Acetylcholine receptor subunit alpha-type unc-63

Details

Name

Acetylcholine receptor subunit alpha-type unc-63

Synonyms

• lev-7
• Levamisole-resistant protein 7
• Uncoordinated protein 63

Gene Name

unc-63

Organism

Caenorhabditis elegans

Amino acid sequence

>lcl|BSEQ0013366|Acetylcholine receptor subunit alpha-type unc-63
MGPNDHGFAYILIFLLLSPPTHANRDANRLFEDLIADYNKLVRPVSENGETLVVTFKLKL
SQLLDVHEKNQIMTTNVWLQHSWMDYKLRWDPVEYGGVEVLYVPSDTIWLPDVVLYNNAD
GNYQVTIMTKAKLTYNGTVEWAPPAIYKSMCQIDVEFFPFDRQQCEMKFGSWTYGGLEVD
LQHRDKHLEKEIEEDVEGVDGPTKEIVWVVDRGIDLSDYYPSVEWDILNVPGKRHSKRYP
CCESPFIDITYEIHLRRKTLFYTVNLIFPSVGISFLTALVFYLPSDGGEKISLCISILIS
LTVFFLLLVEIIPSTSLVIPLIGKYLLFTMVLVTLSVVVTVVTLNVHYRSPTTHTMPKWM
KRLFVDFLPKYLLMTRPQPPGHHSKPNRKFDSRASTFSIGVNHVLGQNSELLSPGLNSNR
EESSFTLPRDNSPVRSAVESVAYIADHLKNEEDDKQVIEDWKYISVVMDRIFLITFTFAC
AFGTVVIIARAPSIYDNTPALA

Number of residues

502

Molecular Weight

57390.645

Theoretical pI

Not Available

GO Classification

Functions

acetylcholine-activated cation-selective channel activity / acetylcholine-gated cation channel activity

Processes

calcium ion import across plasma membrane / cation transmembrane transport / ion transmembrane transport / locomotion / neurological system process / neuromuscular synaptic transmission / post-embryonic development / regulation of locomotion / regulation of membrane potential / regulation of oviposition / response to nicotine / signal transduction / synaptic transmission, cholinergic

Components

acetylcholine-gated channel complex / cell junction / intracellular / neuromuscular junction / neuron projection / plasma membrane / postsynaptic membrane

General Function

Acetylcholine-gated cation channel activity

Specific Function

Acetylcholine receptor.

Pfam Domain Function

• Neur_chan_LBD (PF02931)
• Neur_chan_memb (PF02932)

Transmembrane Regions

264-284 293-313 326-346 471-491

Cellular Location

Cell junction

Gene sequence

>lcl|BSEQ0013367|Acetylcholine receptor subunit alpha-type unc-63 (unc-63)
ATGGGACCAAATGACCACGGTTTTGCGTACATCCTCATATTTCTGCTCCTCTCTCCACCA
ACACATGCGAACAGAGATGCGAATCGGTTATTTGAGGATCTTATCGCAGATTACAATAAA
CTGGTGCGACCGGTCAGTGAAAACGGAGAGACACTCGTGGTGACGTTCAAATTAAAATTA
AGTCAATTATTAGATGTTCATGAAAAGAATCAGATTATGACAACAAATGTCTGGTTACAA
CATAGCTGGATGGACTACAAACTTCGATGGGATCCAGTAGAATATGGTGGTGTAGAAGTA
CTGTATGTTCCATCAGATACCATTTGGCTACCTGACGTTGTTTTATATAATAATGCCGAT
GGAAATTATCAAGTTACAATTATGACAAAAGCAAAGCTGACATATAATGGAACAGTTGAA
TGGGCACCGCCTGCGATCTATAAAAGCATGTGCCAAATCGACGTTGAATTCTTTCCATTT
GACCGTCAACAATGTGAAATGAAATTTGGATCATGGACATATGGAGGATTAGAAGTTGAT
CTACAACATAGAGACAAACATTTGGAAAAAGAAATTGAAGAAGACGTTGAAGGTGTTGAT
GGCCCAACAAAAGAAATTGTATGGGTTGTTGATAGAGGAATTGATTTAAGTGATTATTAT
CCATCTGTCGAATGGGATATTTTAAATGTTCCCGGAAAAAGGCATTCCAAGCGATACCCA
TGTTGCGAAAGTCCATTCATAGACATCACATACGAGATTCATCTTCGAAGGAAAACGTTA
TTCTACACAGTAAATCTAATATTCCCTTCAGTTGGAATCAGTTTTCTCACGGCACTTGTA
TTCTATCTACCATCGGATGGAGGTGAAAAAATCTCACTTTGTATTTCGATTCTTATCTCG
TTGACTGTTTTCTTCCTTCTGCTCGTAGAGATTATTCCATCAACATCACTTGTGATTCCA
TTAATTGGAAAATATCTTCTATTTACAATGGTTCTTGTCACATTATCTGTGGTGGTTACT
GTAGTTACATTGAATGTACATTATCGATCCCCAACAACACATACAATGCCAAAATGGATG
AAGCGGTTATTCGTGGATTTTCTGCCAAAATATCTTCTCATGACACGACCGCAACCTCCT
GGTCATCATAGCAAACCAAATCGGAAGTTCGACTCCCGTGCATCAACATTCAGTATTGGA
GTGAATCATGTATTGGGACAGAATTCTGAATTATTATCACCAGGACTCAATTCCAATAGG
GAAGAGTCTTCATTTACTTTACCACGCGACAACTCGCCAGTTCGATCTGCTGTCGAAAGT
GTTGCCTATATAGCGGATCATTTGAAAAACGAGGAAGATGATAAACAGGTAATCGAGGAC
TGGAAATACATATCAGTCGTCATGGATCGAATATTTTTAATCACATTCACTTTTGCTTGT
GCTTTTGGAACCGTTGTGATTATTGCACGTGCACCGTCCATTTACGATAACACGCCGGCT
CTTGCTTAG

Chromosome Location

Not Available

Locus

Not Available

External Identifiers

Resource	Link
UniProtKB ID	Q9N587
UniProtKB Entry Name	ACH6_CAEEL

General References

1. Culetto E, Baylis HA, Richmond JE, Jones AK, Fleming JT, Squire MD, Lewis JA, Sattelle DB: The Caenorhabditis elegans unc-63 gene encodes a levamisole-sensitive nicotinic acetylcholine receptor alpha subunit. J Biol Chem. 2004 Oct 8;279(41):42476-83. Epub 2004 Jul 27. [Article]
2. Authors unspecified: Genome sequence of the nematode C. elegans: a platform for investigating biology. Science. 1998 Dec 11;282(5396):2012-8. [Article]
3. Kaji H, Kamiie J, Kawakami H, Kido K, Yamauchi Y, Shinkawa T, Taoka M, Takahashi N, Isobe T: Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis elegans and suggests an atypical translocation mechanism for integral membrane proteins. Mol Cell Proteomics. 2007 Dec;6(12):2100-9. Epub 2007 Aug 30. [Article]

Drug Relations

Drug Relations

DrugBank ID	Name	Drug group	Pharmacological action?	Actions	Details
DB00848	Levamisole	approved, investigational, vet_approved, withdrawn	unknown	activator	Details