Retinol dehydrogenase 8
Details
- Name
- Retinol dehydrogenase 8
- Synonyms
- 1.1.1.300
- Photoreceptor outer segment all-trans retinol dehydrogenase
- PRRDH
- SDR28C2
- Short chain dehydrogenase/reductase family 28C member 2
- Gene Name
- RDH8
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0004562|Retinol dehydrogenase 8 MAAAPRTVLISGCSSGIGLELAVQLAHDPKKRYQVVATMRDLGKKETLEAAAGEALGQTL TVAQLDVCSDESVAQCLSCIQGEVDVLVNNAGMGLVGPLEGLSLAAMQNVFDTNFFGAVR LVKAVLPGMKRRRQGHIVVISSVMGLQGVIFNDVYAASKFALEGFFESLAIQLLQFNIFI SLVEPGPVVTEFEGKLLAQVSMAEFPGTDPETLHYFRDLYLPASRKLFCSVGQNPQDVVQ AIVNVISSTRPPLRRQTNIRYSPLTTLKTVDSSGSLYVRTTHRLLFRCPRLLNLGLQCLS CGCLPTRVRPR
- Number of residues
- 311
- Molecular Weight
- 33755.02
- Theoretical pI
- 8.48
- GO Classification
- Functionsestradiol 17-beta-dehydrogenase activity / NADP-retinol dehydrogenase activity / retinol dehydrogenase activityProcessesestrogen biosynthetic process / phototransduction, visible light / retinoid metabolic process / steroid biosynthetic process / visual perceptionComponentscytoplasm / integral component of plasma membrane
- General Function
- Retinol dehydrogenase activity
- Specific Function
- Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinal to all-trans-retinol. May play a role in the regeneration of visual pigment at high light intensity (By similarity).
- Pfam Domain Function
- adh_short (PF00106)
- Transmembrane Regions
- 86-106 137-157 169-189
- Cellular Location
- Membrane
- Gene sequence
>lcl|BSEQ0019270|Retinol dehydrogenase 8 (RDH8) ATGAATGGTCAGAGTCAGGTGCTGCCCGGCGGAGGTCACGAGTCCAGGGAGGGGATCAAC ATGGCCGCTGCACCCCGGACTGTGTTGATCTCCGGCTGCTCATCAGGAATTGGTCTGGAA CTTGCAGTGCAACTGGCCCATGACCCCAAGAAGCGCTACCAGGTCGTGGCCACCATGAGG GACCTGGGGAAGAAGGAGACACTGGAGGCAGCTGCTGGGGAGGCTCTGGGGCAGACCCTC ACCGTGGCCCAGCTGGACGTGTGCAGTGATGAGTCGGTGGCCCAGTGTCTCAGCTGTATC CAGGGAGAAGTGGACGTGCTGGTGAATAATGCTGGAATGGGCCTGGTGGGGCCCCTGGAG GGGCTCAGCCTTGCTGCCATGCAGAATGTCTTTGACACCAACTTTTTCGGAGCTGTCCGT CTCGTCAAAGCTGTGCTTCCAGGCATGAAGAGGAGGCGGCAGGGCCACATCGTGGTGATC AGCAGTGTCATGGGCCTGCAGGGTGTCATCTTCAACGATGTCTATGCAGCTTCCAAGTTC GCCCTGGAGGGATTCTTCGAAAGCCTCGCTATCCAGCTGCTGCAGTTCAACATCTTCATC TCCCTGGTGGAGCCAGGCCCCGTGGTCACCGAGTTTGAGGGGAAGCTTCTGGCGCAGGTT TCTATGGCTGAGTTCCCAGGCACTGACCCTGAGACCCTGCACTACTTCCGGGACCTCTAT CTCCCAGCCTCCAGGAAGCTGTTTTGCTCCGTGGGACAGAACCCACAGGACGTGGTTCAG GCCATTGTCAACGTCATCAGCTCGACTCGACCACCCCTGCGCCGACAGACCAACATCCGC TACTCGCCGCTGACCACGCTCAAAACCGTGGATTCCTCTGGCAGCCTGTATGTGCGAACG ACCCACCGCCTCCTCTTCCGCTGTCCACGCCTCCTCAACCTTGGCCTTCAATGTCTGTCC TGCGGCTGCCTCCCAACGCGGGTGCGGCCAAGATGA
- Chromosome Location
- 19
- Locus
- 19p13.2-p13.3
- External Identifiers
Resource Link UniProtKB ID Q9NYR8 UniProtKB Entry Name RDH8_HUMAN GenBank Protein ID 7527474 GenBank Gene ID AF229845 GenAtlas ID RDH8 HGNC ID HGNC:14423 - General References
- Rattner A, Smallwood PM, Nathans J: Identification and characterization of all-trans-retinol dehydrogenase from photoreceptor outer segments, the visual cycle enzyme that reduces all-trans-retinal to all-trans-retinol. J Biol Chem. 2000 Apr 14;275(15):11034-43. [Article]
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