Mitochondrial potassium channel

Details

Name
Mitochondrial potassium channel
Synonyms
  • Coiled-coil domain-containing protein 51
  • MITOK
Gene Name
CCDC51
Organism
Humans
Amino acid sequence
>lcl|BSEQ0052469|Mitochondrial potassium channel
MMGRSPGFAMQHIVGVPHVLVRRGLLGRDLFMTRTLCSPGPSQPGEKRPEEVALGLHHRL
PALGRALGHSIQQRATSTAKTWWDRYEEFVGLNEVREAQGKVTEAEKVFMVARGLVREAR
EDLEVHQAKLKEVRDRLDRVSREDSQYLELATLEHRMLQEEKRLRTAYLRAEDSEREKFS
LFSAAVRESHEKERTRAERTKNWSLIGSVLGALIGVAGSTYVNRVRLQELKALLLEAQKG
PVSLQEAIREQASSYSRQQRDLHNLMVDLRGLVHAAGPGQDSGSQAGSPPTRDRDVDVLS
AALKEQLSHSRQVHSCLEGLREQLDGLEKTCSQMAGVVQLVKSAAHPGLVEPADGAMPSF
LLEQGSMILALSDTEQRLEAQVNRNTIYSTLVTCVTFVATLPVLYMLFKAS
Number of residues
411
Molecular Weight
45810.91
Theoretical pI
Not Available
GO Classification
Functions
mitochondrial ATP-gated potassium channel activity
Processes
potassium ion transmembrane transport
Components
integral component of mitochondrial inner membrane / mitochondrial ATP-gated potassium channel complex
General Function
Mitochondrial potassium channel located in the mitochondrial inner membrane (PubMed:31435016). Together with ABCB8/MITOSUR, forms a protein complex localized in the mitochondria that mediates ATP-dependent potassium currents across the inner membrane (that is, mitoK(ATP) channel) (PubMed:31435016). May contribute to the homeostatic control of cellular metabolism under stress conditions by regulating the mitochondrial matrix volume (PubMed:31435016).
Specific Function
Mitochondrial atp-gated potassium channel activity
Pfam Domain Function
Not Available
Transmembrane Regions
202-222 387-407
Cellular Location
Mitochondrion inner membrane
Gene sequence
>lcl|BSEQ0052470|Mitochondrial potassium channel (CCDC51)
ATGATGGGGCGCAGCCCTGGGTTTGCCATGCAGCACATCGTGGGTGTGCCCCACGTACTG
GTTCGGAGGGGCCTCCTTGGAAGGGACCTCTTCATGACCAGGACTCTCTGCAGCCCAGGC
CCAAGCCAGCCCGGAGAGAAAAGACCTGAGGAGGTGGCCCTGGGGCTGCACCACCGCCTC
CCAGCACTGGGAAGAGCCCTGGGGCACAGCATTCAGCAACGAGCGACCTCCACAGCCAAG
ACTTGGTGGGACAGATATGAAGAGTTTGTTGGACTCAACGAGGTTCGAGAGGCCCAGGGA
AAGGTGACAGAGGCTGAGAAAGTGTTCATGGTGGCTCGAGGGCTTGTCCGAGAGGCTCGG
GAGGACTTGGAAGTTCACCAGGCCAAGCTGAAGGAGGTGAGGGACCGCTTGGACCGTGTC
TCCAGGGAGGACAGTCAGTACTTGGAACTGGCTACTCTCGAGCACAGGATGCTGCAGGAG
GAGAAGAGGCTTCGCACAGCCTATCTGCGTGCAGAAGACTCTGAGCGAGAGAAGTTCTCC
CTCTTCTCTGCAGCTGTGCGGGAAAGTCATGAGAAGGAGCGCACAAGGGCTGAGAGGACC
AAGAACTGGTCCCTCATTGGCTCAGTCCTGGGGGCCCTGATTGGTGTGGCTGGCTCCACC
TATGTGAACCGTGTGCGACTACAGGAGCTGAAGGCTTTACTCCTGGAGGCGCAGAAGGGG
CCTGTGAGTCTCCAAGAGGCCATTCGAGAACAGGCGTCTAGCTACTCCCGCCAGCAGAGG
GACCTCCACAATCTCATGGTGGACCTGAGGGGCCTGGTACATGCTGCTGGGCCAGGGCAG
GACTCTGGGTCACAGGCAGGTAGTCCCCCGACCAGAGACAGAGATGTAGATGTCCTTTCA
GCTGCCTTGAAAGAGCAGCTTAGTCATTCCAGGCAAGTCCATTCATGTCTAGAAGGCTTA
CGAGAGCAGCTTGATGGCCTAGAAAAGACTTGTAGCCAAATGGCTGGGGTGGTTCAGCTT
GTAAAGTCTGCAGCACACCCAGGCCTGGTGGAACCAGCAGACGGGGCTATGCCCAGCTTC
TTGCTGGAGCAGGGGAGCATGATCTTGGCACTGTCAGACACGGAGCAGAGACTAGAAGCC
CAAGTCAACAGGAACACCATCTATAGCACCCTGGTCACCTGTGTGACATTTGTGGCCACA
CTGCCTGTGCTCTACATGCTATTCAAAGCCAGCTAA
Chromosome Location
3
Locus
3p21.31
External Identifiers
ResourceLink
UniProtKB IDQ96ER9
UniProtKB Entry NameMITOK_HUMAN
HGNC IDHGNC:25714
General References
  1. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
  2. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  3. Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Burckstummer T, Bennett KL, Superti-Furga G, Colinge J: Initial characterization of the human central proteome. BMC Syst Biol. 2011 Jan 26;5:17. doi: 10.1186/1752-0509-5-17. [Article]
  4. Zhou H, Di Palma S, Preisinger C, Peng M, Polat AN, Heck AJ, Mohammed S: Toward a comprehensive characterization of a human cancer cell phosphoproteome. J Proteome Res. 2013 Jan 4;12(1):260-71. doi: 10.1021/pr300630k. Epub 2012 Dec 18. [Article]
  5. Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics. 2014 Jan 16;96:253-62. doi: 10.1016/j.jprot.2013.11.014. Epub 2013 Nov 22. [Article]
  6. Vaca Jacome AS, Rabilloud T, Schaeffer-Reiss C, Rompais M, Ayoub D, Lane L, Bairoch A, Van Dorsselaer A, Carapito C: N-terminome analysis of the human mitochondrial proteome. Proteomics. 2015 Jul;15(14):2519-24. doi: 10.1002/pmic.201400617. Epub 2015 Jun 8. [Article]
  7. Paggio A, Checchetto V, Campo A, Menabo R, Di Marco G, Di Lisa F, Szabo I, Rizzuto R, De Stefani D: Identification of an ATP-sensitive potassium channel in mitochondria. Nature. 2019 Aug;572(7771):609-613. doi: 10.1038/s41586-019-1498-3. Epub 2019 Aug 21. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB01236Sevofluraneapproved, vet_approvedyesactivatorDetails