HTH-type transcriptional regulator TtgR
Details
- Name
- HTH-type transcriptional regulator TtgR
- Synonyms
- Toluene efflux pump ttgABC operon repressor
- Gene Name
- ttgR
- Organism
- Pseudomonas putida (strain DOT-T1E)
- Amino acid sequence
>lcl|BSEQ0012850|HTH-type transcriptional regulator TtgR MVRRTKEEAQETRAQIIEAAERAFYKRGVARTTLADIAELAGVTRGAIYWHFNNKAELVQ ALLDSLHETHDHLARASESEDEVDPLGCMRKLLLQVFNELVLDARTRRINEILHHKCEFT DDMCEIRQQRQSAVLDCHKGITLALANAVRRGQLPGELDAERAAVAMFAYVDGLIRRWLL LPDSVDLLGDVEKWVDTGLDMLRLSPALRK
- Number of residues
- 210
- Molecular Weight
- 23854.075
- Theoretical pI
- 6.17
- GO Classification
- FunctionsDNA bindingProcessesregulation of transcription, DNA-templated / transcription, DNA-templated
- General Function
- Dna binding
- Specific Function
- Represses expression from the ttgABC operon promoter and its own expression. Binds to a promoter region between the divergently transcribed ttgR and ttgABC genes/operons; in the presence of chloramphenicol or tetracycline this binding no longer occurs and ttgR and ttgABC are derepressed. This suggests that TtgR binds these antibiotics.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasmic
- Gene sequence
>lcl|BSEQ0012851|HTH-type transcriptional regulator TtgR (ttgR) ATGGTCCGTCGAACCAAAGAAGAAGCCCAGGAAACCCGTGCCCAGATCATCGAGGCGGCG GAAAGGGCCTTCTACAAGCGCGGGGTTGCGCGAACCACCCTGGCCGACATCGCCGAACTG GCGGGTGTGACGCGGGGGGCGATCTACTGGCACTTCAACAACAAGGCCGAGCTGGTGCAG GCGTTGCTCGACAGCCTGCACGAGACCCATGACCATTTGGCGCGGGCGAGCGAAAGCGAG GATGAAGTCGACCCGCTTGGCTGCATGCGCAAGCTGCTGTTGCAAGTGTTCAACGAGCTG GTGCTCGATGCCCGAACCCGTCGTATCAATGAAATCCTGCATCACAAGTGCGAGTTCACC GATGACATGTGTGAAATTCGCCAGCAGCGCCAGAGTGCGGTGCTGGATTGCCACAAGGGC ATCACCCTGGCGCTGGCCAATGCCGTACGCCGGGGCCAGTTGCCTGGCGAGCTGGATGCC GAGCGCGCGGCGGTGGCCATGTTTGCCTATGTCGATGGCCTGATCAGGCGCTGGCTATTG CTGCCTGACAGTGTCGATCTGTTGGGTGATGTCGAAAAATGGGTCGACACCGGGCTGGAT ATGCTGCGCTTGAGCCCGGCTCTGCGCAAATGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q9AIU0 UniProtKB Entry Name TTGR_PSEPT GenBank Protein ID 13183097 GenBank Gene ID AF238479 - General References
- Duque E, Segura A, Mosqueda G, Ramos JL: Global and cognate regulators control the expression of the organic solvent efflux pumps TtgABC and TtgDEF of Pseudomonas putida. Mol Microbiol. 2001 Feb;39(4):1100-6. [Article]
- Udaondo Z, Molina L, Daniels C, Gomez MJ, Molina-Henares MA, Matilla MA, Roca A, Fernandez M, Duque E, Segura A, Ramos JL: Metabolic potential of the organic-solvent tolerant Pseudomonas putida DOT-T1E deduced from its annotated genome. Microb Biotechnol. 2013 Sep;6(5):598-611. doi: 10.1111/1751-7915.12061. Epub 2013 Jul 1. [Article]
- Teran W, Felipe A, Segura A, Rojas A, Ramos JL, Gallegos MT: Antibiotic-dependent induction of Pseudomonas putida DOT-T1E TtgABC efflux pump is mediated by the drug binding repressor TtgR. Antimicrob Agents Chemother. 2003 Oct;47(10):3067-72. [Article]