Protein arginine N-methyltransferase 1

Details

Name
Protein arginine N-methyltransferase 1
Synonyms
  • 2.1.1.319
  • Histone-arginine N-methyltransferase PRMT1
  • HMT2
  • HRMT1L2
  • Interferon receptor 1-bound protein 4
  • IR1B4
Gene Name
PRMT1
Organism
Humans
Amino acid sequence
>lcl|BSEQ0009518|Protein arginine N-methyltransferase 1
MENFVATLANGMSLQPPLEEVSCGQAESSEKPNAEDMTSKDYYFDSYAHFGIHEEMLKDE
VRTLTYRNSMFHNRHLFKDKVVLDVGSGTGILCMFAAKAGARKVIGIECSSISDYAVKIV
KANKLDHVVTIIKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVLYARDKWLAPDGL
IFPDRATLYVTAIEDRQYKDYKIHWWENVYGFDMSCIKDVAIKEPLVDVVDPKQLVTNAC
LIKEVDIYTVKVEDLTFTSPFCLQVKRNDYVHALVAYFNIEFTRCHKRTGFSTSPESPYT
HWKQTVFYMEDYLTVKTGEEIFGTIGMRPNAKNNRDLDFTIDLDFKGQLCELSCSTDYRM
R
Number of residues
361
Molecular Weight
41515.2
Theoretical pI
Not Available
GO Classification
Functions
enzyme binding / histone methyltransferase activity / histone methyltransferase activity (H4-R3 specific) / identical protein binding / methyltransferase activity / mitogen-activated protein kinase p38 binding / N-methyltransferase activity / poly(A) RNA binding / protein methyltransferase activity / protein-arginine N-methyltransferase activity / protein-arginine omega-N asymmetric methyltransferase activity
Processes
cell surface receptor signaling pathway / chromatin organization / histone H4-R3 methylation / histone methylation / negative regulation of megakaryocyte differentiation / neuron projection development / peptidyl-arginine methylation / peptidyl-arginine methylation, to asymmetrical-dimethyl arginine / positive regulation of erythrocyte differentiation / positive regulation of hemoglobin biosynthetic process / positive regulation of p38MAPK cascade / protein methylation / regulation of transcription, DNA-templated
Components
cytoplasm / cytosol / nucleoplasm / nucleus
General Function
Protein-arginine omega-n asymmetric methyltransferase activity
Specific Function
Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, PIAS1, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15 and EWS. Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 'Arg-4' (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation. Together with dimethylated PIAS1, represses STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway. Methylates FOXO1 and retains it in the nucleus increasing its transcriptional activity.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Nucleus
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ99873
UniProtKB Entry NameANM1_HUMAN
HGNC IDHGNC:5187
General References
  1. Scott HS, Antonarakis SE, Lalioti MD, Rossier C, Silver PA, Henry MF: Identification and characterization of two putative human arginine methyltransferases (HRMT1L1 and HRMT1L2). Genomics. 1998 Mar 15;48(3):330-40. [PubMed:9545638]
  2. Nikawa J, Nakano H, Ohi N: Structural and functional conservation of human and yeast HCP1 genes which can suppress the growth defect of the Saccharomyces cerevisiae ire15 mutant. Gene. 1996 May 24;171(1):107-11. [PubMed:8675017]
  3. Scorilas A, Black MH, Talieri M, Diamandis EP: Genomic organization, physical mapping, and expression analysis of the human protein arginine methyltransferase 1 gene. Biochem Biophys Res Commun. 2000 Nov 19;278(2):349-59. [PubMed:11097842]
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  8. Weiss VH, McBride AE, Soriano MA, Filman DJ, Silver PA, Hogle JM: The structure and oligomerization of the yeast arginine methyltransferase, Hmt1. Nat Struct Biol. 2000 Dec;7(12):1165-71. [PubMed:11101900]
  9. Strahl BD, Briggs SD, Brame CJ, Caldwell JA, Koh SS, Ma H, Cook RG, Shabanowitz J, Hunt DF, Stallcup MR, Allis CD: Methylation of histone H4 at arginine 3 occurs in vivo and is mediated by the nuclear receptor coactivator PRMT1. Curr Biol. 2001 Jun 26;11(12):996-1000. [PubMed:11448779]
  10. Wang H, Huang ZQ, Xia L, Feng Q, Erdjument-Bromage H, Strahl BD, Briggs SD, Allis CD, Wong J, Tempst P, Zhang Y: Methylation of histone H4 at arginine 3 facilitating transcriptional activation by nuclear hormone receptor. Science. 2001 Aug 3;293(5531):853-7. Epub 2001 May 31. [PubMed:11387442]
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  14. Miyata S, Mori Y, Tohyama M: PRMT1 and Btg2 regulates neurite outgrowth of Neuro2a cells. Neurosci Lett. 2008 Nov 14;445(2):162-5. doi: 10.1016/j.neulet.2008.08.065. Epub 2008 Aug 28. [PubMed:18773938]
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  21. Kaehler C, Guenther A, Uhlich A, Krobitsch S: PRMT1-mediated arginine methylation controls ATXN2L localization. Exp Cell Res. 2015 May 15;334(1):114-25. doi: 10.1016/j.yexcr.2015.02.022. Epub 2015 Mar 5. [PubMed:25748791]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB01752S-adenosyl-L-homocysteineexperimentalunknownDetails