Potassium voltage-gated channel subfamily F member 1

Details

Name

Potassium voltage-gated channel subfamily F member 1

Synonyms

• kH1
• Voltage-gated potassium channel subunit Kv5.1

Gene Name

KCNF1

Organism

Humans

Amino acid sequence

>lcl|BSEQ0052273|Potassium voltage-gated channel subfamily F member 1
MDGSGERSLPEPGSQSSAASDDIEIVVNVGGVRQVLYGDLLSQYPETRLAELINCLAGGY
DTIFSLCDDYDPGKREFYFDRDPDAFKCVIEVYYFGEVHMKKGICPICFKNEMDFWKVDL
KFLDDCCKSHLSEKREELEEIARRVQLILDDLGVDAAEGRWRRCQKCVWKFLEKPESSCP
ARVVAVLSFLLILVSSVVMCMGTIPELQVLDAEGNRVEHPTLENVETACIGWFTLEYLLR
LFSSPNKLHFALSFMNIVDVLAILPFYVSLTLTHLGARMMELTNVQQAVQALRIMRIARI
FKLARHSSGLQTLTYALKRSFKELGLLLMYLAVGIFVFSALGYTMEQSHPETLFKSIPQS
FWWAIITMTTVGYGDIYPKTTLGKLNAAISFLCGVIAIALPIHPIINNFVRYYNKQRVLE
TAAKHELELMELNSSSGGEGKTGGSRSDLDNLPPEPAGKEAPSCSSRLKLSHSDTFIPLL
TEEKHHRTRLQSCK

Number of residues

494

Molecular Weight

55583.755

Theoretical pI

Not Available

GO Classification

Functions

potassium channel activity / voltage-gated potassium channel activity

Processes

potassium ion transmembrane transport / potassium ion transport / protein homooligomerization / regulation of ion transmembrane transport

Components

integral component of membrane / plasma membrane / voltage-gated potassium channel complex

General Function

Putative voltage-gated potassium channel.

Specific Function

Potassium channel activity

Pfam Domain Function

• Ion_trans (PF00520)
• BTB_2 (PF02214)

Transmembrane Regions

184-204 224-244 250-270 290-310 325-345 386-406

Cellular Location

Membrane

Gene sequence

>lcl|BSEQ0052274|Potassium voltage-gated channel subfamily F member 1 (KCNF1)
ATGGACGGGTCCGGGGAGCGCAGCCTCCCGGAGCCGGGCAGCCAGAGCTCCGCTGCCAGC
GACGACATAGAGATAGTCGTCAACGTGGGGGGCGTGCGGCAGGTGCTGTACGGGGACCTC
CTCAGTCAGTACCCTGAGACCCGGCTGGCGGAGCTCATCAACTGCTTGGCTGGGGGCTAC
GACACCATCTTCTCCCTGTGCGACGACTACGACCCCGGCAAGCGCGAGTTCTACTTTGAC
AGGGACCCGGACGCCTTCAAGTGTGTCATCGAGGTGTACTATTTCGGGGAGGTCCACATG
AAGAAGGGCATCTGCCCCATCTGCTTCAAGAACGAGATGGACTTCTGGAAGGTGGACCTC
AAGTTCCTGGACGACTGTTGCAAGAGCCACCTGAGCGAGAAGCGCGAGGAGCTGGAGGAG
ATCGCGCGCCGCGTGCAGCTCATCCTGGACGACCTGGGCGTGGACGCAGCCGAGGGCCGC
TGGCGCCGCTGCCAGAAGTGCGTCTGGAAGTTCCTGGAGAAGCCCGAGTCGTCGTGCCCG
GCGCGGGTGGTGGCCGTGCTCTCCTTCCTGCTCATCCTCGTCTCGTCCGTGGTCATGTGC
ATGGGCACCATCCCCGAGCTGCAGGTGCTGGACGCCGAGGGCAACCGCGTGGAGCACCCG
ACGCTGGAGAACGTGGAGACGGCGTGCATTGGCTGGTTCACCCTGGAGTACCTGCTGCGC
CTCTTCTCGTCACCCAACAAGCTGCACTTCGCGCTGTCCTTCATGAACATTGTGGACGTG
CTGGCCATCCTCCCCTTCTACGTGAGCCTCACGCTCACGCACCTGGGTGCCCGCATGATG
GAGCTGACCAACGTGCAGCAGGCCGTGCAGGCGCTGCGGATCATGCGCATCGCGCGCATC
TTCAAGCTGGCCCGCCACTCCTCGGGCCTGCAGACCCTCACCTATGCCCTCAAGCGCAGC
TTCAAGGAACTGGGGCTGCTGCTCATGTACCTGGCAGTGGGTATCTTCGTCTTCTCTGCC
CTGGGCTACACCATGGAGCAGAGCCATCCAGAGACCCTGTTTAAGAGCATCCCCCAGTCC
TTCTGGTGGGCCATCATCACCATGACCACCGTCGGCTACGGCGACATCTACCCCAAGACC
ACGCTGGGCAAGCTCAACGCGGCCATCAGCTTCTTGTGTGGTGTCATCGCCATCGCCCTG
CCCATCCACCCCATCATCAACAACTTTGTCAGGTACTACAACAAGCAGCGCGTCCTGGAG
ACCGCGGCCAAGCACGAGCTGGAGCTGATGGAACTCAACTCCAGCAGCGGGGGCGAGGGC
AAGACCGGGGGCTCCCGCAGTGACCTGGACAACCTCCCTCCAGAGCCTGCGGGGAAGGAG
GCGCCGAGCTGCAGCAGCCGGCTGAAGCTCTCCCACAGCGACACCTTCATCCCCCTCCTG
ACCGAGGAGAAGCACCACAGGACCCGGCTCCAGAGTTGCAAGTGA

Chromosome Location

2

Locus

2p25.1

External Identifiers

Resource	Link
UniProtKB ID	Q9H3M0
UniProtKB Entry Name	KCNF1_HUMAN
HGNC ID	HGNC:6246

General References

1. Su K, Kyaw H, Fan P, Zeng Z, Shell BK, Carter KC, Li Y: Isolation, characterization, and mapping of two human potassium channels. Biochem Biophys Res Commun. 1997 Dec 29;241(3):675-81. [Article]
2. Hillier LW, Graves TA, Fulton RS, Fulton LA, Pepin KH, Minx P, Wagner-McPherson C, Layman D, Wylie K, Sekhon M, Becker MC, Fewell GA, Delehaunty KD, Miner TL, Nash WE, Kremitzki C, Oddy L, Du H, Sun H, Bradshaw-Cordum H, Ali J, Carter J, Cordes M, Harris A, Isak A, van Brunt A, Nguyen C, Du F, Courtney L, Kalicki J, Ozersky P, Abbott S, Armstrong J, Belter EA, Caruso L, Cedroni M, Cotton M, Davidson T, Desai A, Elliott G, Erb T, Fronick C, Gaige T, Haakenson W, Haglund K, Holmes A, Harkins R, Kim K, Kruchowski SS, Strong CM, Grewal N, Goyea E, Hou S, Levy A, Martinka S, Mead K, McLellan MD, Meyer R, Randall-Maher J, Tomlinson C, Dauphin-Kohlberg S, Kozlowicz-Reilly A, Shah N, Swearengen-Shahid S, Snider J, Strong JT, Thompson J, Yoakum M, Leonard S, Pearman C, Trani L, Radionenko M, Waligorski JE, Wang C, Rock SM, Tin-Wollam AM, Maupin R, Latreille P, Wendl MC, Yang SP, Pohl C, Wallis JW, Spieth J, Bieri TA, Berkowicz N, Nelson JO, Osborne J, Ding L, Meyer R, Sabo A, Shotland Y, Sinha P, Wohldmann PE, Cook LL, Hickenbotham MT, Eldred J, Williams D, Jones TA, She X, Ciccarelli FD, Izaurralde E, Taylor J, Schmutz J, Myers RM, Cox DR, Huang X, McPherson JD, Mardis ER, Clifton SW, Warren WC, Chinwalla AT, Eddy SR, Marra MA, Ovcharenko I, Furey TS, Miller W, Eichler EE, Bork P, Suyama M, Torrents D, Waterston RH, Wilson RK: Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Nature. 2005 Apr 7;434(7034):724-31. [Article]
3. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
4. Godreau D, Vranckx R, Maguy A, Rucker-Martin C, Goyenvalle C, Abdelshafy S, Tessier S, Couetil JP, Hatem SN: Expression, regulation and role of the MAGUK protein SAP-97 in human atrial myocardium. Cardiovasc Res. 2002 Dec;56(3):433-42. [Article]

Drug Relations

Drug Relations

DrugBank ID	Name	Drug group	Pharmacological action?	Actions	Details
DB00228	Enflurane	approved, investigational, vet_approved	unknown	inhibitoractivator	Details
DB01069	Promethazine	approved, investigational	unknown	inducer	Details
DB01110	Miconazole	approved, investigational, vet_approved	unknown	inhibitor	Details