V-type proton ATPase 21 kDa proteolipid subunit

Details

Name
V-type proton ATPase 21 kDa proteolipid subunit
Synonyms
  • ATP6F
  • hATPL
  • V-ATPase 21 kDa proteolipid subunit
  • Vacuolar proton pump 21 kDa proteolipid subunit
Gene Name
ATP6V0B
Organism
Humans
Amino acid sequence
>lcl|BSEQ0052435|V-type proton ATPase 21 kDa proteolipid subunit
MTGLALLYSGVFVAFWACALAVGVCYTIFDLGFRFDVAWFLTETSPFMWSNLGIGLAISL
SVVGAAWGIYITGSSIIGGGVKAPRIKTKNLVSIIFCEAVAIYGIIMAIVISNMAEPFSA
TDPKAIGHRNYHAGYSMFGAGLTVGLSNLFCGVCVGIVGSGAALADAQNPSLFVKILIVE
IFGSAIGLFGVIVAILQTSRVKMGD
Number of residues
205
Molecular Weight
21406.09
Theoretical pI
Not Available
GO Classification
Functions
proton-transporting ATPase activity, rotational mechanism / transporter activity
Processes
insulin receptor signaling pathway / ion transmembrane transport / phagosome acidification / proton transmembrane transport / regulation of macroautophagy / transferrin transport
Components
cell / endosome membrane / integral component of membrane / phagocytic vesicle membrane / proton-transporting V-type ATPase, V0 domain / vacuolar membrane
General Function
Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
Specific Function
Proton-transporting atpase activity, rotational mechanism
Pfam Domain Function
Transmembrane Regions
4-24 52-72 91-111 138-158 176-196
Cellular Location
Vacuole membrane
Gene sequence
>lcl|BSEQ0052436|V-type proton ATPase 21 kDa proteolipid subunit (ATP6V0B)
ATGACGGGGCTAGCACTGCTCTACTCCGGGGTCTTCGTGGCCTTCTGGGCCTGCGCGCTG
GCCGTGGGAGTCTGCTACACCATTTTTGATTTGGGCTTCCGCTTTGATGTGGCATGGTTC
CTGACGGAGACTTCGCCCTTCATGTGGTCCAACCTGGGCATTGGCCTAGCTATCTCCCTG
TCTGTGGTTGGGGCAGCCTGGGGCATCTATATTACCGGCTCCTCCATCATTGGTGGAGGA
GTGAAGGCCCCCAGGATCAAGACCAAGAACCTGGTCAGCATCATCTTCTGTGAGGCTGTG
GCCATCTACGGCATCATCATGGCAATTGTCATTAGCAACATGGCTGAGCCTTTCAGTGCC
ACAGACCCCAAGGCCATCGGCCATCGGAACTACCATGCAGGCTACTCCATGTTTGGGGCT
GGCCTCACCGTAGGCCTGTCTAACCTCTTCTGTGGAGTCTGCGTGGGCATCGTGGGCAGT
GGGGCTGCCCTGGCCGATGCTCAGAACCCCAGCCTCTTTGTAAAGATTCTCATCGTGGAG
ATCTTTGGCAGCGCCATTGGCCTCTTTGGGGTCATCGTCGCAATTCTTCAGACCTCCAGA
GTGAAGATGGGTGACTAG
Chromosome Location
1
Locus
1p34.1
External Identifiers
ResourceLink
UniProtKB IDQ99437
UniProtKB Entry NameVATO_HUMAN
HGNC IDHGNC:861
General References
  1. Nishigori H, Yamada S, Tomura H, Fernald AA, Le Beau MM, Takeuchi T, Takeda J: Identification and characterization of the gene encoding a second proteolipid subunit of human vacuolar H(+)-ATPase (ATP6F). Genomics. 1998 Jun 1;50(2):222-8. doi: 10.1006/geno.1998.5310. [Article]
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  4. Sjoblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, Mandelker D, Leary RJ, Ptak J, Silliman N, Szabo S, Buckhaults P, Farrell C, Meeh P, Markowitz SD, Willis J, Dawson D, Willson JK, Gazdar AF, Hartigan J, Wu L, Liu C, Parmigiani G, Park BH, Bachman KE, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE: The consensus coding sequences of human breast and colorectal cancers. Science. 2006 Oct 13;314(5797):268-74. Epub 2006 Sep 7. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB01133Tiludronic acidapproved, investigational, vet_approvedunknowninhibitorDetails