3-methyl-2-oxobutanoate hydroxymethyltransferase
Details
- Name
- 3-methyl-2-oxobutanoate hydroxymethyltransferase
- Synonyms
- 2.1.2.11
- Ketopantoate hydroxymethyltransferase
- KPHMT
- Gene Name
- panB
- Organism
- Neisseria meningitidis serogroup B (strain MC58)
- Amino acid sequence
>lcl|BSEQ0011305|3-methyl-2-oxobutanoate hydroxymethyltransferase MITVNTLQKMKAAGEKIAMLTAYESSFAALMDDAGVEMLLVGDSLGMAVQGRKSTLPVSL RDMCYHTECVARGAKNAMIVSDLPFGAYQQSKEQAFAAAAELMAAGAHMVKLEGGVWMAE TTEFLQMRGIPVCAHIGLTPQSVFAFGGYKVQGRGGKAQALLNDAKAHDDAGAAVVLMEC VLAELAKKVTETVSCPTIGIGAGADCDGQVLVMHDMLGIFPGKTAKFVKNFMQGHDSVQA AVRAYVAEVKAKTFPAAEHIFAD
- Number of residues
- 263
- Molecular Weight
- 27739.07
- Theoretical pI
- 6.39
- GO Classification
- Functions3-methyl-2-oxobutanoate hydroxymethyltransferase activity / metal ion bindingProcessespantothenate biosynthetic processComponentscytoplasm
- General Function
- Metal ion binding
- Specific Function
- Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate.
- Pfam Domain Function
- Pantoate_transf (PF02548)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0011306|3-methyl-2-oxobutanoate hydroxymethyltransferase (panB) ATGATTACTGTGAACACACTGCAAAAAATGAAGGCGGCGGGCGAAAAAATCGCTATGCTG ACCGCTTACGAATCCAGTTTTGCCGCGCTGATGGACGATGCCGGCGTGGAAATGCTGCTG GTCGGCGATTCTTTGGGGATGGCGGTTCAGGGGCGGAAATCGACGCTGCCCGTCAGCCTG CGCGATATGTGTTATCACACCGAATGTGTAGCACGCGGTGCAAAAAATGCGATGATTGTC AGCGATTTGCCGTTTGGTGCATATCAGCAGAGTAAGGAGCAGGCGTTTGCCGCCGCCGCC GAACTGATGGCTGCCGGCGCGCATATGGTTAAACTCGAAGGCGGCGTGTGGATGGCGGAA ACGACTGAATTTTTGCAAATGCGCGGTATTCCGGTTTGTGCGCACATCGGTCTGACCCCG CAATCCGTGTTTGCCTTCGGCGGATATAAAGTTCAGGGGCGCGGCGGCAAGGCGCAGGCG TTGCTTAACGATGCCAAGGCGCATGACGATGCGGGGGCGGCGGTCGTGCTGATGGAGTGC GTACTGGCGGAACTGGCAAAAAAGGTAACTGAAACTGTTTCCTGTCCGACCATCGGCATC GGCGCGGGTGCGGATTGCGACGGGCAGGTTTTGGTGATGCACGATATGCTCGGCATTTTC CCGGGTAAGACGGCGAAATTCGTCAAAAACTTTATGCAGGGGCATGATAGTGTTCAAGCG GCGGTTCGGGCGTATGTTGCCGAAGTCAAAGCCAAAACCTTCCCTGCTGCGGAACATATT TTTGCAGATTGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q9JZW6 UniProtKB Entry Name PANB_NEIMB GenBank Protein ID 7226107 GenBank Gene ID AE002098 - General References
- Tettelin H, Saunders NJ, Heidelberg J, Jeffries AC, Nelson KE, Eisen JA, Ketchum KA, Hood DW, Peden JF, Dodson RJ, Nelson WC, Gwinn ML, DeBoy R, Peterson JD, Hickey EK, Haft DH, Salzberg SL, White O, Fleischmann RD, Dougherty BA, Mason T, Ciecko A, Parksey DS, Blair E, Cittone H, Clark EB, Cotton MD, Utterback TR, Khouri H, Qin H, Vamathevan J, Gill J, Scarlato V, Masignani V, Pizza M, Grandi G, Sun L, Smith HO, Fraser CM, Moxon ER, Rappuoli R, Venter JC: Complete genome sequence of Neisseria meningitidis serogroup B strain MC58. Science. 2000 Mar 10;287(5459):1809-15. [Article]
- Badger J, Sauder JM, Adams JM, Antonysamy S, Bain K, Bergseid MG, Buchanan SG, Buchanan MD, Batiyenko Y, Christopher JA, Emtage S, Eroshkina A, Feil I, Furlong EB, Gajiwala KS, Gao X, He D, Hendle J, Huber A, Hoda K, Kearins P, Kissinger C, Laubert B, Lewis HA, Lin J, Loomis K, Lorimer D, Louie G, Maletic M, Marsh CD, Miller I, Molinari J, Muller-Dieckmann HJ, Newman JM, Noland BW, Pagarigan B, Park F, Peat TS, Post KW, Radojicic S, Ramos A, Romero R, Rutter ME, Sanderson WE, Schwinn KD, Tresser J, Winhoven J, Wright TA, Wu L, Xu J, Harris TJ: Structural analysis of a set of proteins resulting from a bacterial genomics project. Proteins. 2005 Sep 1;60(4):787-96. [Article]