Sodium-coupled neutral amino acid transporter 2

Details

Name
Sodium-coupled neutral amino acid transporter 2
Synonyms
  • Amino acid transporter A2
  • ATA2
  • KIAA1382
  • Protein 40-9-1
  • SAT2
  • SNAT2
  • Solute carrier family 38 member 2
  • System A amino acid transporter 2
  • System A transporter 1
  • System N amino acid transporter 2
Gene Name
SLC38A2
Organism
Humans
Amino acid sequence
>lcl|BSEQ0052309|Sodium-coupled neutral amino acid transporter 2
MKKAEMGRFSISPDEDSSSYSSNSDFNYSYPTKQAALKSHYADVDPENQNFLLESNLGKK
KYETEFHPGTTSFGMSVFNLSNAIVGSGILGLSYAMANTGIALFIILLTFVSIFSLYSVH
LLLKTANEGGSLLYEQLGYKAFGLVGKLAASGSITMQNIGAMSSYLFIVKYELPLVIQAL
TNIEDKTGLWYLNGNYLVLLVSLVVILPLSLFRNLGYLGYTSGLSLLCMVFFLIVVICKK
FQVPCPVEAALIINETINTTLTQPTALVPALSHNVTENDSCRPHYFIFNSQTVYAVPILI
FSFVCHPAVLPIYEELKDRSRRRMMNVSKISFFAMFLMYLLAALFGYLTFYEHVESELLH
TYSSILGTDILLLIVRLAVLMAVTLTVPVVIFPIRSSVTHLLCASKDFSWWRHSLITVSI
LAFTNLLVIFVPTIRDIFGFIGASAASMLIFILPSAFYIKLVKKEPMKSVQKIGALFFLL
SGVLVMTGSMALIVLDWVHNAPGGGH
Number of residues
506
Molecular Weight
56025.375
Theoretical pI
Not Available
GO Classification
Functions
amino acid transmembrane transporter activity / L-glutamine transmembrane transporter activity / symporter activity
Processes
alanine transport / amino acid transmembrane transport / amino acid transport / cellular response to amino acid starvation / cellular response to mechanical stimulus / cerebral cortex development / female pregnancy / glutamate secretion / glycine betaine transport / sodium ion transport
Components
axon / brush border / dendrite / integral component of plasma membrane / neuronal cell body / plasma membrane / sarcolemma
General Function
Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood-brain barrier and in the supply of maternal nutrients to the fetus through the placenta.
Specific Function
Amino acid transmembrane transporter activity
Pfam Domain Function
Transmembrane Regions
77-97 103-123 159-179 189-209 218-238 293-313 330-350 372-392 414-434 437-457 475-495
Cellular Location
Cell membrane
Gene sequence
>lcl|BSEQ0052310|Sodium-coupled neutral amino acid transporter 2 (SLC38A2)
ATGAAGAAGGCCGAAATGGGACGATTCAGTATTTCCCCGGATGAAGACAGCAGCAGCTAC
AGTTCCAACAGCGACTTCAACTACTCCTACCCCACCAAGCAAGCTGCTCTGAAAAGCCAT
TATGCAGATGTAGATCCTGAAAACCAGAACTTTTTACTTGAATCGAATTTGGGGAAGAAG
AAGTATGAAACAGAATTTCATCCAGGTACTACTTCCTTTGGAATGTCAGTATTTAATCTG
AGCAATGCGATTGTGGGCAGTGGAATCCTTGGGCTTTCTTATGCCATGGCTAATACTGGA
ATTGCTCTTTTTATAATTCTCTTGACATTTGTGTCAATATTTTCCCTGTATTCTGTTCAT
CTCCTTTTGAAGACTGCCAATGAAGGAGGGTCTTTATTATATGAACAATTGGGATATAAG
GCATTTGGATTAGTTGGAAAGCTTGCAGCATCTGGATCAATTACAATGCAGAACATTGGA
GCTATGTCAAGCTACCTCTTCATAGTGAAATATGAGTTGCCTTTGGTGATCCAGGCATTA
ACGAACATTGAAGATAAAACTGGATTGTGGTATCTGAACGGGAACTATTTGGTTCTGTTG
GTGTCATTGGTGGTCATTCTTCCTTTGTCGCTGTTTAGAAATTTAGGATATTTGGGATAT
ACCAGTGGCCTTTCCTTGTTGTGTATGGTGTTCTTTCTGATTGTGGTCATTTGCAAGAAA
TTTCAGGTTCCGTGTCCTGTGGAAGCTGCTTTGATAATTAACGAAACAATAAACACCACC
TTAACACAGCCAACAGCTCTTGTACCTGCTTTGTCACATAACGTGACTGAAAATGACTCT
TGCAGACCTCACTATTTTATTTTCAACTCACAGACTGTCTATGCTGTGCCAATTCTGATC
TTTTCATTTGTCTGTCATCCTGCTGTTCTTCCCATCTATGAAGAACTGAAAGACCGCAGC
CGTAGAAGAATGATGAATGTGTCCAAGATTTCATTTTTTGCTATGTTTCTCATGTATCTG
CTTGCCGCCCTCTTTGGATACCTAACATTTTACGAACATGTTGAGTCAGAATTGCTTCAT
ACCTACTCTTCTATCTTGGGAACTGATATTCTTCTTCTCATTGTCCGTCTGGCTGTGTTA
ATGGCTGTGACCCTGACAGTACCAGTAGTTATTTTCCCAATCCGGAGTTCTGTAACTCAC
TTGTTGTGTGCATCAAAAGATTTCAGTTGGTGGCGTCATAGTCTCATTACAGTGTCTATC
TTGGCATTTACCAATTTACTTGTCATCTTTGTCCCAACTATTAGGGATATCTTTGGTTTT
ATTGGTGCATCTGCAGCTTCTATGTTGATTTTTATTCTTCCTTCTGCCTTCTATATCAAG
TTGGTGAAGAAAGAACCTATGAAATCTGTACAAAAGATTGGGGCTTTGTTCTTCCTGTTA
AGTGGTGTACTGGTGATGACCGGAAGCATGGCCTTGATTGTTTTGGATTGGGTACACAAT
GCACCTGGAGGTGGCCATTAA
Chromosome Location
12
Locus
12q13.11
External Identifiers
ResourceLink
UniProtKB IDQ96QD8
UniProtKB Entry NameS38A2_HUMAN
HGNC IDHGNC:13448
General References
  1. Hatanaka T, Huang W, Wang H, Sugawara M, Prasad PD, Leibach FH, Ganapathy V: Primary structure, functional characteristics and tissue expression pattern of human ATA2, a subtype of amino acid transport system A. Biochim Biophys Acta. 2000 Jul 31;1467(1):1-6. doi: 10.1016/s0005-2736(00)00252-2. [Article]
  2. Nagase T, Kikuno R, Ishikawa KI, Hirosawa M, Ohara O: Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 2000 Feb 28;7(1):65-73. [Article]
  3. Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. DNA Res. 2002 Jun 30;9(3):99-106. [Article]
  4. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
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  6. Palii SS, Chen H, Kilberg MS: Transcriptional control of the human sodium-coupled neutral amino acid transporter system A gene by amino acid availability is mediated by an intronic element. J Biol Chem. 2004 Jan 30;279(5):3463-71. doi: 10.1074/jbc.M310483200. Epub 2003 Nov 17. [Article]
  7. Bevilacqua E, Bussolati O, Dall'Asta V, Gaccioli F, Sala R, Gazzola GC, Franchi-Gazzola R: SNAT2 silencing prevents the osmotic induction of transport system A and hinders cell recovery from hypertonic stress. FEBS Lett. 2005 Jun 20;579(16):3376-80. doi: 10.1016/j.febslet.2005.05.002. [Article]
  8. Gonzalez-Gonzalez IM, Cubelos B, Gimenez C, Zafra F: Immunohistochemical localization of the amino acid transporter SNAT2 in the rat brain. Neuroscience. 2005;130(1):61-73. doi: 10.1016/j.neuroscience.2004.09.023. [Article]
  9. Gaccioli F, Huang CC, Wang C, Bevilacqua E, Franchi-Gazzola R, Gazzola GC, Bussolati O, Snider MD, Hatzoglou M: Amino acid starvation induces the SNAT2 neutral amino acid transporter by a mechanism that involves eukaryotic initiation factor 2alpha phosphorylation and cap-independent translation. J Biol Chem. 2006 Jun 30;281(26):17929-40. doi: 10.1074/jbc.M600341200. Epub 2006 Apr 18. [Article]
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00130L-Glutamineapproved, investigational, nutraceuticalunknownsubstrateDetails
DB00174Asparagineapproved, investigational, nutraceuticalyesinhibitorDetails