Ribonucleoside-diphosphate reductase subunit beta

Details

Name
Ribonucleoside-diphosphate reductase subunit beta
Synonyms
  • 1.17.4.1
  • Ribonucleotide reductase small subunit
Gene Name
nrdF
Organism
Mycobacterium leprae (strain TN)
Amino acid sequence
>lcl|BSEQ0012278|Ribonucleoside-diphosphate reductase subunit beta
MLTGKMKLIDRVSAINWNWLQDDKDAEVWDRLTGNFWLPEKVPVSNDLPSWGTLTASEKQ
LTMRVFTGLTLLDTIQGTVGAVSLIPDALTPHEEAVYTNIAFMESVHAKSYSSIFSTLCS
TAEIDEAFRWSEENNNLQRKAKIVMEYYRGDEPLKRKVASTLLESFLFYSGFYLPMYWSS
RAKLTNTADMIRLIIRDEAVHGYYIGYKFQRGLVLVDDARRAELKEYTYELLFELYDNEV
EYTQDLYDRVGLTEDVKKFLRYNANKALMNLGYEALFPRDETDVNPAILSALSPNADENH
DFFSGSGSSYVIGKAVVTEDEDWDF
Number of residues
325
Molecular Weight
37315.67
Theoretical pI
4.43
GO Classification
Functions
metal ion binding / ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
Processes
deoxyribonucleoside diphosphate metabolic process / deoxyribonucleotide biosynthetic process / DNA replication
Components
ribonucleoside-diphosphate reductase complex
General Function
Ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
Specific Function
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity).
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0012279|Ribonucleoside-diphosphate reductase subunit beta (nrdF)
TTGTTGACTGGGAAGATGAAGCTAATTGACCGCGTTTCGGCGATTAATTGGAACTGGCTG
CAAGACGACAAGGACGCCGAGGTCTGGGACCGGCTGACTGGAAACTTCTGGCTGCCCGAG
AAGGTGCCGGTGTCCAACGATCTCCCGTCGTGGGGCACGCTGACTGCTAGTGAAAAGCAG
CTGACAATGCGGGTGTTCACCGGTTTGACGCTGCTCGACACGATCCAAGGCACGGTCGGA
GCGGTCAGCCTTATTCCTGATGCGCTAACGCCGCATGAGGAAGCCGTCTACACCAACATT
GCATTCATGGAGTCGGTGCACGCCAAGAGCTACAGTTCGATCTTTTCCACGCTGTGCTCG
ACAGCGGAGATCGACGAAGCGTTTCGCTGGTCGGAGGAGAACAACAACCTGCAGCGCAAA
GCTAAGATTGTGATGGAGTACTATCGAGGCGACGAACCGCTCAAGCGCAAGGTGGCCTCC
ACCTTGCTCGAAAGCTTCCTGTTTTACTCTGGGTTCTACCTGCCGATGTACTGGTCAAGT
CGGGCCAAGCTGACCAACACCGCTGATATGATTCGGCTGATCATCCGCGACGAAGCAGTC
CACGGTTACTATATCGGCTACAAATTTCAGCGTGGCTTGGTGTTGGTCGACGACGCCAGG
CGGGCAGAACTCAAGGAATACACCTACGAATTGCTCTTTGAGCTCTACGACAACGAGGTG
GAATACACCCAAGATCTCTACGACAGAGTCGGGTTGACCGAAGACGTCAAGAAGTTCTTG
CGCTACAACGCAAATAAGGCGTTGATGAACCTTGGCTACGAGGCGCTGTTCCCGCGGGAC
GAGACCGACGTGAACCCGGCGATCCTGTCGGCCTTGTCTCCCAACGCCGATGAGAATCAT
GACTTTTTCTCCGGCTCGGGGTCGTCGTATGTGATCGGGAAAGCCGTCGTCACTGAGGAC
GAGGACTGGGACTTCTAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ9CBQ2
UniProtKB Entry NameRIR2_MYCLE
GenBank Gene IDAL583923
General References
  1. Cole ST, Eiglmeier K, Parkhill J, James KD, Thomson NR, Wheeler PR, Honore N, Garnier T, Churcher C, Harris D, Mungall K, Basham D, Brown D, Chillingworth T, Connor R, Davies RM, Devlin K, Duthoy S, Feltwell T, Fraser A, Hamlin N, Holroyd S, Hornsby T, Jagels K, Lacroix C, Maclean J, Moule S, Murphy L, Oliver K, Quail MA, Rajandream MA, Rutherford KM, Rutter S, Seeger K, Simon S, Simmonds M, Skelton J, Squares R, Squares S, Stevens K, Taylor K, Whitehead S, Woodward JR, Barrell BG: Massive gene decay in the leprosy bacillus. Nature. 2001 Feb 22;409(6823):1007-11. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB04272Citric acidapproved, nutraceutical, vet_approvedunknownDetails