Prostaglandin F synthase

Details

Name

Prostaglandin F synthase

Synonyms

• 1.1.1.188
• Prostaglandin F2-alpha synthase

Gene Name

Not Available

Organism

Trypanosoma brucei brucei

Amino acid sequence

>lcl|BSEQ0012186|Prostaglandin F synthase
MALTQSLKLSNGVMMPVLGFGMWKLQDGNEAETATMWAIKSGYRHIDTAAIYKNEESAGR
AIASCGVPREELFVTTKLWNSDQGYESTLSAFEKSIKKLGLEYVDLYLIHWPGKDKFIDT
WKAFEKLYADKKVRAIGVSNFHEHHIEELLKHCKVAPMVNQIELHPLLNQKALCEYCKSK
NIAVTAWSPLGQGHLVEDARLKAIGGKYGKTAAQVMLRWEIQAGVITIPKSGNEARIKEN
GNIFDFELTAEDIQVIDGMNAGHRYGPDPEVFMNDF

Number of residues

276

Molecular Weight

30992.385

Theoretical pI

6.79

GO Classification

Functions

nucleotide binding / prostaglandin D2 11-ketoreductase activity / prostaglandin-F synthase activity

Processes

prostaglandin biosynthetic process

Components

cytoplasm

General Function

Prostaglandin-f synthase activity

Specific Function

Catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. Has also aldo/ketoreductase activity towards the synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde.

Pfam Domain Function

• Aldo_ket_red (PF00248)

Transmembrane Regions

Not Available

Cellular Location

Cytoplasm

Gene sequence

>lcl|BSEQ0006091|831 bp
ATGGCTCTCACTCAATCCCTAAAACTCTCGAATGGAGTGATGATGCCAGTTCTTGGTTTC
GGTATGTGGAAGTTACAGGATGGCAATGAAGCCGAGACGGCGACGATGTGGGCCATAAAA
AGCGGCTATCGTCACATCGATACTGCAGCCATCTATAAAAATGAAGAAAGCGCTGGCAGA
GCCATTGCCTCATGTGGTGTACCGCGGGAAGAGCTATTCGTCACGACGAAGCTTTGGAAC
TCCGACCAGGGATATGAGAGCACGCTGAGCGCATTTGAGAAGAGCATTAAGAAGCTCGGC
CTGGAATATGTTGACCTATACCTCATCCACTGGCCGGGGAAGGACAAGTTTATCGACACA
TGGAAGGCGTTTGAGAAACTGTACGCCGATAAGAAGGTGCGCGCCATTGGCGTTTCCAAC
TTTCACGAGCACCACATCGAGGAACTGCTAAAGCACTGTAAGGTTGCACCGATGGTTAAC
CAGATCGAGCTCCATCCGCTGCTCAATCAGAAGGCACTCTGCGAGTACTGCAAGTCGAAG
AACATCGCCGTCACTGCCTGGTCGCCGCTTGGTCAAGGACATCTCGTCGAAGACGCCCGT
CTGAAAGCTATCGGAGGAAAGTATGGTAAGACAGCTGCGCAGGTGATGCTCCGCTGGGAA
ATACAAGCAGGGGTCATCACGATTCCCAAATCGGGCAACGAGGCCCGCATCAAGGAAAAT
GGCAATATATTTGACTTCGAACTAACTGCGGAGGACATTCAAGTCATCGATGGTATGAAT
GCCGGCCACCGCTACGGCCCCGATCCGGAGGTCTTCATGAACGACTTTTGA

Chromosome Location

Not Available

Locus

Not Available

External Identifiers

Resource	Link
UniProtKB ID	Q9GV41
UniProtKB Entry Name	PGFS_TRYBB
GenBank Gene ID	AB034727

General References

1. Kubata BK, Duszenko M, Kabututu Z, Rawer M, Szallies A, Fujimori K, Inui T, Nozaki T, Yamashita K, Horii T, Urade Y, Hayaishi O: Identification of a novel prostaglandin f(2alpha) synthase in Trypanosoma brucei. J Exp Med. 2000 Nov 6;192(9):1327-38. [Article]

Drug Relations

Drug Relations

DrugBank ID	Name	Drug group	Pharmacological action?	Actions	Details
DB03461	Nicotinamide adenine dinucleotide phosphate	experimental	unknown		Details
DB04272	Citric acid	approved, nutraceutical, vet_approved	unknown		Details