Sphingosine 1-phosphate receptor 3

Details

Name

Sphingosine 1-phosphate receptor 3

Synonyms

• EDG3
• Endothelial differentiation G-protein coupled receptor 3
• S1P receptor 3
• S1P receptor Edg-3
• Sphingosine 1-phosphate receptor Edg-3

Gene Name

S1PR3

Organism

Humans

Amino acid sequence

>lcl|BSEQ0052327|Sphingosine 1-phosphate receptor 3
MATALPPRLQPVRGNETLREHYQYVGKLAGRLKEASEGSTLTTVLFLVICSFIVLENLMV
LIAIWKNNKFHNRMYFFIGNLALCDLLAGIAYKVNILMSGKKTFSLSPTVWFLREGSMFV
ALGASTCSLLAIAIERHLTMIKMRPYDANKRHRVFLLIGMCWLIAFTLGALPILGWNCLH
NLPDCSTILPLYSKKYIAFCISIFTAILVTIVILYARIYFLVKSSSRKVANHNNSERSMA
LLRTVVIVVSVFIACWSPLFILFLIDVACRVQACPILFKAQWFIVLAVLNSAMNPVIYTL
ASKEMRRAFFRLVCNCLVRGRGARASPIQPALDPSRSKSSSSNNSSHSPKVKEDLPHTAP
SSCIMDKNAALQNGIFCN

Number of residues

378

Molecular Weight

42249.805

Theoretical pI

Not Available

GO Classification

Functions

G protein-coupled receptor activity / integrin binding / lipid binding / sphingosine-1-phosphate receptor activity

Processes

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway / anatomical structure morphogenesis / cytokine production / G protein-coupled receptor signaling pathway / inflammatory response / negative regulation of establishment of endothelial barrier / Notch signaling pathway / positive regulation of cell population proliferation / positive regulation of cytosolic calcium ion concentration / regulation of interleukin-1 beta production

Components

cell / integral component of plasma membrane / plasma membrane

General Function

Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis.

Specific Function

G protein-coupled receptor activity

Pfam Domain Function

• 7tm_1 (PF00001)

Transmembrane Regions

41-65 73-101 116-134 154-179 196-216 244-265 282-302

Cellular Location

Cell membrane

Gene sequence

>lcl|BSEQ0052328|Sphingosine 1-phosphate receptor 3 (S1PR3)
ATGGCAACTGCCCTCCCGCCGCGTCTCCAGCCGGTGCGGGGGAACGAGACCCTGCGGGAG
CATTACCAGTACGTGGGGAAGTTGGCGGGCAGGCTGAAGGAGGCCTCCGAGGGCAGCACG
CTCACCACCGTGCTCTTCTTGGTCATCTGCAGCTTCATCGTCTTGGAGAACCTGATGGTT
TTGATTGCCATCTGGAAAAACAATAAATTTCACAACCGCATGTACTTTTTCATTGGCAAC
CTGGCTCTCTGCGACCTGCTGGCCGGCATCGCTTACAAGGTCAACATTCTGATGTCTGGC
AAGAAGACGTTCAGCCTGTCTCCCACGGTCTGGTTCCTCAGGGAGGGCAGTATGTTCGTG
GCCCTTGGGGCGTCCACCTGCAGCTTACTGGCCATCGCCATCGAGCGGCACTTGACAATG
ATCAAAATGAGGCCTTACGACGCCAACAAGAGGCACCGCGTCTTCCTCCTGATCGGGATG
TGCTGGCTCATTGCCTTCACGCTGGGCGCCCTGCCCATTCTGGGCTGGAACTGCCTGCAC
AATCTCCCTGACTGCTCTACCATCCTGCCCCTCTACTCCAAGAAGTACATTGCCTTCTGC
ATCAGCATCTTCACGGCCATCCTGGTGACCATCGTGATCCTCTACGCACGCATCTACTTC
CTGGTGAAGTCCAGCAGCCGTAAGGTGGCCAACCACAACAACTCGGAGCGGTCCATGGCA
CTGCTGCGGACCGTGGTGATTGTGGTGAGCGTGTTCATCGCCTGCTGGTCCCCACTCTTC
ATCCTCTTCCTCATTGATGTGGCCTGCAGGGTGCAGGCGTGCCCCATCCTCTTCAAGGCT
CAGTGGTTCATCGTGTTGGCTGTGCTCAACTCCGCCATGAACCCGGTCATCTACACGCTG
GCCAGCAAGGAGATGCGGCGGGCCTTCTTCCGTCTGGTCTGCAACTGCCTGGTCAGGGGA
CGGGGGGCCCGCGCCTCACCCATCCAGCCTGCGCTCGACCCAAGCAGAAGTAAATCAAGC
AGCAGCAACAATAGCAGCCACTCTCCGAAGGTCAAGGAAGACCTGCCCCACACAGCCCCC
TCATCCTGCATCATGGACAAGAACGCAGCACTTCAGAATGGGATCTTCTGCAACTGA

Chromosome Location

9

Locus

9q22.1

External Identifiers

Resource	Link
UniProtKB ID	Q99500
UniProtKB Entry Name	S1PR3_HUMAN
HGNC ID	HGNC:3167

General References

1. Yamaguchi F, Tokuda M, Hatase O, Brenner S: Molecular cloning of the novel human G protein-coupled receptor (GPCR) gene mapped on chromosome 9. Biochem Biophys Res Commun. 1996 Oct 14;227(2):608-14. [Article]
2. An S, Bleu T, Huang W, Hallmark OG, Coughlin SR, Goetzl EJ: Identification of cDNAs encoding two G protein-coupled receptors for lysosphingolipids. FEBS Lett. 1997 Nov 17;417(3):279-82. [Article]
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Drug Relations

Drug Relations

DrugBank ID	Name	Drug group	Pharmacological action?	Actions	Details
DB08868	Fingolimod	approved, investigational	yes	modulator	Details