Keratin, type I cytoskeletal 12
Details
- Name
- Keratin, type I cytoskeletal 12
- Synonyms
- CK-12
- Cytokeratin-12
- K12
- Keratin-12
- Gene Name
- KRT12
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0017500|Keratin, type I cytoskeletal 12 MDLSNNTMSLSVRTPGLSRRLSSQSVIGRPRGMSASSVGSGYGGSAFGFGASCGGGFSAA SMFGSSSGFGGGSGSSMAGGLGAGYGRALGGGSFGGLGMGFGGSPGGGSLGILSGNDGGL LSGSEKETMQNLNDRLASYLDKVRALEEANTELENKIREWYETRGTGTADASQSDYSKYY PLIEDLRNKIISASIGNAQLLLQIDNARLAAEDFRMKYENELALRQGVEADINGLRRVLD ELTLTRTDLEMQIESLNEELAYMKKNHEDELQSFRVGGPGEVSVEMDAAPGVDLTRLLND MRAQYETIAEQNRKDAEAWFIEKSGELRKEISTNTEQLQSSKSEVTDLRRAFQNLEIELQ SQLAMKKSLEDSLAEAEGDYCAQLSQVQQLISNLEAQLLQVRADAERQNVDHQRLLNVKA RLELEIETYRRLLDGEAQGDGLEESLFVTDSKSQAQSTDSSKDPTKTRKIKTVVQEMVNG EVVSSQVQEIEELM
- Number of residues
- 494
- Molecular Weight
- 53510.935
- Theoretical pI
- Not Available
- GO Classification
- Functionsstructural molecule activityProcessescornea development in camera-type eye / epithelium development / visual perceptionComponentsextracellular exosome / intermediate filament
- General Function
- Structural molecule activity
- Specific Function
- May play a unique role in maintaining the normal corneal epithelial function. Together with KRT3, essential for the maintenance of corneal epithelium integrity (By similarity).
- Pfam Domain Function
- Filament (PF00038)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0017501|Keratin, type I cytoskeletal 12 (KRT12) ATGGATCTCTCCAACAACACCATGTCACTCTCAGTGCGCACCCCCGGACTGTCCCGGCGG CTCTCCTCGCAGAGTGTGATAGGCAGACCCAGGGGCATGTCTGCTTCCAGTGTTGGAAGT GGTTATGGGGGAAGTGCCTTTGGCTTTGGAGCCAGCTGTGGGGGAGGCTTTTCTGCTGCT TCCATGTTTGGTTCTAGTTCCGGCTTTGGGGGTGGCTCCGGAAGTTCCATGGCAGGAGGA CTGGGTGCTGGTTATGGGAGAGCCCTGGGTGGAGGTAGCTTTGGAGGGCTGGGGATGGGA TTTGGGGGCAGCCCAGGAGGTGGCTCTCTAGGTATTCTCTCGGGCAATGATGGAGGCCTT CTTTCTGGATCAGAAAAAGAAACTATGCAAAATCTTAATGATAGATTAGCTTCCTACCTG GATAAGGTGCGAGCTCTAGAAGAGGCTAATACTGAGCTAGAAAATAAAATTCGAGAATGG TATGAAACACGAGGAACTGGGACTGCAGATGCTTCACAGAGCGATTACAGCAAATATTAT CCACTGATTGAAGACCTCAGGAATAAGATCATTTCAGCCAGCATTGGAAATGCCCAGCTC CTCTTGCAGATTGACAATGCGAGACTAGCTGCTGAGGACTTCAGGATGAAGTATGAGAAT GAACTGGCCCTGCGCCAGGGCGTAGAGGCCGACATCAATGGCCTGCGCCGGGTGCTGGAC GAGCTGACCCTGACCAGGACCGACCTGGAGATGCAGATCGAGAGCCTGAACGAGGAGCTG GCCTACATGAAGAAGAACCACGAGGATGAGCTCCAAAGCTTCCGGGTGGGCGGCCCAGGC GAGGTCAGCGTAGAAATGGACGCTGCCCCCGGAGTGGACCTCACCAGGCTCCTCAATGAT ATGCGGGCGCAGTATGAAACCATCGCTGAGCAGAATCGGAAGGACGCTGAAGCCTGGTTC ATTGAAAAGAGCGGGGAGCTCCGTAAGGAGATTAGCACCAACACCGAGCAGCTTCAGTCC AGCAAGAGCGAGGTCACCGACCTGCGTCGCGCCTTTCAGAACCTGGAGATCGAGCTACAG TCCCAGCTCGCCATGAAGAAATCCCTGGAGGACTCCTTGGCCGAAGCCGAGGGCGATTAC TGCGCGCAGCTGTCCCAGGTGCAGCAGCTCATCAGCAACCTGGAGGCACAGCTGCTCCAG GTGCGCGCGGACGCAGAGCGCCAGAACGTGGACCACCAGCGGCTGCTGAATGTCAAGGCC CGCCTGGAGCTGGAGATTGAGACCTACCGCCGCCTGCTGGACGGGGAGGCCCAAGGTGAT GGTTTGGAGGAAAGTTTATTTGTGACAGACTCCAAATCACAAGCACAGTCAACTGATTCC TCTAAAGACCCAACCAAAACCCGAAAAATCAAGACAGTTGTGCAGGAGATGGTGAATGGT GAGGTGGTCTCATCTCAAGTTCAGGAAATTGAAGAACTAATGTAA
- Chromosome Location
- 17
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q99456 UniProtKB Entry Name K1C12_HUMAN HGNC ID HGNC:6414 - General References
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