Magnesium transporter MRS2 homolog, mitochondrial

Details

Name

Magnesium transporter MRS2 homolog, mitochondrial

Synonyms

• HPT
• MRS2-like protein
• MRS2L

Gene Name

MRS2

Organism

Humans

Amino acid sequence

>lcl|BSEQ0052298|Magnesium transporter MRS2 homolog, mitochondrial
MECLRSLPCLLPRAMRLPRRTLCALALDVTSVGPPVAACGRRANLIGRSRAAQLCGPDRL
RVAGEVHRFRTSDVSQATLASVAPVFTVTKFDKQGNVTSFERKKTELYQELGLQARDLRF
QHVMSITVRNNRIIMRMEYLKAVITPECLLILDYRNLNLEQWLFRELPSQLSGEGQLVTY
PLPFEFRAIEALLQYWINTLQGKLSILQPLILETLDALVDPKHSSVDRSKLHILLQNGKS
LSELETDIKIFKESILEILDEEELLEELCVSKWSDPQVFEKSSAGIDHAEEMELLLENYY
RLADDLSNAARELRVLIDDSQSIIFINLDSHRNVMMRLNLQLTMGTFSLSLFGLMGVAFG
MNLESSLEEDHRIFWLITGIMFMGSGLIWRRLLSFLGRQLEAPLPPMMASLPKKTLLADR
SMELKNSLRLDGLGSGRSILTNR

Number of residues

443

Molecular Weight

50317.01

Theoretical pI

Not Available

GO Classification

Functions

magnesium ion transmembrane transporter activity

Processes

lactate metabolic process / magnesium ion transport / mitochondrial magnesium ion transmembrane transport / transmembrane transport

Components

integral component of membrane / mitochondrial inner membrane / mitochondrion

General Function

Magnesium transporter that mediates the influx of magnesium into the mitochondrial matrix (PubMed:11401429, PubMed:18384665). Required for normal expression of the mitochondrial respiratory complex I subunits (PubMed:18384665).

Specific Function

Magnesium ion transmembrane transporter activity

Pfam Domain Function

Not Available

Transmembrane Regions

340-360 373-393

Cellular Location

Mitochondrion inner membrane

Gene sequence

>lcl|BSEQ0052299|Magnesium transporter MRS2 homolog, mitochondrial (MRS2)
ATGGAATGCCTGCGCAGTTTACCCTGCCTCCTGCCCCGCGCGATGAGACTTCCCCGGCGG
ACGCTGTGTGCCCTGGCCTTGGACGTGACCTCTGTGGGTCCTCCCGTTGCTGCCTGCGGC
CGCCGAGCCAACCTGATTGGAAGGAGCCGAGCGGCGCAGCTTTGCGGGCCCGACCGGCTC
CGCGTGGCAGGTGAAGTGCACCGGTTTAGAACCTCTGACGTCTCTCAAGCCACTTTAGCC
AGTGTAGCCCCAGTATTTACTGTGACAAAATTTGACAAACAGGGAAACGTTACTTCTTTT
GAAAGGAAGAAAACTGAATTATACCAAGAGTTAGGTCTTCAAGCCAGAGATTTGAGATTT
CAGCATGTAATGAGTATCACAGTCAGAAACAATAGGATTATCATGAGAATGGAGTATTTG
AAAGCTGTGATAACTCCAGAGTGTCTTCTGATATTAGATTATCGTAATTTAAACTTAGAG
CAATGGCTGTTCCGGGAACTCCCTTCACAGTTGTCTGGAGAGGGTCAACTCGTTACATAC
CCTTTACCTTTTGAGTTTAGAGCTATAGAAGCACTCCTGCAATATTGGATCAACACCCTT
CAGGGGAAACTTAGCATTTTGCAGCCACTGATCCTTGAGACCTTGGATGCTTTGGTGGAC
CCCAAACATTCTTCTGTAGACAGAAGCAAACTGCACATTTTACTACAGAATGGCAAAAGT
CTATCAGAGTTAGAAACAGATATTAAAATTTTCAAAGAGTCAATTTTGGAGATCTTGGAT
GAGGAAGAGTTGCTAGAAGAGCTCTGTGTATCAAAATGGAGTGACCCACAAGTCTTTGAA
AAGAGCAGTGCTGGGATTGACCATGCAGAAGAGATGGAGTTGCTGTTGGAAAACTACTAC
CGATTGGCTGACGATCTCTCCAATGCAGCTCGTGAGCTTAGGGTGCTGATTGATGATTCA
CAAAGTATTATTTTCATTAATCTGGACAGCCACCGAAACGTGATGATGAGGTTGAATCTA
CAGCTGACCATGGGAACCTTCTCTCTTTCGCTCTTTGGACTAATGGGAGTTGCTTTTGGA
ATGAATTTGGAATCTTCCCTTGAAGAGGACCATAGAATTTTTTGGCTGATTACAGGAATT
ATGTTCATGGGAAGTGGCCTCATCTGGAGGCGCCTGCTTTCATTCCTTGGACGACAGCTA
GAAGCTCCATTGCCTCCTATGATGGCTTCTTTACCTAAAAAGACTCTTCTGGCAGATAGA
AGCATGGAATTGAAAAATAGCCTCAGACTGGATGGACTTGGATCAGGAAGGAGCATCCTA
ACAAACCGTTAG

Chromosome Location

6

Locus

6p22.3

External Identifiers

Resource	Link
UniProtKB ID	Q9HD23
UniProtKB Entry Name	MRS2_HUMAN
HGNC ID	HGNC:13785

General References

1. Zsurka G, Gregan J, Schweyen RJ: The human mitochondrial Mrs2 protein functionally substitutes for its yeast homologue, a candidate magnesium transporter. Genomics. 2001 Mar 1;72(2):158-68. [Article]
2. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
3. Mungall AJ, Palmer SA, Sims SK, Edwards CA, Ashurst JL, Wilming L, Jones MC, Horton R, Hunt SE, Scott CE, Gilbert JG, Clamp ME, Bethel G, Milne S, Ainscough R, Almeida JP, Ambrose KD, Andrews TD, Ashwell RI, Babbage AK, Bagguley CL, Bailey J, Banerjee R, Barker DJ, Barlow KF, Bates K, Beare DM, Beasley H, Beasley O, Bird CP, Blakey S, Bray-Allen S, Brook J, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J, Carder C, Carter NP, Chapman JC, Clark SY, Clark G, Clee CM, Clegg S, Cobley V, Collier RE, Collins JE, Colman LK, Corby NR, Coville GJ, Culley KM, Dhami P, Davies J, Dunn M, Earthrowl ME, Ellington AE, Evans KA, Faulkner L, Francis MD, Frankish A, Frankland J, French L, Garner P, Garnett J, Ghori MJ, Gilby LM, Gillson CJ, Glithero RJ, Grafham DV, Grant M, Gribble S, Griffiths C, Griffiths M, Hall R, Halls KS, Hammond S, Harley JL, Hart EA, Heath PD, Heathcott R, Holmes SJ, Howden PJ, Howe KL, Howell GR, Huckle E, Humphray SJ, Humphries MD, Hunt AR, Johnson CM, Joy AA, Kay M, Keenan SJ, Kimberley AM, King A, Laird GK, Langford C, Lawlor S, Leongamornlert DA, Leversha M, Lloyd CR, Lloyd DM, Loveland JE, Lovell J, Martin S, Mashreghi-Mohammadi M, Maslen GL, Matthews L, McCann OT, McLaren SJ, McLay K, McMurray A, Moore MJ, Mullikin JC, Niblett D, Nickerson T, Novik KL, Oliver K, Overton-Larty EK, Parker A, Patel R, Pearce AV, Peck AI, Phillimore B, Phillips S, Plumb RW, Porter KM, Ramsey Y, Ranby SA, Rice CM, Ross MT, Searle SM, Sehra HK, Sheridan E, Skuce CD, Smith S, Smith M, Spraggon L, Squares SL, Steward CA, Sycamore N, Tamlyn-Hall G, Tester J, Theaker AJ, Thomas DW, Thorpe A, Tracey A, Tromans A, Tubby B, Wall M, Wallis JM, West AP, White SS, Whitehead SL, Whittaker H, Wild A, Willey DJ, Wilmer TE, Wood JM, Wray PW, Wyatt JC, Young L, Younger RM, Bentley DR, Coulson A, Durbin R, Hubbard T, Sulston JE, Dunham I, Rogers J, Beck S: The DNA sequence and analysis of human chromosome 6. Nature. 2003 Oct 23;425(6960):805-11. [Article]
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5. Piskacek M, Zotova L, Zsurka G, Schweyen RJ: Conditional knockdown of hMRS2 results in loss of mitochondrial Mg(2+) uptake and cell death. J Cell Mol Med. 2009 Apr;13(4):693-700. doi: 10.1111/j.1582-4934.2008.00328.x. Epub 2008 Mar 31. [Article]
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Drug Relations

Drug Relations

DrugBank ID	Name	Drug group	Pharmacological action?	Actions	Details
DB14513	Magnesium	approved, experimental, investigational	unknown		Details