACCTGAGTAATGCCATCATGGGCAGTGGGATCCTGGGCTTGTCCTATGCCATG GCCAACACAGGGATCATACTTTTTATAATCATGCTGCTTGCTGTGGCAATATTATCACTG TATTCAGTTCACCTTTTATTAAAAACAGCCAAGGAAGGAGGGTCTTTGATTTATGAAAAA TTAGGAGAAAAGGCATTTGGATGGCCGGGAAAAATTGGAGCTTTTGTTTCCATTACAATG CAGAACATTGGAGCAATGTCAAGCTACCTCTTTATCATTAAATATGAACTACCTGAAGTA ATCAGAGCATTCATGGGACTTGAAGAAAATACTGGAGAATGGTACCTCAATGGCAACTAC CTCATCATATTTGTGTCTGTTGGAATTATTCTTCCACTTTCGCTCCTTAAAAATTTAGGT TATCTTGGCTATACCAGTGGATTTTCTCTTACCTGCATGGTGTTTTTTGTTAGTGTGGTG ATTTACAAGAAATTCCAAATACCCTGCCCTCTACCTGTTTTGGATCACAGTGTTGGAAAT CTGTCATTCAACAACACGCTTCCAATGCATGTGGTAATGTTACCCAACAACTCTGAGAGT TCTGATGTGAACTTCATGATGGATTACACCCACCGCAATCCTGCAGGGCTGGATGAGAAC CAGGCCAAGGGCTCTCTTCATGACAGTGGAGTAGAATATGAAGCTCATAGTGATGACAAG TGTGAACCCAAATACTTTGTATTCAACTCCCGGACGGCCTATGCAATTCCTATCCTAGTA TTTGCTTTTGTATGCCACCCTGAGGTCCTTCCCATCTACAGTGAACTTAAAGATCGGTCC CGGAGAAAAATGCAAACGGTGTCAAATATTTCCATCACGGGGATGCTTGTCATGTACCTG CTTGCCGCCCTCTTTGGTTACCTAACCTTCTATGGAGAAGTTGAAGATGAATTACTTCAT GCCTACAGCAAAGTGTATACATTAGACATCCCTCTTCTCATGGTTCGCCTGGCAGTCCTT GTGGCAGTAACACTAACTGTGCCCATTGTCCTCTTCCCAATTCGTACATCAGTGATCACA CTGTTATTTCCCAAACGACCCTTCAGCTGGATACGACATTTCCTGATTGCAGCTGTGCTT ATTGCACTTAATAATGTTCTGGTCATCCTTGTGCCAACTATAAAATACATCTTCGGATTC ATAGGGGCTTCTTCTGCCACTATGCTGATTTTTATTCTTCCAGCAGTTTTTTATCTTAAA CTTGTCAAGAAAGAAACTTTTAGGTCACCCCAAAAGGTCGGGGCTTTAATTTTCCTTGTG GTTGGAATATTCTTCATGATTGGAAGCATGGCACTCATTATAATTGACTGGATTTATGAT CCTCCAAATTCCAAGCATCACTAA
- Chromosome Location
- 12
- Locus
- 12q13.11
- External Identifiers
Resource Link UniProtKB ID Q969I6 UniProtKB Entry Name S38A4_HUMAN HGNC ID HGNC:14679 - General References
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- Gu S, Adan-Rice D, Leach RJ, Jiang JX: A novel human amino acid transporter, hNAT3: cDNA cloning, chromosomal mapping, genomic structure, expression, and functional characterization. Genomics. 2001 Jun 15;74(3):262-72. doi: 10.1006/geno.2001.6567. [Article]
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- Shi Q, Padmanabhan R, Villegas CJ, Gu S, Jiang JX: Membrane topological structure of neutral system N/A amino acid transporter 4 (SNAT4) protein. J Biol Chem. 2011 Nov 4;286(44):38086-94. doi: 10.1074/jbc.M111.220277. Epub 2011 Sep 14. [Article]