Potassium voltage-gated channel subfamily S member 1

Details

Name

Potassium voltage-gated channel subfamily S member 1

Synonyms

• Delayed-rectifier K(+) channel alpha subunit 1
• Voltage-gated potassium channel subunit Kv9.1

Gene Name

KCNS1

Organism

Humans

Amino acid sequence

>lcl|BSEQ0052247|Potassium voltage-gated channel subfamily S member 1
MLMLLVRGTHYENLRSKVVLPTPLGGRSTETFVSEFPGPDTGIRWRRSDEALRVNVGGVR
RQLSARALARFPGTRLGRLQAAASEEQARRLCDDYDEAAREFYFDRHPGFFLSLLHFYRT
GHLHVLDELCVFAFGQEADYWGLGENALAACCRARYLERRLTQPHAWDEDSDTPSSVDPC
PDEISDVQRELARYGAARCGRLRRRLWLTMENPGYSLPSKLFSCVSISVVLASIAAMCIH
SLPEYQAREAAAAVAAVAAGRSPEGVRDDPVLRRLEYFCIAWFSFEVSSRLLLAPSTRNF
FCHPLNLIDIVSVLPFYLTLLAGVALGDQGGKEFGHLGKVVQVFRLMRIFRVLKLARHST
GLRSLGATLKHSYREVGILLLYLAVGVSVFSGVAYTAEKEEDVGFNTIPACWWWGTVSMT
TVGYGDVVPVTVAGKLAASGCILGGILVVALPITIIFNKFSHFYRRQKALEAAVRNSNHQ
EFEDLLSSIDGVSEASLETSRETSQEGQSADLESQAPSEPPHPQMY

Number of residues

526

Molecular Weight

58371.045

Theoretical pI

Not Available

GO Classification

Functions

delayed rectifier potassium channel activity / potassium channel regulator activity / voltage-gated potassium channel activity

Processes

potassium ion transmembrane transport / potassium ion transport / protein homooligomerization / regulation of delayed rectifier potassium channel activity

Components

integral component of membrane / perinuclear region of cytoplasm / plasma membrane / voltage-gated potassium channel complex

General Function

Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1 and KCNB2; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2 (PubMed:10484328).

Specific Function

Delayed rectifier potassium channel activity

Pfam Domain Function

• Ion_trans (PF00520)
• BTB_2 (PF02214)

Transmembrane Regions

218-239 271-293 305-322 338-358 374-395 436-464

Cellular Location

Cell membrane

Gene sequence

>lcl|BSEQ0052248|Potassium voltage-gated channel subfamily S member 1 (KCNS1)
ATGCTGATGCTGCTGGTCCGGGGAACACACTATGAGAACCTCCGGTCTAAAGTGGTGCTG
CCAACACCCCTAGGAGGGAGGAGCACTGAAACCTTTGTGAGCGAGTTCCCGGGCCCCGAC
ACCGGGATCCGCTGGCGGCGAAGCGACGAGGCGCTGCGCGTGAACGTGGGTGGCGTGCGG
CGGCAGCTGAGCGCGCGCGCCCTGGCGCGCTTCCCGGGCACGCGGCTGGGCCGCCTGCAG
GCCGCGGCGTCGGAGGAGCAGGCGCGGCGCCTGTGCGACGACTACGACGAGGCGGCGCGC
GAATTCTACTTCGACCGGCACCCGGGCTTCTTCCTGAGCCTGCTGCACTTCTACCGCACT
GGCCACCTGCACGTGCTCGACGAGCTGTGCGTCTTCGCCTTTGGCCAGGAGGCCGACTAC
TGGGGCCTAGGCGAGAACGCGCTTGCCGCGTGCTGCCGCGCGCGCTACCTGGAGAGGCGG
CTGACCCAGCCGCACGCCTGGGACGAGGACAGCGACACGCCGAGCAGCGTGGACCCGTGC
CCCGACGAGATCTCCGACGTGCAGCGAGAACTGGCGCGCTATGGCGCGGCGCGCTGTGGC
CGCCTGCGCCGCCGCCTCTGGCTGACCATGGAGAACCCGGGCTACTCGCTGCCGAGCAAG
CTCTTCAGCTGCGTCTCCATCAGCGTGGTGCTCGCCTCCATCGCCGCCATGTGCATCCAC
AGCCTGCCCGAGTACCAGGCCCGCGAGGCGGCGGCCGCCGTGGCTGCGGTGGCCGCGGGC
CGCAGCCCGGAAGGCGTGCGCGACGACCCGGTGCTGCGACGCCTCGAGTACTTCTGCATC
GCCTGGTTCAGCTTCGAGGTGTCGTCGCGCCTCCTGCTGGCGCCCAGTACGCGCAACTTC
TTCTGCCACCCGCTCAACCTCATCGACATTGTGTCTGTGCTGCCCTTCTATCTCACGCTG
CTGGCTGGTGTGGCACTGGGCGACCAGGGCGGCAAGGAGTTCGGCCACCTGGGCAAGGTG
GTGCAGGTGTTCCGCCTCATGCGCATCTTCCGCGTACTCAAGTTGGCGCGCCATTCCACC
GGGCTGCGCTCGCTGGGAGCCACGCTCAAGCACAGCTACCGTGAGGTGGGCATCTTGCTG
CTGTACCTGGCTGTGGGTGTGTCAGTGTTCTCTGGTGTGGCCTACACAGCTGAAAAGGAG
GAGGACGTGGGCTTTAACACCATCCCAGCCTGCTGGTGGTGGGGCACAGTGAGCATGACC
ACCGTGGGCTATGGGGATGTGGTGCCAGTGACGGTGGCTGGCAAGCTGGCAGCCTCAGGC
TGCATCCTAGGGGGCATCCTGGTGGTAGCACTCCCCATCACCATCATCTTCAACAAGTTC
TCCCACTTCTACCGGCGCCAGAAGGCTCTGGAGGCAGCCGTGCGCAACAGCAACCACCAA
GAGTTTGAGGACTTGCTGAGCAGCATTGATGGGGTGTCGGAGGCATCTCTGGAGACATCC
CGAGAAACCTCTCAGGAGGGACAGTCTGCAGATCTAGAGAGCCAGGCCCCCAGTGAGCCT
CCACACCCTCAGATGTATTAA

Chromosome Location

20

Locus

20q13.12

External Identifiers

Resource	Link
UniProtKB ID	Q96KK3
UniProtKB Entry Name	KCNS1_HUMAN
HGNC ID	HGNC:6300

General References

1. Shepard AR, Rae JL: Electrically silent potassium channel subunits from human lens epithelium. Am J Physiol. 1999 Sep;277(3 Pt 1):C412-24. [Article]
2. Deloukas P, Matthews LH, Ashurst J, Burton J, Gilbert JG, Jones M, Stavrides G, Almeida JP, Babbage AK, Bagguley CL, Bailey J, Barlow KF, Bates KN, Beard LM, Beare DM, Beasley OP, Bird CP, Blakey SE, Bridgeman AM, Brown AJ, Buck D, Burrill W, Butler AP, Carder C, Carter NP, Chapman JC, Clamp M, Clark G, Clark LN, Clark SY, Clee CM, Clegg S, Cobley VE, Collier RE, Connor R, Corby NR, Coulson A, Coville GJ, Deadman R, Dhami P, Dunn M, Ellington AG, Frankland JA, Fraser A, French L, Garner P, Grafham DV, Griffiths C, Griffiths MN, Gwilliam R, Hall RE, Hammond S, Harley JL, Heath PD, Ho S, Holden JL, Howden PJ, Huckle E, Hunt AR, Hunt SE, Jekosch K, Johnson CM, Johnson D, Kay MP, Kimberley AM, King A, Knights A, Laird GK, Lawlor S, Lehvaslaiho MH, Leversha M, Lloyd C, Lloyd DM, Lovell JD, Marsh VL, Martin SL, McConnachie LJ, McLay K, McMurray AA, Milne S, Mistry D, Moore MJ, Mullikin JC, Nickerson T, Oliver K, Parker A, Patel R, Pearce TA, Peck AI, Phillimore BJ, Prathalingam SR, Plumb RW, Ramsay H, Rice CM, Ross MT, Scott CE, Sehra HK, Shownkeen R, Sims S, Skuce CD, Smith ML, Soderlund C, Steward CA, Sulston JE, Swann M, Sycamore N, Taylor R, Tee L, Thomas DW, Thorpe A, Tracey A, Tromans AC, Vaudin M, Wall M, Wallis JM, Whitehead SL, Whittaker P, Willey DL, Williams L, Williams SA, Wilming L, Wray PW, Hubbard T, Durbin RM, Bentley DR, Beck S, Rogers J: The DNA sequence and comparative analysis of human chromosome 20. Nature. 2001 Dec 20-27;414(6866):865-71. [Article]
3. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]

Drug Relations

Drug Relations

DrugBank ID	Name	Drug group	Pharmacological action?	Actions	Details
DB00228	Enflurane	approved, investigational, vet_approved	unknown	inhibitoractivator	Details
DB01069	Promethazine	approved, investigational	unknown	inducer	Details
DB01110	Miconazole	approved, investigational, vet_approved	unknown	inhibitor	Details