Amiloride-sensitive amine oxidase [copper-containing]
Details
- Name
- Amiloride-sensitive amine oxidase [copper-containing]
- Synonyms
- 1.4.3.22
- ABP1
- Amiloride-binding protein 1
- Amine oxidase copper domain-containing protein 1
- DAO
- Histaminase
- Gene Name
- AOC1
- Organism
- Pig
- Amino acid sequence
>lcl|BSEQ0013249|Amiloride-sensitive amine oxidase [copper-containing] MGRGTLALGWAGAALLLLQMLAAAERSPRTPGGKAGVFADLSAQELKAVHSFLWSQKELK LEPSGTLTMAKNSVFLIEMLLPKKQHVLKFLDKGHRRPVREARAVIFFGAQEQPNVTEFA VGPLPTPRYMRDLPPRPGHQVSWASRPISKAEYALLSHKLQEATQPLRQFFRRTTGSSFG DCHEQCLTFTDVAPRGLASGQRRTWFILQRQMPGYFLHPTGLELLVDHGSTNAQDWTVEQ VWYNGKFYRSPEELAQKYNDGEVDVVILEDPLAKGKDGESLPEPALFSFYQPRGDFAVTM HGPHVVQPQGPRYSLEGNRVMYGGWSFAFRLRSSSGLQILDVHFGGERIAYEVSVQEAVA LYGGHTPAGMQTKYIDVGWGLGSVTHELAPDIDCPETATFLDALHHYDADGPVLYPRALC LFEMPTGVPLRRHFNSNFSGGFNFYAGLKGQVLVLRTTSTVYNYDYIWDFIFYPNGVMEA KMHATGYVHATFYTPEGLRYGTRLHTHLIGNMHTHLVNYRVDLDVAGTTNSFQTLQMELE NITNPWSPRHRLVQPTLKQTRYSRERQAAFRFGQPLPKYLLITSPKENPWGHTRSYRLQL HSMADQVLPPGWQEERAVTWARYPLAVTRYRESELSSSSIYNQNDPWDPPVVFEEFLRNN ENIEDEDLVAWVTVGFLHIPHSEDIPNTATPGNSVGFLLRPFNFFPEDPALASRDLVVVW PLENGSTYAQRWIPEEDQSCLKPPPFSYNGSYRPV
- Number of residues
- 755
- Molecular Weight
- 85474.24
- Theoretical pI
- Not Available
- GO Classification
- Functionscopper ion binding / diamine oxidase activity / drug binding / heparin binding / histamine oxidase activity / methylputrescine oxidase activity / primary amine oxidase activity / propane-1,3-diamine oxidase activity / protein complex binding / quinone binding / receptor activity / zinc ion bindingProcessesamine metabolic process / cellular response to azide / cellular response to copper ion / cellular response to copper ion starvation / cellular response to histamine / oxidation-reduction process / response to antibiotic / response to drugComponentsbicellular tight junction / extracellular space / plasma membrane
- General Function
- Zinc ion binding
- Specific Function
- Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Gene sequence
>lcl|BSEQ0013250|Amiloride-sensitive amine oxidase [copper-containing] (AOC1) ATGGGGCGGGGGACCCTGGCCCTCGGCTGGGCCGGCGCTGCTCTCCTGCTGCTGCAGATG TTGGCCGCAGCGGAGCGCTCCCCACGGACCCCAGGCGGCAAGGCCGGGGTGTTTGCGGAC CTGAGCGCTCAAGAGCTGAAGGCCGTGCACAGCTTCCTCTGGTCCCAGAAGGAGCTGAAG CTGGAGCCGTCGGGAACACTGACCATGGCCAAGAACTCCGTATTCCTCATTGAGATGCTG CTCCCCAAGAAGCAGCACGTGCTGAAATTTCTGGATAAAGGCCACAGGCGTCCCGTGCGG GAAGCTCGGGCCGTCATCTTCTTCGGAGCCCAGGAGCAGCCCAACGTCACCGAGTTTGCG GTGGGGCCGCTGCCAACGCCCCGTTACATGCGAGACCTGCCCCCGAGGCCGGGGCACCAG GTCTCCTGGGCCTCCAGGCCCATCTCTAAGGCAGAGTATGCCCTCCTGAGCCACAAGCTG CAGGAGGCCACCCAACCCCTGCGCCAGTTTTTCCGTCGCACCACGGGCTCCTCCTTCGGA GACTGCCACGAGCAGTGCCTGACCTTCACCGACGTGGCGCCCCGCGGCTTGGCCTCTGGC CAGCGCCGCACCTGGTTCATCTTGCAGCGCCAAATGCCAGGCTACTTCTTGCACCCCACG GGGCTGGAACTCCTGGTGGATCATGGAAGCACGAACGCCCAAGACTGGACGGTGGAGCAG GTCTGGTACAACGGGAAATTCTACCGCAGCCCCGAAGAGCTGGCACAGAAGTATAACGAT GGAGAGGTGGATGTGGTGATCCTGGAGGACCCCCTTGCCAAGGGCAAGGATGGAGAGAGC CTGCCAGAGCCAGCCCTCTTCTCTTTCTACCAGCCACGTGGGGACTTTGCCGTCACCATG CACGGCCCCCACGTGGTCCAGCCCCAGGGCCCCCGCTACAGCCTGGAGGGCAACAGGGTG ATGTATGGGGGCTGGAGCTTCGCCTTTCGCCTGCGCTCCTCCTCCGGGCTGCAGATCCTG GACGTGCACTTCGGAGGTGAGCGCATAGCCTACGAGGTGAGCGTGCAGGAGGCCGTGGCG CTGTACGGAGGGCACACCCCTGCAGGCATGCAGACCAAGTACATAGACGTGGGCTGGGGC CTGGGCAGCGTCACGCATGAGCTGGCCCCTGACATCGACTGCCCAGAGACAGCCACCTTC CTAGACGCCCTCCATCACTACGACGCAGACGGCCCCGTCCTCTACCCCCGGGCCCTCTGT CTCTTCGAGATGCCCACGGGGGTGCCCCTCCGGCGGCACTTCAACTCCAATTTTAGCGGC GGCTTCAATTTCTACGCGGGGCTCAAGGGCCAGGTGTTGGTGCTGCGGACAACGTCGACG GTCTACAATTATGACTACATCTGGGACTTCATCTTCTACCCCAACGGGGTGATGGAGGCG AAGATGCACGCCACTGGCTACGTCCACGCCACCTTCTACACCCCTGAGGGCCTGCGCTAT GGGACACGCCTGCACACACACTTGATCGGCAACATGCACACGCACCTGGTGAATTACCGC GTCGACCTGGACGTGGCAGGCACCACAAATAGCTTCCAGACCCTGCAGATGGAGCTAGAA AACATCACCAACCCCTGGAGCCCGAGACACCGCCTGGTGCAGCCCACACTCAAGCAGACC AGGTACTCCCGCGAGCGCCAGGCGGCCTTCCGCTTCGGACAGCCTCTGCCCAAGTACCTG CTCATTACCAGCCCCAAGGAGAACCCGTGGGGCCACACGCGCAGCTACCGCCTGCAGCTC CACTCCATGGCCGACCAAGTGCTGCCCCCAGGCTGGCAGGAGGAGCGGGCTGTCACCTGG GCCAGGTACCCCCTGGCCGTGACCAGATACCGGGAATCTGAGCTCTCCAGCAGCAGCATC TACAACCAGAACGACCCCTGGGACCCACCCGTGGTCTTTGAGGAGTTTCTTCGAAACAAT GAAAACATTGAAGATGAGGACCTGGTGGCCTGGGTCACAGTGGGCTTCCTGCACATCCCC CACTCAGAAGACATCCCCAACACGGCCACACCCGGGAACTCTGTGGGCTTCCTGCTCCGG CCCTTCAACTTCTTTCCAGAGGACCCAGCCCTGGCGTCCAGAGACCTCGTGGTCGTGTGG CCTCTGGAAAATGGCTCCACCTACGCCCAGCGCTGGATCCCCGAGGAGGACCAGAGCTGC CTGAAGCCGCCCCCTTTTAGCTACAATGGATCCTACAGGCCTGTGTGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q9TRC7 UniProtKB Entry Name AOC1_PIG - General References
- Novotny WF, Chassande O, Baker M, Lazdunski M, Barbry P: Diamine oxidase is the amiloride-binding protein and is inhibited by amiloride analogues. J Biol Chem. 1994 Apr 1;269(13):9921-5. [Article]
- Janes SM, Palcic MM, Scaman CH, Smith AJ, Brown DE, Dooley DM, Mure M, Klinman JP: Identification of topaquinone and its consensus sequence in copper amine oxidases. Biochemistry. 1992 Dec 8;31(48):12147-54. [Article]
- Wintero AK, Fredholm M, Davies W: Evaluation and characterization of a porcine small intestine cDNA library: analysis of 839 clones. Mamm Genome. 1996 Jul;7(7):509-17. [Article]
- Huang Y, Mechref Y, Novotny MV: N-linked oligosaccharide structures in the diamine oxidase from porcine kidney. Carbohydr Res. 2000 Jan 12;323(1-4):111-25. [Article]