ATP-binding cassette sub-family G member 5
Details
- Name
- ATP-binding cassette sub-family G member 5
- Synonyms
- Sterolin-1
- Gene Name
- ABCG5
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0008599|ATP-binding cassette sub-family G member 5 MGDLSSLTPGGSMGLQVNRGSQSSLEGAPATAPEPHSLGILHASYSVSHRVRPWWDITSC RQQWTRQILKDVSLYVESGQIMCILGSSGSGKTTLLDAMSGRLGRAGTFLGEVYVNGRAL RREQFQDCFSYVLQSDTLLSSLTVRETLHYTALLAIRRGNPGSFQKKVEAVMAELSLSHV ADRLIGNYSLGGISTGERRRVSIAAQLLQDPKVMLFDEPTTGLDCMTANQIVVLLVELAR RNRIVVLTIHQPRSELFQLFDKIAILSFGELIFCGTPAEMLDFFNDCGYPCPEHSNPFDF YMDLTSVDTQSKEREIETSKRVQMIESAYKKSAICHKTLKNIERMKHLKTLPMVPFKTKD SPGVFSKLGVLLRRVTRNLVRNKLAVITRLLQNLIMGLFLLFFVLRVRSNVLKGAIQDRV GLLYQFVGATPYTGMLNAVNLFPVLRAVSDQESQDGLYQKWQMMLAYALHVLPFSVVATM IFSSVCYWTLGLHPEVARFGYFSAALLAPHLIGEFLTLVLLGIVQNPNIVNSVVALLSIA GVLVGSGFLRNIQEMPIPFKIISYFTFQKYCSEILVVNEFYGLNFTCGSSNVSVTTNPMC AFTQGIQFIEKTCPGATSRFTMNFLILYSFIPALVILGIVVFKIRDHLISR
- Number of residues
- 651
- Molecular Weight
- 72503.02
- Theoretical pI
- Not Available
- GO Classification
- FunctionsATP binding / ATPase activity, coupled to transmembrane movement of substances / protein heterodimerization activityProcessescholesterol efflux / cholesterol homeostasis / excretion / intestinal cholesterol absorption / negative regulation of intestinal cholesterol absorption / negative regulation of intestinal phytosterol absorption / response to drug / response to ionizing radiation / response to nutrient / small molecule metabolic process / sterol transport / transmembrane transportComponentsapical plasma membrane / ATP-binding cassette (ABC) transporter complex / plasma membrane / receptor complex
- General Function
- Protein heterodimerization activity
- Specific Function
- Transporter that appears to play an indispensable role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile.
- Pfam Domain Function
- Transmembrane Regions
- 384-404 422-442 463-483 504-524 529-549 624-644
- Cellular Location
- Membrane
- Gene sequence
>lcl|BSEQ0013296|ATP-binding cassette sub-family G member 5 (ABCG5) ATGGGTGACCTCTCATCTTTGACCCCCGGAGGGTCCATGGGTCTCCAAGTAAACAGAGGC TCCCAGAGCTCCCTGGAGGGGGCTCCTGCCACCGCCCCGGAGCCTCACAGCCTGGGCATC CTCCATGCCTCCTACAGCGTCAGCCACCGCGTGAGGCCCTGGTGGGACATCACATCTTGC CGGCAGCAGTGGACCAGGCAGATCCTCAAAGATGTCTCCTTGTACGTGGAGAGCGGGCAG ATCATGTGCATCCTAGGAAGCTCAGGCTCCGGGAAAACCACGCTGCTGGACGCCATGTCC GGGAGGCTGGGGCGCGCGGGGACCTTCCTGGGGGAGGTGTATGTGAACGGCCGGGCGCTG CGCCGGGAGCAGTTCCAGGACTGCTTCTCCTACGTCCTGCAGAGCGACACCCTGCTGAGC AGCCTCACCGTGCGCGAGACGCTGCACTACACCGCGCTGCTGGCCATCCGCCGCGGCAAT CCCGGCTCCTTCCAGAAGAAGGTGGAGGCCGTCATGGCAGAGCTGAGTCTGAGCCATGTG GCAGACCGACTGATTGGCAACTACAGCTTGGGGGGCATTTCCACGGGTGAGCGGCGCCGG GTCTCCATCGCAGCCCAGCTGCTCCAGGATCCTAAGGTCATGCTGTTTGATGAGCCAACC ACAGGCCTGGACTGCATGACTGCTAATCAGATTGTCGTCCTCCTGGTGGAACTGGCTCGC AGGAACCGAATTGTGGTTCTCACCATTCACCAGCCCCGTTCTGAGCTTTTTCAGCTCTTT GACAAAATTGCCATCCTGAGCTTCGGAGAGCTGATTTTCTGTGGCACGCCAGCGGAAATG CTTGATTTCTTCAATGACTGCGGTTACCCTTGTCCTGAACATTCAAACCCTTTTGACTTC TATATGGACCTGACGTCAGTGGATACCCAAAGCAAGGAACGGGAAATAGAAACCTCCAAG AGAGTCCAGATGATAGAATCTGCCTACAAGAAATCAGCAATTTGTCATAAAACTTTGAAG AATATTGAAAGAATGAAACACCTGAAAACGTTACCAATGGTTCCTTTCAAAACCAAAGAT TCTCCTGGAGTTTTCTCTAAACTGGGTGTTCTCCTGAGGAGAGTGACAAGAAACTTGGTG AGAAATAAGCTGGCAGTGATTACGCGTCTCCTTCAGAATCTGATCATGGGTTTGTTCCTC CTTTTCTTCGTTCTGCGGGTCCGAAGCAATGTGCTAAAGGGTGCTATCCAGGACCGCGTA GGTCTCCTTTACCAGTTTGTGGGCGCCACCCCGTACACAGGCATGCTGAACGCTGTGAAT CTGTTTCCCGTGCTGCGAGCTGTCAGCGACCAGGAGAGTCAGGACGGCCTCTACCAGAAG TGGCAGATGATGCTGGCCTATGCACTGCACGTCCTCCCCTTCAGCGTTGTTGCCACCATG ATTTTCAGCAGTGTGTGCTACTGGACGCTGGGCTTACATCCTGAGGTTGCCCGATTTGGA TATTTTTCTGCTGCTCTCTTGGCCCCCCACTTAATTGGTGAATTTCTAACTCTTGTGCTA CTTGGTATCGTCCAAAATCCAAATATAGTCAACAGTGTAGTGGCTCTGCTGTCCATTGCG GGGGTGCTTGTTGGATCTGGATTCCTCAGAAACATACAAGAAATGCCCATTCCTTTTAAA ATCATCAGTTATTTTACATTCCAAAAATATTGCAGTGAGATTCTTGTAGTCAATGAGTTC TACGGACTGAATTTCACTTGTGGCAGCTCAAATGTTTCTGTGACAACTAATCCAATGTGT GCCTTCACTCAAGGAATTCAATTCATTGAGAAAACCTGCCCAGGTGCAACATCTAGATTC ACAATGAACTTTCTGATTTTGTATTCATTTATTCCAGCTCTTGTCATCCTAGGAATAGTT GTTTTCAAAATAAGGGATCATCTCATTAGCAGGTAG
- Chromosome Location
- 2
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q9H222 UniProtKB Entry Name ABCG5_HUMAN HGNC ID HGNC:13886 - General References
- Berge KE, Tian H, Graf GA, Yu L, Grishin NV, Schultz J, Kwiterovich P, Shan B, Barnes R, Hobbs HH: Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters. Science. 2000 Dec 1;290(5497):1771-5. [Article]
- Lee MH, Lu K, Hazard S, Yu H, Shulenin S, Hidaka H, Kojima H, Allikmets R, Sakuma N, Pegoraro R, Srivastava AK, Salen G, Dean M, Patel SB: Identification of a gene, ABCG5, important in the regulation of dietary cholesterol absorption. Nat Genet. 2001 Jan;27(1):79-83. [Article]
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- Schmitz G, Langmann T, Heimerl S: Role of ABCG1 and other ABCG family members in lipid metabolism. J Lipid Res. 2001 Oct;42(10):1513-20. [Article]
- Hubacek JA, Berge KE, Cohen JC, Hobbs HH: Mutations in ATP-cassette binding proteins G5 (ABCG5) and G8 (ABCG8) causing sitosterolemia. Hum Mutat. 2001 Oct;18(4):359-60. [Article]