Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3
Details
- Name
- Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3
- Synonyms
- NaMN adenylyltransferase 3
- Nicotinamide-nucleotide adenylyltransferase 3
- Nicotinate-nucleotide adenylyltransferase 3
- NMN adenylyltransferase 3
- NMN/NaMN adenylyltransferase 3
- PNAT-3
- Pyridine nucleotide adenylyltransferase 3
- Gene Name
- NMNAT3
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0003630|Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 MKSRIPVVLLACGSFNPITNMHLRMFEVARDHLHQTGMYQVIQGIISPVNDTYGKKDLAA SHHRVAMARLALQTSDWIRVDPWESEQAQWMETVKVLRHHHSKLLRSPPQMEGPDHGKAL FSTPAAVPELKLLCGADVLKTFQTPNLWKDAHIQEIVEKFGLVCVGRVGHDPKGYIAESP ILRMHQHNIHLAKEPVQNEISATYIRRALGQGQSVKYLIPDAVITYIKDHGLYTKGSTWK GKSTQSTEGKTS
- Number of residues
- 252
- Molecular Weight
- 28321.525
- Theoretical pI
- 9.69
- GO Classification
- FunctionsATP binding / nicotinamide-nucleotide adenylyltransferase activity / nicotinate-nucleotide adenylyltransferase activityProcesses'de novo' NAD biosynthetic process from aspartate / NAD biosynthetic process / NAD metabolic process / response to wounding / small molecule metabolic process / vitamin metabolic process / water-soluble vitamin metabolic processComponentscytosol / mitochondrion
- General Function
- Nicotinate-nucleotide adenylyltransferase activity
- Specific Function
- Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD(+), NADH, NaAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+). Protects against axonal degeneration following injury.
- Pfam Domain Function
- CTP_transf_like (PF01467)
- Transmembrane Regions
- Not Available
- Cellular Location
- Mitochondrion
- Gene sequence
>lcl|BSEQ0016577|Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 (NMNAT3) ATGAAGAGCCGAATACCTGTGGTGCTCCTGGCCTGTGGCTCCTTTAACCCCATCACCAAC ATGCACCTGCGCATGTTTGAGGTGGCCAGAGATCACCTACACCAAACAGCTGTGCCTGAG CTGAAGCTTCTCTGTGGGGCAGACGTCTTGAAGACCTTCCAGACCCCCAACCTCTGGAAG GATGCGCACATCCAGGAAATAGTGGAGAAGTTTGGCTTGGTGTGCGTGGGCCGAGTAGGT CACGACCCAAAAGGTTACATCGCAGAATCTCCCATCCTACGGATGCACCAGCACAACATT CACCTGGCCAAGGAGCCTGTGCAGAATGAGATCAGTGCCACATACATCAGGCGAGCCTTG GGCCAAGGGCAGAGCGTAAAGTACCTGATTCCCGATGCTGTCATCACGTACATCAAGGAC CATGGCCTCTACACCAAGGGCAGTACCTGGAAAGGCAAAAGCACCCAGAGCACTGAGGGC AAGACAAGCTAG
- Chromosome Location
- 3
- Locus
- 3q23
- External Identifiers
Resource Link UniProtKB ID Q96T66 UniProtKB Entry Name NMNA3_HUMAN GenBank Protein ID 14029540 GenBank Gene ID AF345564 GenAtlas ID NMNAT3 HGNC ID HGNC:20989 - General References
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